Zobrazeno 1 - 10
of 22
pro vyhledávání: ''
Autor:
Yu, Jia, Shi, Yue, Zhao, Kaixuan, Yang, Guang, Yu, Lina, Li, Yuxin, Andersson, Eva-Marie, Ämmälä, Carina, Yang, Shao-Nian, Berggren, Per-Olof
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We reveal that increased expression of CaV3.1 channels in rat islets selectively impairs first-phase glucose-stimulated insulin secretion. This deterioration is recapitulated in human islets. Its causal role in diabetes development is cl
Autor:
Jenna M. Antonucci, Zhihua Qin, Li Wu, Olga Buzovetsky, Yong Xiong, Denis C. Guttridge, Mario L. Santiago, Katherine J. Ladner, Bradley S. Barrett, Jacob S. Yount, Corine St. Gelais, Karthik M. Kodigepalli, Kirsten M. Knecht, Serena Bonifati, Shuliang Chen, Sun Hee Kim
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(16)
Sterile alpha motif and HD-domain-containing protein 1 (SAMHD1) blocks replication of retroviruses and certain DNA viruses by reducing the intracellular dNTP pool. SAMHD1 has been suggested to down-regulate IFN and inflammatory responses to viral inf
Autor:
Shivakumar Vasanth, Jonathan M. Shillingford, Nicholas Doerr, Thomas Weimbs, Terry Watnick, Mike T. Kinter, Jeffrey J. Talbot, Sambuddho Mukherjee
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(19)
Mutations in polycystin-1 (PC1) lead to autosomal-dominant polycystic kidney disease (ADPKD), a leading cause of renal failure for which no treatment is available. PC1 is an integral membrane protein, which has been implicated in the regulation of mu
Autor:
Adam G. Blaszczak, Barbara J. Graves, Hyun Seo Kang, Gregory M. Lee, Mary L. Nelson, Lawrence P. McIntosh, Desmond K. W. Lau
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(22)
Ras/MAPK signaling is often aberrantly activated in human cancers. The downstream effectors are transcription factors, including those encoded by the ETS gene family. Using cell-based assays and biophysical measurements, we have determined the mechan
Autor:
Shaun G. Weller, Hong Cao, Mirco Capitani, Mark A. McNiven, Alberto Luini, Massimo Micaroni, Michele Sallese
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 107 (2010): 5863–5868. doi:10.1073/pnas.0915123107
info:cnr-pdr/source/autori:Weller S.G.; Capitani M.; Cao H.; Micaroni M.; Luini A.; Sallese M.; McNiven M.A./titolo:Src kinase regulates the integrity and function of the Golgi apparatus via activation of dynamin 2/doi:10.1073%2Fpnas.0915123107/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2010/pagina_da:5863/pagina_a:5868/intervallo_pagine:5863–5868/volume:107
info:cnr-pdr/source/autori:Weller S.G.; Capitani M.; Cao H.; Micaroni M.; Luini A.; Sallese M.; McNiven M.A./titolo:Src kinase regulates the integrity and function of the Golgi apparatus via activation of dynamin 2/doi:10.1073%2Fpnas.0915123107/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2010/pagina_da:5863/pagina_a:5868/intervallo_pagine:5863–5868/volume:107
The size and integrity of the Golgi apparatus is maintained via a tightly controlled regulation of membrane traffic using a variety of different signaling and cytoskeletal proteins. We have recently observed that activation of c-Src has profound effe
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(34)
Cancer cells often display defects in mitochondrial respiration, thus the identification of pathways that promote cell survival under this metabolic state may have therapeutic implications. Here, we report that the targeted ablation of mitochondrial
Autor:
Nenad Tomasevic, Woodrow E. Lomas, Arie Abo, Sophie A. Hazell, Sejal M. Patel, Mei Zhou, Michael D. Levy, John Leung, Melissa Dixon, Marie Wagle, Wen Sheng Nie, Walter D. Funk, Jason Williams, Karolyn Tran, Jessica M. Bright, Kyung Ah Kim, Minke E. Binnerts, Yi Liu, Xiaoming Zhan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 104(37)
The R-Spondin (RSpo) family of secreted proteins act as potent activators of the Wnt/β-catenin signaling pathway. We have previously shown that RSpo proteins can induce proliferative effects on the gastrointestinal epithelium in mice. Here we provid
Autor:
Ming-Tao Wu, Dianqing Wu, Teresa Sanchez, Christopher D. Kontos, Timothy Hla, Shobha Thangada, Hong Wu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 102(12)
PTEN, a tumor suppressor phosphatase, is important in the regulation of cell migration and invasion. Physiological regulation of PTEN (phosphatase and tensin homolog deleted on chromosome 10) by cell surface receptors has not been described. Here, we
Autor:
Frank Eisenhaber, Lukas A. Huber, Tim Clausen, Hans D. Bartunik, Mariana E. G. de Araujo, Sebastian Maurer-Stroh, Robert Kurzbauer, David Teis, Mirko Hekman, Ulf R. Rapp, Gleb Bourenkov
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 101(30)
Signaling pathways in eukaryotic cells are often controlled by the formation of specific signaling complexes, which are coordinated by scaffold and adaptor proteins. Elucidating their molecular architecture is essential to understand the spatial and
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 101(23)
Aurora-A kinase is necessary for centrosome maturation, for assembly and maintenance of a bipolar spindle, and for proper chromosome segregation during cell division. Aurora-A is an oncogene that is overexpressed in multiple human cancers. Regulation