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Autor:
Eamonn Sheridan, Ellanor L. Whiteley, Tarek Z. Deeb, Roland Bürli, Nicholas J. Brandon, Gonzalo S. Tejeda, George S. Baillie, Stephen J. Moss
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Phosphodiesterase 10A (PDE10A) is as a target of interest in Huntington’s disease (HD) as levels of the enzyme have been shown to decrease prior to the development of the hallmark motor symptoms. Clearly, a better understanding of how
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(41)
ZFAND5/ZNF216, a member of the zinc finger AN1-type domain family, is abundant in heart and brain, but is induced in skeletal muscle during atrophy (although not in proteotoxic stress). Because mice lacking ZFAND5 exhibit decreased atrophy, a role in
Autor:
Jenna M. Antonucci, Zhihua Qin, Li Wu, Olga Buzovetsky, Yong Xiong, Denis C. Guttridge, Mario L. Santiago, Katherine J. Ladner, Bradley S. Barrett, Jacob S. Yount, Corine St. Gelais, Karthik M. Kodigepalli, Kirsten M. Knecht, Serena Bonifati, Shuliang Chen, Sun Hee Kim
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(16)
Sterile alpha motif and HD-domain-containing protein 1 (SAMHD1) blocks replication of retroviruses and certain DNA viruses by reducing the intracellular dNTP pool. SAMHD1 has been suggested to down-regulate IFN and inflammatory responses to viral inf
Autor:
Shakiba P. Baniasadi, Zhenyue Hao, Yi Sheng, Jillian Haight, Lisa Jones, Kelsie L. Thu, Carmen Dominguez-Brauer, Rahima Khatun, Andrew J. Elia, Tak W. Mak, Parameswaran Ramachandran
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(7)
Wnt signaling, named after the secreted proteins that bind to cell surface receptors to activate the pathway, plays critical roles both in embryonic development and the maintenance of homeostasis in many adult tissues. Two particularly important cell
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(8)
In mammalian reproduction, implantation is one of the most critical events. Failure of implantation and the subsequent decidualization contribute to more than 75% of pregnancy losses in women. Our laboratory has previously reported that inhibition of
Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(37)
Hereditary spastic paraplegias are inherited neurological disorders characterized by progressive lower-limb spasticity and weakness. Although more than 50 genetic loci are known [spastic gait (SPG)1 to -57], over half of hereditary spastic paraplegia
HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(6)
HSVs transit from vigorous replication at the portal of entry into the body to a latent state in sensory neurons in which only noncoding (e.g., latency-associated transcript) and micro-RNAs are expressed. In productive infection, viral genes must be
Autor:
Joachim W. Deitmer, William S. Sly, Alena Spiess, Abdul Waheed, Hans-Peter Schneider, Holger M. Becker, Michael Klier, Fabian T. Andes, Marco D. Alt
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(4)
Soluble cytosolic carbonic anhydrases (CAs) are well known to participate in pH regulation of the cytoplasm of mammalian cells. Membrane-bound CA isoforms—such as isoforms IV, IX, XII, XIV, and XV—also catalyze the reversible conversion of carbon
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(41)
Ookinete invasion of the mosquito midgut is an essential step for the development of the malaria parasite in the mosquito. Invasion involves recognition between a presumed mosquito midgut receptor and an ookinete ligand. Here, we show that enolase li
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(31)
GPR56, an orphan G protein-coupled receptor (GPCR) from the family of adhesion GPCRs, plays an indispensable role in cortical development and lamination. Mutations in the GPR56 gene cause a malformed cerebral cortex in both humans and mice that resem