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Autor:
Patricia L. Opresko, Simon C. Watkins, Namrata Kumar, Dmytro Kolodieznyi, Vera Roginskaya, Marcel P. Bruchez, Elise Fouquerel, Bennett Van Houten, Wei Qian, Sruti Shiva
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance It is highly controversial whether secondary reactive oxygen species generated by dysfunctional mitochondria are able to diffuse across the cytoplasm to the nucleus and cause subsequent nuclear changes. We have developed a targeted chemo
Autor:
Bohumil Fafilek, Peter Konik, Iva Gudernova, Jennifer Zieba, Miroslav Varecha, Sara P. Abraham, Tomas Gregor, Ivan Duran, David Šmajs, Gert Jansen, Marketa Tomanova, Pavel Krejci, So Hyun Park, Jieun Song, Tomáš Bárta, Deborah Krakow, Lukas Balek, Alexandru Nita, David Potesil, Zheng Fu, Neha Basheer, Hyuk Wan Ko, Aleš Hampl, Michaela Bosakova, Jana Kučerová, Juraj Bosák, Lukáš Trantírek, Zbynek Zdrahal
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the U.S.A., 116(10), 4316-4325. National Academy of Sciences
Proceedings of the National Academy of Sciences of the U.S.A., 116(10), 4316-4325. National Academy of Sciences
Significance A properly functioning primary cilium is prerequisite for both normal development and aging of all ciliated organisms, including humans. In vertebrates, the signaling of Hedgehog family morphogens depends entirely on primary cilium. Rece
Autor:
Shin-ichiro Yoshimura, Mitsunori Fukuda, Tomoya Eguchi, Tetta Fujimoto, Masato Koike, Tadayuki Komori, Akihiro Harada, Maria Sakurai, Takeshi Iwatsubo, Tomoki Kuwahara, Genta Ito
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance LRRK2, a protein kinase related to Parkinson’s disease, is implicated in the maintenance of lysosomes, and a subset of Rab GTPases has been identified as bona fide substrates of LRRK2. Here, we reveal a key stress-responsive pathway co
Autor:
Aparna Renigunta, Nina Himmerkus, Markus Bleich, Mingzhu Nie, Jianghui Hou, Matthias T.F. Wolf, Abby Sunq, Vijay Renigunta, Catarina Quintanova
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(38)
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) was previously considered to be a paracellular channelopathy caused by mutations in the claudin-16 and claudin-19 genes. Here, we provide evidence that a missense FHHNC mutation
Autor:
Deepthi Menon, George A. Timmons, Sarah S. Geiger, Eva M. Palsson-McDermott, Daniel J. O’Connell, Anne M. Curtis, Stefano Angiari, Richard G. Carroll, Dylan G. Ryan, Zbigniew Zaslona, Darren J. Fitzpatrick, James O. Early, Karsten Hokamp, Sarah E. Corcoran, Ramnik J. Xavier, Cathy A. Wyse, Mariana P. Cervantes-Silva, Luke A. J. O'Neill
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The molecular clock provides an anticipatory mechanism, allowing organisms to prepare and respond to daily changes in the external environment. The response of the innate immune system to pathogenic threats is dependent on time of day; h
Autor:
Soo Hyun Eom, Shinhye Park, Myung Hee Kim, Yumi Kwon, Eun-Young Lee, Jae-Kyung Hyun, Jungwon Hwang, Sanghyeon Choi, Youngjin Lee, Byoung Sik Kim, Cheolju Lee, Jihyun F. Kim
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance MARTX toxins present across multiple bacterial genera are primary virulence factors that facilitate initial colonization, dissemination, and lethality in a wide range of hosts, including humans. Upon entry into host cells, the toxins und
Autor:
Tian-Xia Jiang, Luming Zhou, Yousheng Shu, Qian-Qian Zhu, Jiang-Bo Zou, Wensheng Zhang, Li Yu, Ting-Ting Du, Ze'ev Ronai, Alfred L. Goldberg, Shuichi Matsuzawa, Cui Hua Liu, Fang Guo, Wang Guangfei, Juan-Juan Liu, Zi-Yu Luo, Xiao-Bo Qiu, Peng Li
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(27)
BRUCE/Apollon is a membrane-associated inhibitor of apoptosis protein that is essential for viability and has ubiquitin-conjugating activity. On initiation of apoptosis, the ubiquitin ligase Nrdp1/RNF41 promotes proteasomal degradation of BRUCE. Here
Autor:
Sandra Schamus-Haynes, Moiseeva Tn, Hatice U. Osmanbeyoglu, Simon C. Watkins, Chenao Qian, Christopher J. Bakkenist, Norie Sugitani, Yandong Yin, Michael J. Calderon, Eli Rothenberg
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The 50,000 origins that replicate the human genome are selected from an excess of licensed origins. Firing licensed origins that would otherwise be passively replicated is a simple mechanism to recover DNA replication between stalled rep
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(23)
Opsins form a family of light-activated, retinal-dependent, G protein-coupled receptors (GPCRs) that serve a multitude of visual and nonvisual functions. Opsin 3 (OPN3 or encephalopsin), initially identified in the brain, remains one of the few membe
Autor:
Chintan K. Kikani, Seong A. Kang, Xiaoying Wu, Sarah Fogarty, Jared Rutter, Steven P. Gygi, David M. Sabatini, Noah Dephoure
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(21)
During skeletal muscle regeneration, muscle stem cells (MuSCs) respond to multiple signaling inputs that converge onto mammalian target of rapamycin complex 1 (mTORC1) signaling pathways. mTOR function is essential for establishment of the differenti