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Autor:
Kazuya Shimura, Masayuki Amano, Hirotomo Nakata, Jun-ichirou Yasunaga, Guangyong Ma, Xiaorui Zuo, Benquan Liu, Masao Matsuoka, Keiko Takemoto, Miho Watanabe
Publikováno v:
Proc Natl Acad Sci U S A
Human retroviruses, including human T cell leukemia virus type 1 (HTLV-1) and HIV type 1 (HIV-1), encode an antisense gene in the negative strand of the provirus. Besides coding for proteins, the messenger RNAs (mRNAs) of retroviral antisense genes h
Autor:
Andrew Sproul, Amanda M. Snead, Raphael Lis, Tyler M. Lu, Andrew P. Minotti, Dritan Agalliu, David Redmond, Lorenz Studer, Shahin Rafii, Howard A. Fine, Sean Houghton, José Gabriel Barcia Durán, Zev Rosenwaks, Tarig Magdeldin, Duc-Huy T. Nguyen, Jenny Xiang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Human PSC-derived iBMECs have been generated to study disease mechanisms and drug development for neurological disorders. However, their full transcriptomic characterization is unclear, which could result in inaccurate physiological stud
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(38)
Human cytomegalovirus (HCMV) manipulates many aspects of host cell biology to create an intracellular milieu optimally supportive of its replication and spread. Our study reveals that levels of several components of the purinergic signaling system, i
Autor:
Anna Luganini, Giorgio Gribaudo, Luca Munaron, Alessandra Fiorio Pla, Giovanna Di Nardo, Gianfranco Gilardi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(52)
The human cytomegalovirus (HCMV) US12 gene family comprises a set of 10 contiguous genes (US12 to US21) with emerging roles in the regulation of virus cell tropism, virion composition, and immunoevasion. Of all of the US12 gene products, pUS21 shows
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(44)
Substrate rigidity affects many physiological processes through mechanochemical signals from focal adhesion (FA) complexes that subsequently modulate gene expression. We find that shuttling of the LIM domain (domain discovered in the proteins, Lin11,
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(41)
Axon injury in response to trauma or disease stimulates a self-destruction program that promotes the localized clearance of damaged axon segments. Sterile alpha and Toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) is an evolutionari
Autor:
Feng-Ming Lin, Yong Zuo, Long Sheng Lu, Tasneem Bawa-Khalfe, Edward T.H. Yeh, Chao Huang, Ruhee Dere
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(43)
Two Sentrin/small ubiquitin-like modifier (SUMO)-specific protease 7 (SENP7) variants are naturally expressed in breast epithelia. Breast cancer (BCa) onset down-regulates the short SENP7 splice variant (SENP7S) and enhances the long transcript (SENP
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(22)
During immune-mediated death, death-inducing granzyme (Gzm) proteases concentrate in the nucleus of cells targeted for immune elimination, suggesting that nuclear processes are important targets. Here we used differential 2D proteomics of GzmA-treate
Autor:
Paul Shore, Dean A. Jackson, Daniel Mendoza-Villanueva, Jen Yang Tang, Apolinar Maya-Mendoza, Cesar Lopez-Camacho, Wensheng Deng
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(5)
Filamin A (FLNA) is an actin-binding protein with a well-established role in the cytoskeleton, where it determines cell shape and locomotion by cross-linking actin filaments. Mutations in FLNA are associated with a wide range of genetic disorders. He
Autor:
Peter W. Andrews, Bernat Soria, Daniela Piazzolla, José M. Mato, Raed Abu Dawud, Angelica Horrillo, Daniel Herranz, Pilar López-Nieva, Vincenzo Calvanese, Beatriz Suarez-Alvarez, Nieves Embade, María L. Martínez-Chantar, Manuel Serrano, Manel Esteller, Mercedes Vazquez-Chantada, Mario F. Fraga, Carlos López-Larrea, Abdelkrim Hmadcha, Ester Lara
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Digital.CSIC. Repositorio Institucional del CSIC
Universidad de Barcelona
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Digital.CSIC. Repositorio Institucional del CSIC
6 páginas, 6 figuras, 1 tabla.-- et al.
The longevity-promoting NAD+–dependent class III histone deacetylase Sirtuin 1 (SIRT1) is involved in stem cell function by controlling cell fate decision and/or by regulating the p53-dependent expressi
The longevity-promoting NAD+–dependent class III histone deacetylase Sirtuin 1 (SIRT1) is involved in stem cell function by controlling cell fate decision and/or by regulating the p53-dependent expressi