Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Vishwanath R. Lingappa"'
Autor:
Svenja V. Trossbach, Shriya Sahu, Suganya Selvarajah, Andreas Müller-Schiffmann, Ana Raquel Moreira, Vishwanath R. Lingappa, Irina Soloviev, Ingrid Prikulis, Sebastian Hänsch, Carsten Korth, Rita Marreiros, Stefanie Weidtkamp-Peters
Publikováno v:
Proc Natl Acad Sci U S A
Neurodegenerative diseases feature specific misfolded or misassembled proteins associated with neurotoxicity. The precise mechanisms by which protein aggregates first arise in the majority of sporadic cases have remained unclear. Likely, a first crit
Autor:
Troy D. Wood, Robert Bowser, Arie Gruzman, Evgenia Alpert, Jeffery D. Rothstein, Robert G. Miller, Jian Liu, M. Dharma Prasad, Vishwanath R. Lingappa, Don W. Cleveland, William L. Wood, Ronald L. Hamilton
Publikováno v:
Proceedings of the National Academy of Sciences. 104:12524-12529
Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron degenerative disease whose etiology and pathogenesis remain poorly understood. Most cases of ALS (≈90%) are sporadic (SALS), occurring in the absence of genetic associations. Approxi
Publikováno v:
Proceedings of the National Academy of Sciences. 98:7823-7828
Amino-terminal signal sequences target nascent secretory and membrane proteins to the endoplasmic reticulum for translocation. Subsequent interactions between the signal sequence and components of the translocation machinery at the endoplasmic reticu
Publikováno v:
Proceedings of the National Academy of Sciences. 76:1795-1799
The ability of microsomal membranes to translocate nascent presecretory proteins across their lipid bilayer into the intravesicular space was investigated by using trypsin as a proteolytic probe. We found that under defined conditions trypsin is able
Publikováno v:
Proceedings of the National Academy of Sciences. 75:2338-2342
mRNA from rat mammary glands 13-15 days post partum was translated in a wheat germ cell-free system either in the absence or in the presence of ribosome-denuded membranes prepared from isolated rough microsomes of dog pancreas. Newly synthesized α-l
Publikováno v:
Proceedings of the National Academy of Sciences. 74:2432-2436
Major translation products of bovine pituitary RNA in a wheat germ cell-free system were identified as larger forms (prehormones) of growth hormone and prolactin containing amino-terminal extensions of 26 or 27 and 30 amino acid residues, respectivel