Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Richard H. Gomer"'
Publikováno v:
Proc Natl Acad Sci U S A
Chemotaxis, the guided motion of cells by chemical gradients, plays a crucial role in many biological processes. In the social amoeba Dictyostelium discoideum, chemotaxis is critical for the formation of cell aggregates during starvation. The cells i
Publikováno v:
Proceedings of the National Academy of Sciences. 112:11929-11934
In healing wounds and fibrotic lesions, fibroblasts and monocyte-derived fibroblast-like cells called fibrocytes help to form scar tissue. Although fibrocytes promote collagen production by fibroblasts, little is known about signaling from fibroblast
Publikováno v:
Proceedings of the National Academy of Sciences. 112:8385-8390
Fibrosis is caused by scar tissue formation in internal organs and is associated with 45% of deaths in the United States. Two closely related human serum proteins, serum amyloid P (SAP) and C-reactive protein (CRP), strongly affect fibrosis. In multi
Autor:
Jonathan E. Phillips, Richard H. Gomer
Publikováno v:
Proceedings of the National Academy of Sciences. 109:10990-10995
Chemorepellants may play multiple roles in physiological and pathological processes. However, few endogenous chemorepellants have been identified, and how they function is unclear. We found that the autocrine signal AprA, which is produced by growing
Autor:
John M. Lee, Sandra B. Haudek, Richard H. Gomer, JoAnn Trial, Darrell Pilling, Peter Huebener, Jeffrey R. Crawford, Mark L. Entman, Nikolaos G. Frangogiannis, Ying Xia, Signe Carlson
Publikováno v:
Proceedings of the National Academy of Sciences. 103:18284-18289
We previously described a mouse model of fibrotic ischemia/reperfusion cardiomyopathy (I/RC) arising from daily, brief coronary occlusion. One characteristic of I/RC was the prolonged elevation of monocyte chemoattractant protein 1 (MCP-1), which was
Autor:
Andrew V. Greene, Zachary A. Lewis, Richard H. Gomer, Alejandro Correa, Deborah Bell-Pedersen, Irene J. March
Publikováno v:
Proceedings of the National Academy of Sciences. 100:13597-13602
High-density microarrays were used to profile circadian gene expression in Neurospora crassa cultures grown in constant darkness. We identified 145 clock-controlled genes (ccgs). The ccgs peaked in mRNA accumulation at all phases of the day, with the
Publikováno v:
Proceedings of the National Academy of Sciences. 93:5003-5007
We have developed a mutagenesis technique that uses antisense cDNA to identify genes required for development in Dictyostelium discoideum. We transformed Dictyostelium cells with a cDNA library made from the mRNA of vegetative and developing cells. T
Publikováno v:
Proceedings of the National Academy of Sciences. 83:8624-8628
Extracellular adenosine 3',5'-cyclic monophosphate (cAMP) is required for cell-type-specific gene expression in developing Dictyostelium discoideum. We have developed a microassay for the expression of these genes, using antibodies directed against t
Publikováno v:
Proceedings of the National Academy of Sciences. 78:3531-3535
Exposure of chicken cells grown in tissue culture to heat shock or sodium arsenite results in a dramatic increase in the synthesis of three major polypeptides with molecular weights of 83,000 (HSP 83), 68,000 (HSP 68; referred to here as "thermin"),