Zobrazeno 1 - 3
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pro vyhledávání: '"Jeffrey E. DeClue"'
Publikováno v:
Proceedings of the National Academy of Sciences. 93:9154-9159
The Tsc2 gene, which is mutationally inactivated in the germ line of some families with tuberous sclerosis, encodes a large, membrane-associated GTPase activating protein (GAP) designated tuberin. Studies of the Eker rat model of hereditary cancer st
Publikováno v:
Proceedings of the National Academy of Sciences. 90:5539-5543
The NF1 gene, which is altered in patients with type 1 neurofibromatosis, encodes neurofibromin, a protein whose GTPase-activating function can negatively regulate GTP-Ras by accelerating its conversion to inactive GDP-Ras. In schwannoma cell lines f
Publikováno v:
Proceedings of the National Academy of Sciences. 88:9914-9918
The neurofibromatosis type 1 (NF1) gene responsible for von Recklinghausen neurofibromatosis is related to regulators of ras proteins, and a portion of NF1 that is homologous to the ras GTPase-activating protein (GAP) encodes a similar GTPase-stimula