Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Eric A. Hoffman"'
Autor:
Jennifer S. Gutierrez, Eric P. Hoffman, Yashuo Wang, Xu Liu, Jesse M. Damsker, Eric A. Ortlund, Kanneboyina Nagaraju
Publikováno v:
Proc Natl Acad Sci U S A
Duchenne muscular dystrophy is a genetic disorder that shows chronic and progressive damage to skeletal and cardiac muscle leading to premature death. Antiinflammatory corticosteroids targeting the glucocorticoid receptor (GR) are the current standar
Autor:
Sally K. Nelson, Yetrib Hathout, Bob Mehler, Heather Gordish-Dressman, Linda H. Cripe, Edward N. Brody, Angela Lorts, Malti Nikrad, H. Lee Sweeney, Craig M. McDonald, Robert Kirk DeLisle, Paula R. Clemens, Yvonne M. Kobayashi, Erik K Henricson, Steve C.R. Williams, Pat Furlong, Fintan Steele, Jean K. Mah, Lauren P. Hache, Eric P. Hoffman, Larry Gold, Britta Singer, David Sterling
Publikováno v:
Proceedings of the National Academy of Sciences. 112:7153-7158
Serum biomarkers in Duchenne muscular dystrophy (DMD) may provide deeper insights into disease pathogenesis, suggest new therapeutic approaches, serve as acute read-outs of drug effects, and be useful as surrogate outcome measures to predict later cl
Autor:
Ryan J. Adam, Geoffrey McLennan, Anthony J. Fischer, Michael J. Welsh, Omar A. Itani, Mark J. Hoegger, Alexander J. Tucker, David A. Stoltz, Eman Namati, Maged Awadalla, Eric A. Hoffman
Publikováno v:
Proceedings of the National Academy of Sciences. 111:2355-2360
Mucociliary transport (MCT) is an innate defense mechanism that removes particulates, noxious material, and microorganisms from the lung. Several airway diseases exhibit abnormal MCT, including asthma, chronic bronchitis, and cystic fibrosis. However
Autor:
Sacha Gnjatic, Lloyd J. Old, Erika Ritter, Djordje Atanackovic, Gerd Ritter, Nasser K. Altorki, Eric W. Hoffman, Cathy A. Ferrara, Carsten Bokemeyer, Yanran Cao
Publikováno v:
Proceedings of the National Academy of Sciences. 105:1650-1655
We previously reported results of a phase II trial in which recombinant MAGE-A3 protein was administered with or without adjuvant AS02B to 18 non-small-cell lung cancer (NSCLC) patients after tumor resection. We found that the presence of adjuvant wa
Autor:
Kunle Odunsi, Paulette Mhawech-Fauceglia, Jeannine A. Villella, Chris Andrews, Junko Matsuzaki, Sacha Gnjatic, Bridget Thomas, Gerd Ritter, Shashikant Lele, Eric W. Hoffman, Protul Shrikant, Kerry J. Rodabaugh, Linda Pan, Feng Qian, Lloyd J. Old
Publikováno v:
Proceedings of the National Academy of Sciences. 104:12837-12842
NY-ESO-1 is a “cancer-testis” antigen expressed in epithelial ovarian cancer (EOC) and is among the most immunogenic tumor antigens defined to date. The NY-ESO-1 peptide epitope, ESO 157–170 , is recognized by HLA-DP4-restricted CD4 + T cells a
Autor:
Bridget Chappell, Antony W. Burgess, Anthony T. Papenfuss, Gerd Ritter, Andrew M. Scott, A. M. T. Poon, Wendie Hopkins, Lloyd J. Old, Lawrence M Cher, T. Saunder, Eric W. Hoffman, Fiona E Smyth, Zhanqi Liu, Martin W. Brechbiel, Effie Skrinos, Roger Murphy, Fook-Thean Lee, Carmel Murone, Duncan MacGregor, R. A. Herbertson, Niall C. Tebbutt, Achim A. Jungbluth, S Gill, Terrance Grant Johns
Publikováno v:
Proceedings of the National Academy of Sciences. 104:4071-4076
An array of cell-surface antigens expressed by human cancers have been identified as targets for antibody-based therapies. The great majority of these antibodies do not have specificity for cancer but recognize antigens expressed on a range of normal
Autor:
Dennis Panicali, Armin Bender, Linda Pan, Danila Valmori, Julia Karbach, Lloyd J. Old, Erika Ritter, Sacha Gnjatic, Antje Neumann, Maha Ayyoub, Gerd Ritter, Herbert F. Oettgen, Dirk Jäger, Alexander Knuth, Eric A. Hoffman, Elke Jager
Publikováno v:
Proceedings of the National Academy of Sciences. 103:14453-14458
NY-ESO-1 is a cancer/testis antigen expressed in a range of human malignancies, and a number of vaccine strategies targeting NY-ESO-1 are being developed. In the present study, the safety and immunogenicity of recombinant vaccinia-NY-ESO-1 and recomb
Publikováno v:
Scopus-Elsevier
To gain insight into the normal controls mediating expression of the c-Ki-ras protooncogene, we have identified DNA sequence elements within its promoter that are essential for transcriptional activity. Transient expression assays using the bacterial
Autor:
Darryl W. Maher, Simon Green, Yao-Tseng Chen, Roger Murphy, Sue Sturrock, Tina Luke, Eugene Maraskovsky, Duncan MacGregor, Andrew Cuthbertson, Ian D. Davis, Achim A. Jungbluth, Sacha Gnjatic, Jonathan Cebon, Tsin Yee Tai, Grant A. McArthur, Gerd Ritter, Heather Jackson, Eric W. Hoffman, Andrew M. Scott, Susan V. Mitchell, Lloyd J. Old, Mark Shackleton, Phillip Parente, Weisan Chen, Wendie Hopkins, Nektaria Dimopoulos, Qiyuan Chen, Lena Miloradovic
Publikováno v:
Proceedings of the National Academy of Sciences. 102:9734-9734