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Publikováno v:
Proc Natl Acad Sci U S A
Organelle remodeling is critical for cellular homeostasis, but host factors that control organelle function during microbial infection remain largely uncharacterized. Here, a genome-scale CRISPR/Cas9 screen in intestinal epithelial cells with the pro
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 43
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Light-induced extrasynaptic dopamine release in the retina reduces adenosine 3′, 5′-cyclic monophosphate (cAMP) in rod photoreceptor cells, which is thought to mediate light-dependent desensitization. However, the fine time course of the cAMP dyn
Autor:
Elena Ivanova, Connie H Wong, Bang V. Bui, Gene Venables, Samuel A Mills, Michael A Dixon, Flora Hui, Zheng He, Kirstan A. Vessey, Vickie Hy Wong, Josh Tonc, James C Young, Botir T. Sagdullaev, Andrew I Jobling, Ursula Greferath, Erica L. Fletcher, Joanna A. Phipps
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance This work identifies a role for microglia, the innate immune cells of the CNS, in the local control of the retinal vasculature and identifies deficits early in diabetes. Microglia contact neurons and vasculature and express several vasoa
Autor:
Doron Merkler, Ingrid Wagner, Mario Kreutzfeldt, Karen Cornille, Tobias M. Brunner, Marco Künzli, David Schreiner, Kerstin Narr, Mirela Dimitrova, Yusuf I. Ertuna, Lukas Bestmann, Benedict Fallet, Max Löhning, Carolyn G. King, Tiago Jose Abreu Mota, Anna-Friederike Marx, Florian Geier, Katrin Martin, Daniel D. Pinschewer
Publikováno v:
Proc Natl Acad Sci U S A
Chronic viral infections subvert protective B cell immunity. An early type I interferon (IFN-I)-driven bias to short-lived plasmablast differentiation leads to clonal deletion, so-called "decimation," of antiviral memory B cells. Therefore, prophylac
Autor:
Theresa T. Pizarro, Wendy A. Goodman, Brian Richardson, Mark J. Cameron, Hannah L. Havran, Sarah Bedoyan
Publikováno v:
Proc Natl Acad Sci U S A
Signaling of 17β-estradiol (estrogen) through its two nuclear receptors, α and β (ERα, ERβ), is an important mechanism of transcriptional regulation. Although ERs are broadly expressed by cells of the immune system, the mechanisms by which they
Autor:
Chen Feng Qi, Yu Chih Peng, Yang Cheng, Xiangyu Yao, Sonja M. Best, Xiao He, Timothy G. Myers, Lu Xia, Cui Zhang, Ruili Huang, Wenxiang Sun, Brajesh K. Singh, Rong Fu Wang, Carole A. Long, Keyla C. Tumas, Jian Wu, Silvia Bolland, Channe Gowda, Xin-zhuan Su, Xiao Yu
Publikováno v:
Proc Natl Acad Sci U S A
Malaria infection induces complex and diverse immune responses. To elucidate the mechanisms underlying host–parasite interaction, we performed a genetic screen during early (24 h) Plasmodium yoelii infection in mice and identified a large number of
Autor:
Joan S. Brugge, Gordon B. Mills, Peter K. Sorger, Alexis L. Scott, Deborah A. Dillon, Matthew D. Poskus, Shailja Pathania, Jia-Ren Lin, Laura M. Selfors, Ioannis K. Zervantonakis
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Factors stemming from the tumor microenvironment can modulate drug resistance. Therefore, rational approaches to design efficacious targeted therapies are needed. Here, we show that fibroblasts reduce lapatinib sensitivity in a subset of
Autor:
Xuan Liu, Patrick A. Cosgrove, Philip J. Moos, Jeffrey T. Chang, Sunil Sharma, Pierre Wallet, Gemalene Sunga, Maura Rossetti, Gajendra Shrestha, Lance Pflieger, Andrea Bild, David D. Stenehjem, Jason I. Griffiths, Neena A. Leggett, Jasmine A. McQuerry, Frederick R. Adler
Publikováno v:
Proc Natl Acad Sci U S A
The extent to which immune cell phenotypes in the peripheral blood reflect within-tumor immune activity prior to and early in cancer therapy is unclear. To address this question, we studied the population dynamics of tumor and immune cells, and immun
Autor:
Wayne A. Cabral, Maria B. Cubria, Ara Nazarian, Pramod Kamalapathy, Amanda J. DuBose, Aidin Masoudi, Michael R. Erdos, Ramin Oftadeh, Sebastian Suarez, Francis S. Collins, Brian D. Snyder, Lamya Karim
Publikováno v:
Proc Natl Acad Sci U S A
Hutchinson–Gilford progeria syndrome (HGPS) is a uniformly fatal condition that is especially prevalent in skin, cardiovascular, and musculoskeletal systems. A wide gap exists between our knowledge of the disease and a promising treatment or cure.
Autor:
Dirk Scheele, Tony Stöcker, René Hurlemann, Torge Dellert, Mari Babasiz, Ulrich Ettinger, Angela Herscheid, Laura Remmersmann, Juergen Hennig, Johannes Schultz, Ann-Kathrin Kreuder, Nina Marsh, Alexandra Philipsen, Ruediger Stirnberg
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 117(21), 11781-11787 (2020). doi:10.1073/pnas.1920147117
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Benzodiazepines (BZDs) represent the gold standard of anxiolytic pharmacotherapy; however, their clinical benefit is limited by side effects and addictive potential. Consequently, there is an urgent need to develop novel and safe anxiolytics. The pep