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Autor:
Wayne A. Cabral, Maria B. Cubria, Ara Nazarian, Pramod Kamalapathy, Amanda J. DuBose, Aidin Masoudi, Michael R. Erdos, Ramin Oftadeh, Sebastian Suarez, Francis S. Collins, Brian D. Snyder, Lamya Karim
Publikováno v:
Proc Natl Acad Sci U S A
Hutchinson–Gilford progeria syndrome (HGPS) is a uniformly fatal condition that is especially prevalent in skin, cardiovascular, and musculoskeletal systems. A wide gap exists between our knowledge of the disease and a promising treatment or cure.
Autor:
Dirk Scheele, Tony Stöcker, René Hurlemann, Torge Dellert, Mari Babasiz, Ulrich Ettinger, Angela Herscheid, Laura Remmersmann, Juergen Hennig, Johannes Schultz, Ann-Kathrin Kreuder, Nina Marsh, Alexandra Philipsen, Ruediger Stirnberg
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 117(21), 11781-11787 (2020). doi:10.1073/pnas.1920147117
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Benzodiazepines (BZDs) represent the gold standard of anxiolytic pharmacotherapy; however, their clinical benefit is limited by side effects and addictive potential. Consequently, there is an urgent need to develop novel and safe anxiolytics. The pep
Publikováno v:
Proceedings of the National Academy of Sciences. 115
The ability to abandon old strategies and adopt new ones is essential for survival in a constantly changing environment. While previous studies suggest the importance of the prefrontal cortex and some subcortical areas in the generation of strategy-s
Publikováno v:
Proceedings of the National Academy of Sciences. 110:16987-16992
Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, tissue eosinophilia, overproduction of cysteinyl leukotrienes (cysLTs), and respiratory reactions to nonselective cyclooxygenase (COX) inhibitors. Ex vivo studies suggest that
Autor:
Takeshi Miyamoto, Randall S. Johnson, Pierre Chambon, Hiroya Kanagawa, Yoshiteru Miyauchi, Toshimi Tando, Yuiko Sato, Atsuhiro Fujie, Kana Miyamoto, Hideo Morioka, Tami Kobayashi, Shigeaki Kato, Yoshiaki Toyama, Morio Matsumoto, Wu Hao, Tomoaki Mori, Shigeyuki Yoshida, Eri Katsuyama
Publikováno v:
Proceedings of the National Academy of Sciences. 110:16568-16573
In women, estrogen deficiency after menopause frequently accelerates osteoclastic bone resorption, leading to osteoporosis, the most common skeletal disorder. However, mechanisms underlying osteoporosis resulting from estrogen deficiency remain large
Autor:
Katrin Groebke Zbinden, Claas A. Meyer, Jean-Luc Moreau, Tatyana D. Sotnikova, Sean Durkin, Bernhard Bettler, Florent G. Revel, Sylvie Chaboz, Bruno Pouzet, Roger David Norcross, Amyaouch Bradaia, Raul R. Gainetdinov, Marc G. Caron, Marius C. Hoener, Veit Metzler, Laurence Ozmen, Gerhard Trube, Joseph G. Wettstein, Roland Mory
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and β-phenylethylamine, has proven to be an important modulator of the dopaminergic system and is considered a promisi
Autor:
Ruibao Ren, Shu-Min Xiong, Yang Liang, Jian-Qing Mi, Ping Liu, Lin Shi, Chuanfeng Wu, Lijuan Zhao, Yue-Ying Wang, Sai Juan Chen, Zhu Chen
Publikováno v:
Proceedings of the National Academy of Sciences. 108:2450-2455
The full-length AML1-ETO ( AE ) fusion gene resulting from t(8;21)(q22;q22) in human acute myeloid leukemia (AML) is not sufficient to induce leukemia in animals, suggesting that additional mutations are required for leukemogenesis. We and others hav
Publikováno v:
Proceedings of the National Academy of Sciences. 107:20115-20119
Sexually dimorphic nociception and opioid antinociception is very pervasive but poorly understood. We had demonstrated that spinal morphine antinociception in females, but not males, requires the concomitant activation of spinal μ- and κ-opioid rec
Publikováno v:
Proceedings of the National Academy of Sciences. 106:15079-15084
Scientific understanding of social pain—the hurt feelings resulting from social rejection, separation, or loss—has been facilitated by the hypothesis that such feelings arise, in part, from some of the same neural and neurochemical systems that g
Autor:
Neil Sen, Paula Q. Barrett, Robert M. Carey, Xiangdong Chen, Edmund M. Talley, Lucinda A. Davies, Nick A. Guagliardo, Changlong Hu, Douglas A. Bayliss
Publikováno v:
Proceedings of the National Academy of Sciences. 105:2203-2208
When inappropriate for salt status, the mineralocorticoid aldosterone induces cardiac and renal injury. Autonomous overproduction of aldosterone from the adrenal zona glomerulosa (ZG) is also the most frequent cause of secondary hypertension. Yet, th