Zobrazeno 1 - 10
of 95
pro vyhledávání: ''
Autor:
Wei Wang, Jiadong Wang, Jun Zhan, Xiao Albert Zhou, Jiadong Zhou, Changfeng Chen, Yan Wang, Long Zhao, Wenjia Zhang, Donghao Xu, Weibin Wang, Zhanlong Shen, Ruoshi Yuan, Chanyi Shi, Yingjiang Ye, Guihui Yu
Publikováno v:
Proc Natl Acad Sci U S A
Aberrant programmed cell death protein 1 (PD-1) expression on the surface of T cells is known to inhibit T cell effector activity and to play a pivotal role in tumor immune escape; thus, maintaining an appropriate level of PD-1 expression is of great
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Protein homeostasis is fundamental to the functioning of all living cells. Perturbation of the homeostasis, or proteotoxicity, plays an important role in the pathogenesis of amyotrophic lateral sclerosis and related neurodegenerative dis
Publikováno v:
Proc Natl Acad Sci U S A
The p53 tumor suppressor protein is a transcription factor and master stress response mediator, and it is subject to reduction-oxidation (redox)-dependent regulation. The P47S variant of TP53, which exists primarily in African-descent populations, as
Autor:
Li Rui, Yu Huang, Mei Li Ng, Tian Lan, Collin Tran, Qi Chen, Mathew A. Vadas, Anthony S. Don, Yanfei Qi, Sishan Yan, Min Li, Yufei Li, Long Hoa Chung, Philip J. Hogg, Carol Wadham, James G. Burchfield, Pu Xia, Gulibositan Aji, Wei Wang, Jinbiao Chen, Timothy A. Couttas, Xin Gao, Da Liu, Jennifer R. Gamble
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Hepatic insulin resistance is a chief pathogenic determinant in the development of type 2 diabetes, which is often associated with abnormal hepatic lipid regulation. Sphingolipids are a class of essential lipids in the liver, where sphin
Autor:
Chen Feng Qi, Yu Chih Peng, Yang Cheng, Xiangyu Yao, Sonja M. Best, Xiao He, Timothy G. Myers, Lu Xia, Cui Zhang, Ruili Huang, Wenxiang Sun, Brajesh K. Singh, Rong Fu Wang, Carole A. Long, Keyla C. Tumas, Jian Wu, Silvia Bolland, Channe Gowda, Xin-zhuan Su, Xiao Yu
Publikováno v:
Proc Natl Acad Sci U S A
Malaria infection induces complex and diverse immune responses. To elucidate the mechanisms underlying host–parasite interaction, we performed a genetic screen during early (24 h) Plasmodium yoelii infection in mice and identified a large number of
Autor:
Abinaya Rajendran, Hema P Bagul, Babukrishna Maniyadath, Arushi Shukla, Tandrika Chattopadhyay, Arindam Chakraborty, Srikanth Budnar, Ullas Kolthur-Seetharam, Siddhesh S. Kamat, Namrata Shukla
Publikováno v:
Proc Natl Acad Sci U S A
Inefficient physiological transitions are known to cause metabolic disorders. Therefore, investigating mechanisms that constitute molecular switches in a central metabolic organ like the liver becomes crucial. Specifically, upstream mechanisms that c
Autor:
Tamás F. Freund, William L. Klein, Lindsay A. Welikovitch, János Lőke, A. Claudio Cuello, Sonia Do Carmo, Zsófia Maglóczky, Janice C. Malcolm
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance This work provides evidence that soluble and oligomeric amyloid protein stokes neuronal inflammation during the earliest stages of Alzheimer’s disease. Identifying neuron-derived factors that engage the brain’s immune system will pro
Autor:
Marco Bolis, Rostyslav Kuzyakiv, Raffaella Santoro, Karolina Pietrzak, Guido Sauter, Ronald Simon, Rossana Aprigliano, Jean-Philippe Theurillat, Dominik Bär
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The cell of origin and the temporal order of oncogenic events in tumors play important roles for disease state. This is of particular interest for PCa due to its highly variable clinical outcome. However, these features are difficult to
Autor:
Xueying Zhang, Lili Pian, Beifen Shen, Guihua Qiu, Huanling Cao, Yaolin Zhang, Jing-Ru Huang, Xuetao Cao, Jie Dong, Xin Li, Jian Liu, Zhe Xu, Yawei Zhao, Huang Xiaofeng, Lu Guo, Jiyan Zhang, Xiaomin Ying, Weiping J Zhang, Hong-Xia Wang
Publikováno v:
Proc Natl Acad Sci U S A
Neddylation is a ubiquitination-like pathway that controls cell survival and proliferation by covalently conjugating NEDD8 to lysines in specific substrate proteins. However, the physiological role of neddylation in mammalian metabolism remains elusi
Autor:
Seung-Min Kim, Joo Young Lee, Han Chang Kang, Woo-Young Kim, Cheol-Jung Lee, Dae Joon Kim, Juhee Park, Sung-Jun Cho, Hye Suk Lee, Sun-Mi Yoo, Hyun-Jung An, Ga-Eun Lee, Yong-Yeon Cho
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The physiological relevance of STAT2 (a member of STAT family) in melanoma formation is clearly shown using a human skin tissue array. Moreover, FBXW7-mediated STAT2 protein stability regulation via ubiquitination is shown to play an ess