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pro vyhledávání: ''
Autor:
Yelena Kravtsova-Ivantsiv, Ofer Ben Itzhak, Aaron Ciechanover, Eli Pikarsky, Gilad Goldhirsh, Alexandra Ivantsiv, Yong Tae Kwon
Publikováno v:
Proc Natl Acad Sci U S A
Nuclear factor–ĸB (NF-ĸB) transcription factor is a family of essential regulators of the immune response and cell proliferation and transformation. A typical factor is a heterodimer made of either p50 or p52, which are limited processing product
Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein
Autor:
Sabrina Lusvarghi, Andaleeb Sajid, Eduardo E. Chufan, Biebele Abel, Stewart R. Durell, Megumi Murakami, Suresh V. Ambudkar, Michael M Gottesman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The multidrug transporter P-glycoprotein protects tissues from xenobiotics and other toxic compounds by pumping them out of cells. This transporter has been implicated in altering the bioavailability of chemotherapeutic drugs and in the
Autor:
Yeap Ng, Stephen J. Lockett, George Chrisafis, Roberto Weigert, Tianhong Wang, Alexander N. Gasparski, Stavroula Mili, Konstadinos Moissoglu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Specific RNAs are enriched at protrusive regions of migrating cells. This localization is important for cell migration on 2D surfaces. However, in vivo, tumor cells navigate complex 3D environments often in collective groups. Here, we in
Publikováno v:
Proc Natl Acad Sci U S A
Polyploidal giant cancer cells (PGCCs) are multinucleated chemoresistant cancer cells found in heterogeneous solid tumors. Due in part to their apparent dormancy, the effect of PGCCs on cancer progression has remained largely unstudied. Recent studie
Autor:
Ta Sen Yeh, Shih Chiang Huang, Wen-Ching Wang, Hsin Hung Cheng, Ya Yun Syu, Lin Lu Tseng, Chiou-Hwa Yuh, Hsing Jien Kung, Chih Pin Chuu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Gastric cancer (GC), a deadly malignancy in the world, particularly in East Asia, remains a major clinical challenge given a lack of effective targeted treatments for advanced HER2-negative cases (80 to 88%). This work uncovers a PHF8/c-
Autor:
Li Rui, Yu Huang, Mei Li Ng, Tian Lan, Collin Tran, Qi Chen, Mathew A. Vadas, Anthony S. Don, Yanfei Qi, Sishan Yan, Min Li, Yufei Li, Long Hoa Chung, Philip J. Hogg, Carol Wadham, James G. Burchfield, Pu Xia, Gulibositan Aji, Wei Wang, Jinbiao Chen, Timothy A. Couttas, Xin Gao, Da Liu, Jennifer R. Gamble
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Hepatic insulin resistance is a chief pathogenic determinant in the development of type 2 diabetes, which is often associated with abnormal hepatic lipid regulation. Sphingolipids are a class of essential lipids in the liver, where sphin
Publikováno v:
Proc Natl Acad Sci U S A
Interhomolog recombination (IHR) occurs spontaneously in somatic human cells at frequencies that are low but sufficient to ameliorate some genetic diseases caused by heterozygous mutations or autosomal dominant mutations. Here we demonstrate that DNA
Autor:
Qianqian Zhang, Gongyi Zhang, Philippa Marrack, Zhongzhou Chen, Tengyao Song, Srinivas Ramachandran, Thomas Danhorn, Haolin Liu, John W. Kappler, Carrie Happoldt, Xinjian Liu, Tzu L. Phang, Ting-Hui Tu, Nova Fong, Ralf Janknecht, Sangphil Oh, Pirooz V. Parsa, Laura Harmacek, Qian Zhang, Brian O’Conner, Schuyler Lee, Chuan-Yuan Li, Sonia M. Leach
Publikováno v:
Proc Natl Acad Sci U S A
More than 30% of genes in higher eukaryotes are regulated by RNA polymerase II (Pol II) promoter proximal pausing. Pausing is released by the positive transcription elongation factor complex (P-TEFb). However, the exact mechanism by which this occurs
Autor:
Kirsty M. McLaughlin, Tamas Sessler, Peter Gallagher, Emma M. Kerr, Wendy L. Allen, Alexander J. McIntyre, Gemma M.A. Gregg, Vicky M. Coyle, Gerard P. Quinn, Melissa Labonte-Wilson, Nyree Crawford, Daniel B. Longley, Jamie Z. Roberts, Andrea Lees, Fiammetta Falcone, Mark Wappett, Patrick G. Johnston, Christopher McCann, Katherine McAllister, Caitriona Holohan, Laurence J. Egan, Aideen E. Ryan, Philip D Dunne, Simon S. McDade
Publikováno v:
Lees, A, McIntyre, A J, Crawford, N T, Falcone, F, McCann, C, Holohan, C, Quinn, G P, Roberts, J Z, Sessler, T, Gallagher, P F, Gregg, G M A, McAllister, K, McLaughlin, K M, Allen, W L, Egan, L J, Ryan, A E, Labonte-Wilson, M J, Dunne, P D, Wappett, M, Coyle, V M, Johnston, P G, Kerr, E M, Longley, D B & McDade, S S 2020, ' The pseudo-caspase FLIP(L) regulates cell fate following p53 activation ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 30, pp. 17808–17819 . https://doi.org/10.1073/pnas.2001520117
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
p53 is the most frequently mutated, well-studied tumor-suppressor gene, yet the molecular basis of the switch from p53-induced cell-cycle arrest to apoptosis remains poorly understood. Using a combination of transcriptomics and functional genomics, w
Autor:
Preeti Sharma, Venkata V.V.R. Marada, Steven P. Wolf, Qi Cai, Karin Schreiber, David M. Kranz, Hans Schreiber, Henrik Clausen, Yanran He, Monika Kizerwetter
Publikováno v:
Proc Natl Acad Sci U S A
The potency of adoptive T cell therapies targeting the cell surface antigen CD19 has been demonstrated in hematopoietic cancers. It has been difficult to identify appropriate targets in nonhematopoietic tumors, but one class of antigens that have sho