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pro vyhledávání: '"35"'
Publikováno v:
Proceedings of the National Academy of Sciences. 92:7485-7489
The lacZ transgenic mouse (Muta mouse) model was used to examine the timing of ethylnitrosourea (ENU)-induced mutations in germ cells. The spectrum of mutations was also determined. Animals received five daily treatments with ENU at 50 mg/kg and were
Autor:
Stacy M. Horner, Hasan Imam, Alexa B. R. McIntyre, Aleem Siddiqui, Jae Young Jang, Geon-Woo Kim, Nandan S. Gokhale, Mohsin Khan, Christopher E. Mason, Seong-Jun Kim
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 35
N6-methyladenosine (m(6)A) RNA methylation is the most abundant epitranscriptomic modification of eukaryotic messenger RNAs (mRNAs). Previous reports have found m(6)A on both cellular and viral transcripts and defined its role in regulating numerous
Autor:
Thea Norman, Tsotne Javahishvili, Stuart Bussell, David C. Litzinger, Stephanie Chu, Bruce E. Kimmel, Ricky Lieu, Sami Kaphle, Bee-Cheng Sim, Peter G. Schultz, Thomas L. Daniel, Mike Ong, Anna-Maria A. Hays Putnam, Zhenwei Maio, Ying Buechler, Richard D. DiMarchi, Ho Cho, Andrew R. Hoffman, Guillermo Viramontes, Paola Castiglioni, Douglas W. Axelrod, Becky Gc, Vadim Kraynov, Nick Knudsen
Publikováno v:
Proceedings of the National Academy of Sciences. 108:9060-9065
The ribosomal incorporation of nonnative amino acids into polypeptides in living cells provides the opportunity to endow therapeutic proteins with unique pharmacological properties. We report here the first clinical study of a biosynthetic protein pr
Autor:
H. B. Gururaj, Vinod Kumar, R. Parimalan, Parvatam Giridhar, B. C. Narasimha Prasad, G. A. Ravishankar
Publikováno v:
Proceedings of the National Academy of Sciences. 103:13315-13320
Capsaicin is a unique alkaloid of the plant kingdom restricted to the genus Capsicum . Capsaicin is the pungency factor, a bioactive molecule of food and of medicinal importance. Capsaicin is useful as a counterirritant, antiarthritic, analgesic, ant
Autor:
Robert G. Martin, Judah L. Rosner
Publikováno v:
Proceedings of the National Academy of Sciences. 92:5456-5460
Elevated expression of the marORAB multiple antibiotic-resistance operon enhances the resistance of Escherichia coli to various medically significant antibiotics. Transcription of the operon is repressed in vivo by the marR-encoded protein, MarR, and
Autor:
Larry W. Hardy, Ellen Nalivaika
Publikováno v:
Proceedings of the National Academy of Sciences. 89:9725-9729
The substrate preference of recombinant Escherichia coli thymidylate synthase (TS) has been altered from 2'-deoxyuridylate (dUMP) to 2'-deoxycytidylate (dCMP) by site-directed mutagenesis of the codon for Asn177, which was changed to aspartic acid. T
Autor:
Lucia B. Rothman-Denes
Publikováno v:
Proceedings of the National Academy of Sciences. 110:19662-19663
Much of the mechanistic foundations of our knowledge of regulation of gene expression at the transcriptional level have been provided by Escherichia coli and its phages. E. coli RNA polymerase ( Eco RNAP) is a multisubunit enzyme composed of a cataly
Autor:
Jay D. Gralla, James E. Stefano
Publikováno v:
Proceedings of the National Academy of Sciences. 79:1069-1072
Mutations have been constructed that delete either one or two base pairs near position -19 in the lac ps promoter. Deletion of either of two adjacent base pairs increases the rates of open complex formation by nearly on order of magnitude. Two promot
Publikováno v:
Proceedings of the National Academy of Sciences. 53:517-524
Polycyclic aromatic hydrocarbons exhibit striking biological effects in mammalian organisms, e.g., they may act as carcinogens. The biochemical mechanism by which they exert this influence, however, remains obscure. While the literature on hydrocarbo