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Autor:
Pawan Malhotra, Pradeep Kumar Sheokand, Shailja Singh, Asif Mohmmed, Prakhar Agrawal, Vaibhav Sharma, Ekta Saini, Inderjeet Kaur
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009750 (2021)
PLoS Pathogens
PLoS Pathogens
The human malaria parasite, Plasmodium falciparum possesses unique gliding machinery referred to as the glideosome that powers its entry into the insect and vertebrate hosts. Several parasite proteins including Photosensitized INA-labelled protein 1
Autor:
Benjamin Luttge, Kien Nguyen, Won-Kyung Cho, Jonathan Karn, Meenakshi Shukla, Curtis Dobrowolski
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1010014 (2021)
PLoS Pathogens, Vol 17, Iss 10, p e1010014 (2021)
One strategy for a functional cure of HIV-1 is “block and lock”, which seeks to permanently suppress the rebound of quiescent HIV-1 by epigenetic silencing. For the bivalent promoter in the HIV LTR, both histone 3 lysine 27 tri-methylation (H3K27
Autor:
Jennifer Hosmer, Marufa Nasreen, Rabeb Dhouib, Ama-Tawiah Essilfie, Horst Joachim Schirra, Anna Henningham, Emmanuelle Fantino, Peter Sly, Alastair G. McEwan, Ulrike Kappler
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1010209 (2022)
PLoS Pathogens, Vol 18, Iss 1, p e1010209 (2022)
Haemophilus influenzae (Hi) infections are associated with recurring acute exacerbations of chronic respiratory diseases in children and adults including otitis media, pneumonia, chronic obstructive pulmonary disease and asthma. Here, we show that pe
Autor:
Lei lin, Qiming Li, Mohammad A. Mir, Austin D. Royster, Zekun Wang, Songyang Ren, Safder S. Ganaie, Jianming Qiu, Sichen Liu, Sheema Mir
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1010007 (2021)
PLoS Pathogens, Vol 17, Iss 10, p e1010007 (2021)
Hantavirus nucleocapsid protein (NP) inhibits protein kinase R (PKR) dimerization by an unknown mechanism to counteract its antiviral responses during virus infection. Here we demonstrate that NP exploits an endogenous PKR inhibitor P58IPK to inhibit
Autor:
Susan R. Ross, Nicolás Sarute
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009605 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009605 (2021)
Autor:
Gough G. Au, Angela R. Harrison, Glenn A. Marsh, Gregory W. Moseley, Stephen M. Rawlinson, Cassandra T. David, Megan Dearnley, Diane Green, Shawn Todd
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009636 (2021)
PLoS Pathogens, Vol 17, Iss 6, p e1009636 (2021)
Many viruses target signal transducers and activators of transcription (STAT) 1 and 2 to antagonise antiviral interferon signalling, but targeting of signalling by other STATs/cytokines, including STAT3/interleukin 6 that regulate processes important
Autor:
Mark R. Chance, Miroslava Kacirova, Jiri G. Safar, Mohammad Khursheed Siddiqi, Chae Kim, Janna Kiselar, Jen Bohon, Tracy Haldiman, Benlian Wang
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009642 (2021)
PLoS Pathogens
PLoS Pathogens
There is a limited understanding of structural attributes that encode the iatrogenic transmissibility and various phenotypes of prions causing the most common human prion disease, sporadic Creutzfeldt-Jakob disease (sCJD). Here we report the detailed
Autor:
Nathan A. Moore, Giulia Dowgier, Liliana Echavarría-Consuegra, Katherine A. Brown, Ian Brierley, Andrew E. Firth, Nicole Doyle, Charlotte Lefèvre, Sarah Keep, Georgia M. Cook, Nerea Irigoyen, Erica Bickerton, Stuart G. Siddell, Krzysztof Franaszek, Benjamin G. Hale, Idoia Busnadiego
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009644 (2021)
PLoS Pathogens, Vol 17, Iss 6, p e1009644 (2021)
Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by unfolded proteins in the endoplasmic reticulum (ER) due to high ER load. We have used RNA sequencing and ribosom
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009670 (2021)
PLoS Pathogens
PLoS Pathogens
KDM4A is a histone lysine demethylase that has been described as an oncogene in various types of cancer. The importance of KDM4A-mediated epigenetic regulation in tumorigenesis is just emerging. Here, by using Kaposi’s sarcoma associated herpesviru
Autor:
Mariel Kleer, Rory P. Mulloy, Carolyn-Ann Robinson, Danyel Evseev, Maxwell P. Bui-Marinos, Elizabeth L. Castle, Arinjay Banerjee, Samira Mubareka, Karen Mossman, Jennifer A. Corcoran
Publikováno v:
PLOS Pathogens. 18:e1010724
A dysregulated proinflammatory cytokine response is characteristic of severe coronavirus infections caused by SARS-CoV-2, yet our understanding of the underlying mechanism responsible for this imbalanced immune response remains incomplete. Processing