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Autor:
Damien Glon, Géraldine Vilmen, Daniel Perdiz, Eva Hernandez, Guillaume Beauclair, Frédérique Quignon, Clarisse Berlioz-Torrent, Vincent Maréchal, Christian Poüs, Marion Lussignol, Audrey Esclatine
Publikováno v:
PLoS Pathogens
PLoS Pathogens, 2022, 18 (3), pp.e1010371. ⟨10.1371/journal.ppat.1010371⟩
PLoS Pathogens, 2022, 18 (3), pp.e1010371. ⟨10.1371/journal.ppat.1010371⟩
Innate immunity constitutes the first line of defense against viruses, in which mitochondria play an important role in the induction of the interferon (IFN) response. BHRF1, a multifunctional viral protein expressed during Epstein-Barr virus reactiva
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010097 (2021)
PLoS Pathogens
PLoS Pathogens
Streptococcus pyogenes (group A Streptococcus) is a globally disseminated and human-adapted bacterial pathogen that causes a wide range of infections, including scarlet fever. Scarlet fever is a toxin-mediated disease characterized by the formation o
Autor:
Wentong Cai, Hongwei Gu, Xinyang Zhang, Xiaoyang Zhang, Xuwang Cai, Jie Luo, Ganwu Li, Xiao Hu
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1010005 (2021)
PLoS Pathogens, Vol 17, Iss 10, p e1010005 (2021)
Uropathogenic Escherichia coli (UPEC) deploy an array of virulence factors to successfully establish urinary tract infections. Hemolysin is a pore-forming toxin, and its expression correlates with the severity of UPEC infection. Two-component signali
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009581 (2021)
PLoS Pathogens
PLoS Pathogens
The switch between HIV latency and productive transcription is regulated by an auto-feedback mechanism initiated by the viral trans-activator Tat, which functions to recruit the host transcription elongation factor P-TEFb to proviral HIV. A heterodim
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009936 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009936 (2021)
While Entamoeba histolytica (Eh)-induced pro-inflammatory responses are critical in disease pathogenesis, the downstream signaling pathways that subsequently dampens inflammation and the immune response remains unclear. Eh in contact with macrophages
Autor:
Yaohua Fan, Zhihao Ding, Xulin Chen, Pin Wan, Geng Li, Qiwei Zhang, Keli Chen, Wenbiao Wang, Pan Pan, Zhenyang Yu, Zhen Luo, Zizhao Lao, Muhammad Adnan Shereen, Luping Lin, Miaomiao Shen, Weiwei Ge, Jianguo Wu
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 7, p e1008603 (2021)
PLoS Pathogens, Vol 17, Iss 7, p e1008603 (2021)
Dengue virus (DENV) is a mosquito-borne pathogen that causes a spectrum of diseases including life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular leakage is a common clinical crisis in DHF/DSS patients and highly
Autor:
Susan Moir, Rafael Cubas, Aarthi Talla, Margaret H. O’Connor, Carmen N. Nichols, Elias K. Haddad, Virginie Tardif, Brian Richardson, Mark J. Cameron, Mike Fang, Marita Chakhtoura
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009732 (2021)
PLoS Pathogens
PLoS Pathogens, 2021, 17 (7), pp.e1009732. ⟨10.1371/journal.ppat.1009732⟩
PLoS Pathogens, Public Library of Science, 2021, 17 (7), pp.e1009732. ⟨10.1371/journal.ppat.1009732⟩
PLoS Pathogens
PLoS Pathogens, 2021, 17 (7), pp.e1009732. ⟨10.1371/journal.ppat.1009732⟩
PLoS Pathogens, Public Library of Science, 2021, 17 (7), pp.e1009732. ⟨10.1371/journal.ppat.1009732⟩
We have recently demonstrated that the function of T follicular helper (Tfh) cells from lymph nodes (LN) of HIV-infected individuals is impaired. We found that these cells were unable to provide proper help to germinal center (GC)-B cells, as observe
Autor:
Susan R. Ross, Nicolás Sarute
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009605 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009605 (2021)
Autor:
Gough G. Au, Angela R. Harrison, Glenn A. Marsh, Gregory W. Moseley, Stephen M. Rawlinson, Cassandra T. David, Megan Dearnley, Diane Green, Shawn Todd
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009636 (2021)
PLoS Pathogens, Vol 17, Iss 6, p e1009636 (2021)
Many viruses target signal transducers and activators of transcription (STAT) 1 and 2 to antagonise antiviral interferon signalling, but targeting of signalling by other STATs/cytokines, including STAT3/interleukin 6 that regulate processes important
Autor:
Lan Yakoumatos, Kendall Stocke, Richard J. Lamont, Zackary R. Fitzsimonds, Daniel P. Miller, Chengcheng Liu
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 5, p e1009598 (2021)
PLoS Pathogens, Vol 17, Iss 5, p e1009598 (2021)
Tyrosine phosphatases are often weaponized by bacteria colonizing mucosal barriers to manipulate host cell signal transduction pathways. Porphyromonas gingivalis is a periodontal pathogen and emerging oncopathogen which interferes with gingival epith