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Autor:
Sven Peine, Marissa Herrmann, Hendrik Karsten, Marc Lütgehetmann, Matthias Marget, Matin Kohsar, William W. Kwok, John Sidney, Janna Heide, Sophia Schulte, Alessandro Sette, Julian Schulze zur Wiesch, Alexandra M. Johansson, Thomas Theo Brehm
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1 (2022)
PLoS Pathogens, Vol 17, Iss 9, p e1009842 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1010220 (2022)
PLoS Pathogens, Vol 17, Iss 9, p e1009842 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1010220 (2022)
The aim of this study was to define the breadth and specificity of dominant SARS-CoV-2-specific T cell epitopes using a comprehensive set of 135 overlapping 15-mer peptides covering the SARS-CoV-2 envelope (E), membrane (M) and nucleoprotein (N) in a
Autor:
Miguel Ángel Cuesta-Geijo, Isabel García-Dorival, Ana del Puerto, Jesús Urquiza, Inmaculada Galindo, Lucía Barrado-Gil, Fátima Lasala, Ana Cayuela, Carlos Oscar S. Sorzano, Carmen Gil, Rafael Delgado, Covadonga Alonso
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1009784 (2022)
PLoS Pathogens
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Pathogens
Digital.CSIC. Repositorio Institucional del CSIC
instname
28 p.-7 fig.-- Departamento de Biotecnología.
African swine fever virus (ASFV) infectious cycle starts with the viral adsorption and entry into the host cell. Then, the virus is internalized via clathrin/dynamin mediated endocytosis and macropi
African swine fever virus (ASFV) infectious cycle starts with the viral adsorption and entry into the host cell. Then, the virus is internalized via clathrin/dynamin mediated endocytosis and macropi
Autor:
Abdullah M. Izmirly, Adam-Nicolas Pelletier, Jennifer Connors, Bhavani Taramangalam, Sawsan O. Alturki, Emma A. Gordon, Sana O. Alturki, Joshua C. Mell, Gokul Swaminathan, Vivin Karthik, Michele A. Kutzler, Esper G. Kallas, Rafick-Pierre Sekaly, Elias K. Haddad
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1009903 (2022)
PLoS Pathogens, Vol 18, Iss 1, p e1009903 (2022)
It has been estimated that more than 390 million people are infected with Dengue virus every year; around 96 millions of these infections result in clinical pathologies. To date, there is only one licensed viral vector-based Dengue virus vaccine CYD-
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 12, p e1010109 (2021)
PLoS Pathogens, Vol 17, Iss 12, p e1010109 (2021)
Autor:
Marissa Fahlberg, Cecily C. Midkiff, Hongmei Gao, Faith Schiro, Breanna Picou, Kasi E. Russell-Lodrigue, Pyone P. Aye, Kelly Goff, Krystle Hensley, Nadia A. Golden, Rudolf P. Bohm, David C. Montefiori, Lara A. Doyle-Meyers, Nicholas J. Maness, Robert V Blair, Scott C. Weaver, Joseph L. Mankowski, Alexandra Melton, Jay Rappaport, Brandon J. Beddingfield, Dawn M. Szeltner, Chad J. Roy, Kristin E Chandler, Skye Spencer, Toni Penney, Jessica A. Plante, James A. Hoxie, Hunter J Melton, Kenneth S. Plante
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010162 (2021)
PLoS Pathogens
PLoS Pathogens
The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 disease, has killed over five million people worldwide as of December 2021 with infections rising again due to the emergence of highly transmissible variants. Animal models that faithf
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 12 (2021)
PLoS Pathogens, Vol 17, Iss 12, p e1010065 (2021)
PLoS Pathogens, Vol 17, Iss 12 (2021)
PLoS Pathogens, Vol 17, Iss 12, p e1010065 (2021)
Dengue is a mosquito-borne disease caused by dengue virus (DENV), where four serotypes can infect humans. Most DENV infections are self-resolving, but in some individuals, severe dengue characterised by a sudden increase in haematocrit, rapid decreas
Autor:
Patricia Almendro-Vázquez, Rocio Laguna-Goya, Maria Ruiz-Ruigomez, Alberto Utrero-Rico, Antonio Lalueza, Guillermo Maestro de la Calle, Pilar Delgado, Luis Perez-Ordoño, Eva Muro, Juan Vila, Isabel Zamarron, Miguel Moreno-Batanero, Marta Chivite-Lacaba, Francisco Javier Gil-Etayo, Carmen Martín-Higuera, María Ángeles Meléndez-Carmona, Carlos Lumbreras, Irene Arellano, Balbino Alarcon, Luis Miguel Allende, Jose Maria Aguado, Estela Paz-Artal
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 12, p e1010211 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Pathogens, Vol 17, Iss 12, p e1010211 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
The timing of the development of specific adaptive immunity after natural SARS-CoV-2 infection, and its relevance in clinical outcome, has not been characterized in depth. Description of the long-term maintenance of both cellular and humoral response
Autor:
Yangming Song, Haixiang Huang, Yuzhen Hu, Jiwen Zhang, Fang Li, Xin Yin, Jianzhong Shi, Yanbing Li, Chengjun Li, Dongming Zhao, Hualan Chen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010141 (2021)
PLoS Pathogens
PLoS Pathogens
Influenza virus infection is dependent on host cellular factors, and identification of these factors and their underlying mechanisms can provide important information for the development of strategies to inhibit viral infection. Here, we used a highl
Autor:
Takaharu Ueno, Tadaki Suzuki, Sameh Lotfi, Masateru Hiyoshi, Jutatip Panaampon, Shinya Suzu, Atae Utsunomiya, Osamu Noyori, Masahito Tokunaga, Yorifumi Satou, Hideki Hasegawa, Jun-ichi Fujisawa, Naofumi Takahashi, Seiji Okada, Yuetsu Tanaka, Masao Matsuoka, Yuko Sato, Youssef M. Eltalkhawy, Jun-ichirou Yasunaga
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1010126 (2021)
PLoS Pathogens
PLoS Pathogens
Human T-cell leukemia virus type 1 (HTLV-1) infects target cells primarily through cell-to-cell routes. Here, we provide evidence that cellular protein M-Sec plays a critical role in this process. When purified and briefly cultured, CD4+ T cells of H
Autor:
Marine J. Petit, Ariana A. Nagainis, Oanh H. Pham, Priya S. Shah, Matthew Kenaston, Adam T Fishburn
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 11, p e1010100 (2021)
PLoS pathogens, vol 17, iss 11
PLoS Pathogens, Vol 17, Iss 11, p e1010100 (2021)
PLoS pathogens, vol 17, iss 11
Dengue virus (DENV) disruption of the innate immune response is critical to establish infection. DENV non-structural protein 5 (NS5) plays a central role in this disruption, such as antagonism of STAT2. We recently found that DENV serotype 2 (DENV2)