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Autor:
Ali Hassan, Nicolas Blanchard
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 2, p e1010212 (2022)
PLoS Pathogens, Vol 18, Iss 2, p e1010212 (2022)
It is well established that by modulating various immune functions, host infection may alter the course of concomitant inflammatory diseases, of both infectious and autoimmune etiologies. Beyond the major impact of commensal microbiota on the immune
Autor:
Abdullah M. Izmirly, Adam-Nicolas Pelletier, Jennifer Connors, Bhavani Taramangalam, Sawsan O. Alturki, Emma A. Gordon, Sana O. Alturki, Joshua C. Mell, Gokul Swaminathan, Vivin Karthik, Michele A. Kutzler, Esper G. Kallas, Rafick-Pierre Sekaly, Elias K. Haddad
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1009903 (2022)
PLoS Pathogens, Vol 18, Iss 1, p e1009903 (2022)
It has been estimated that more than 390 million people are infected with Dengue virus every year; around 96 millions of these infections result in clinical pathologies. To date, there is only one licensed viral vector-based Dengue virus vaccine CYD-
Autor:
Marissa Fahlberg, Cecily C. Midkiff, Hongmei Gao, Faith Schiro, Breanna Picou, Kasi E. Russell-Lodrigue, Pyone P. Aye, Kelly Goff, Krystle Hensley, Nadia A. Golden, Rudolf P. Bohm, David C. Montefiori, Lara A. Doyle-Meyers, Nicholas J. Maness, Robert V Blair, Scott C. Weaver, Joseph L. Mankowski, Alexandra Melton, Jay Rappaport, Brandon J. Beddingfield, Dawn M. Szeltner, Chad J. Roy, Kristin E Chandler, Skye Spencer, Toni Penney, Jessica A. Plante, James A. Hoxie, Hunter J Melton, Kenneth S. Plante
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010162 (2021)
PLoS Pathogens
PLoS Pathogens
The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 disease, has killed over five million people worldwide as of December 2021 with infections rising again due to the emergence of highly transmissible variants. Animal models that faithf
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 12 (2021)
PLoS Pathogens, Vol 17, Iss 12, p e1010065 (2021)
PLoS Pathogens, Vol 17, Iss 12 (2021)
PLoS Pathogens, Vol 17, Iss 12, p e1010065 (2021)
Dengue is a mosquito-borne disease caused by dengue virus (DENV), where four serotypes can infect humans. Most DENV infections are self-resolving, but in some individuals, severe dengue characterised by a sudden increase in haematocrit, rapid decreas
Autor:
Patricia Almendro-Vázquez, Rocio Laguna-Goya, Maria Ruiz-Ruigomez, Alberto Utrero-Rico, Antonio Lalueza, Guillermo Maestro de la Calle, Pilar Delgado, Luis Perez-Ordoño, Eva Muro, Juan Vila, Isabel Zamarron, Miguel Moreno-Batanero, Marta Chivite-Lacaba, Francisco Javier Gil-Etayo, Carmen Martín-Higuera, María Ángeles Meléndez-Carmona, Carlos Lumbreras, Irene Arellano, Balbino Alarcon, Luis Miguel Allende, Jose Maria Aguado, Estela Paz-Artal
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 12, p e1010211 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Pathogens, Vol 17, Iss 12, p e1010211 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
The timing of the development of specific adaptive immunity after natural SARS-CoV-2 infection, and its relevance in clinical outcome, has not been characterized in depth. Description of the long-term maintenance of both cellular and humoral response
Autor:
Takaharu Ueno, Tadaki Suzuki, Sameh Lotfi, Masateru Hiyoshi, Jutatip Panaampon, Shinya Suzu, Atae Utsunomiya, Osamu Noyori, Masahito Tokunaga, Yorifumi Satou, Hideki Hasegawa, Jun-ichi Fujisawa, Naofumi Takahashi, Seiji Okada, Yuetsu Tanaka, Masao Matsuoka, Yuko Sato, Youssef M. Eltalkhawy, Jun-ichirou Yasunaga
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1010126 (2021)
PLoS Pathogens
PLoS Pathogens
Human T-cell leukemia virus type 1 (HTLV-1) infects target cells primarily through cell-to-cell routes. Here, we provide evidence that cellular protein M-Sec plays a critical role in this process. When purified and briefly cultured, CD4+ T cells of H
Autor:
Catarina E. Hioe, Guangming Li, Xiaomei Liu, Ourania Tsahouridis, Xiuting He, Masaya Funaki, Jéromine Klingler, Alex F. Tang, Roya Feyznezhad, Daniel W. Heindel, Xiao-Hong Wang, David A. Spencer, Guangnan Hu, Namita Satija, Jérémie Prévost, Andrés Finzi, Ann J. Hessell, Shixia Wang, Shan Lu, Benjamin K. Chen, Susan Zolla-Pazner, Chitra Upadhyay, Raymond Alvarez, Lishan Su
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1010183 (2022)
PLoS Pathogens, Vol 18, Iss 1, p e1010183 (2022)
Antibodies are principal immune components elicited by vaccines to induce protection from microbial pathogens. In the Thai RV144 HIV-1 vaccine trial, vaccine efficacy was 31% and the sole primary correlate of reduced risk was shown to be vigorous ant
Autor:
Francisco Almanza, Jinsong Zhang, Yaroslav Tsybovsky, Erika Duggan, Max Crispin, Kshitij Wagh, John P. Nolan, Joel D. Allen, Keiko Osawa, James M. Binley, Huihui Mou, Alyssa Thomas, Alessio D'addabbo, Evan M. Cale, Emma T. Crooks, Laurent Verkoczy, Bette T. Korber
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
PLoS Pathogens, Vol 17, Iss 10, p e1009807 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1009807 (2021)
PLoS Pathogens
HIV-1 vaccine immunofocusing strategies may be able to induce broadly-reactive neutralizing antibodies (NAbs). Here, we engineered a panel of diverse, membrane-resident native HIV-1 trimers vulnerable to two broad targets—the V2 apex and fusion pep
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009936 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009936 (2021)
While Entamoeba histolytica (Eh)-induced pro-inflammatory responses are critical in disease pathogenesis, the downstream signaling pathways that subsequently dampens inflammation and the immune response remains unclear. Eh in contact with macrophages
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009818 (2021)
PLoS Pathogens
PLoS Pathogens
Cytotoxic lymphocytes produce granules armed with a set of 5 serine proteases (granzymes (Gzms)), which, together with the pore-forming protein (perforin), serve as a major defense against viral infections in humans. This granule-exocytosis pathway s