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Autor:
Abdullah M. Izmirly, Adam-Nicolas Pelletier, Jennifer Connors, Bhavani Taramangalam, Sawsan O. Alturki, Emma A. Gordon, Sana O. Alturki, Joshua C. Mell, Gokul Swaminathan, Vivin Karthik, Michele A. Kutzler, Esper G. Kallas, Rafick-Pierre Sekaly, Elias K. Haddad
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1009903 (2022)
PLoS Pathogens, Vol 18, Iss 1, p e1009903 (2022)
It has been estimated that more than 390 million people are infected with Dengue virus every year; around 96 millions of these infections result in clinical pathologies. To date, there is only one licensed viral vector-based Dengue virus vaccine CYD-
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 12 (2021)
PLoS Pathogens, Vol 17, Iss 12, p e1010065 (2021)
PLoS Pathogens, Vol 17, Iss 12 (2021)
PLoS Pathogens, Vol 17, Iss 12, p e1010065 (2021)
Dengue is a mosquito-borne disease caused by dengue virus (DENV), where four serotypes can infect humans. Most DENV infections are self-resolving, but in some individuals, severe dengue characterised by a sudden increase in haematocrit, rapid decreas
Autor:
Patricia Almendro-Vázquez, Rocio Laguna-Goya, Maria Ruiz-Ruigomez, Alberto Utrero-Rico, Antonio Lalueza, Guillermo Maestro de la Calle, Pilar Delgado, Luis Perez-Ordoño, Eva Muro, Juan Vila, Isabel Zamarron, Miguel Moreno-Batanero, Marta Chivite-Lacaba, Francisco Javier Gil-Etayo, Carmen Martín-Higuera, María Ángeles Meléndez-Carmona, Carlos Lumbreras, Irene Arellano, Balbino Alarcon, Luis Miguel Allende, Jose Maria Aguado, Estela Paz-Artal
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 12, p e1010211 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Pathogens, Vol 17, Iss 12, p e1010211 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
The timing of the development of specific adaptive immunity after natural SARS-CoV-2 infection, and its relevance in clinical outcome, has not been characterized in depth. Description of the long-term maintenance of both cellular and humoral response
Autor:
Marine J. Petit, Ariana A. Nagainis, Oanh H. Pham, Priya S. Shah, Matthew Kenaston, Adam T Fishburn
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 11, p e1010100 (2021)
PLoS pathogens, vol 17, iss 11
PLoS Pathogens, Vol 17, Iss 11, p e1010100 (2021)
PLoS pathogens, vol 17, iss 11
Dengue virus (DENV) disruption of the innate immune response is critical to establish infection. DENV non-structural protein 5 (NS5) plays a central role in this disruption, such as antagonism of STAT2. We recently found that DENV serotype 2 (DENV2)
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 11, p e1010096 (2021)
PLoS Pathogens, 2021, 17 (11), pp.e1010096. ⟨10.1371/journal.ppat.1010096⟩
PLoS Pathogens, Public Library of Science, 2021, 17 (11), pp.e1010096. ⟨10.1371/journal.ppat.1010096⟩
PLoS Pathogens, Vol 17, Iss 11, p e1010096 (2021)
PLoS Pathogens, 2021, 17 (11), pp.e1010096. ⟨10.1371/journal.ppat.1010096⟩
PLoS Pathogens, Public Library of Science, 2021, 17 (11), pp.e1010096. ⟨10.1371/journal.ppat.1010096⟩
Iron-sulfur (Fe-S) clusters are one of the most ancient and ubiquitous prosthetic groups, and they are required by a variety of proteins involved in important metabolic processes. Apicomplexan parasites have inherited different plastidic and mitochon
Autor:
Wentong Cai, Hongwei Gu, Xinyang Zhang, Xiaoyang Zhang, Xuwang Cai, Jie Luo, Ganwu Li, Xiao Hu
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1010005 (2021)
PLoS Pathogens, Vol 17, Iss 10, p e1010005 (2021)
Uropathogenic Escherichia coli (UPEC) deploy an array of virulence factors to successfully establish urinary tract infections. Hemolysin is a pore-forming toxin, and its expression correlates with the severity of UPEC infection. Two-component signali
Autor:
Jenniffer Angulo, Francisco M. Barriga, Eduard Batlle, Marcelo López-Lastra, Jorge Vera-Otarola, Estefania Castillo-Vargas
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009931 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009931 (2021)
The capped Small segment mRNA (SmRNA) of the Andes orthohantavirus (ANDV) lacks a poly(A) tail. In this study, we characterize the mechanism driving ANDV-SmRNA translation. Results show that the ANDV-nucleocapsid protein (ANDV-N) promotes in vitro tr
Autor:
Megan M Dunagan, Toru Takimoto, Nicholas T.Y. Lim, Michael M. Lutz, Yuki Kurebayashi, Masahiro Watanabe, Shringkhala Bajimaya
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009908 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009908 (2021)
Human parainfluenza virus type 1 (hPIV1) and 3 (hPIV3) cause seasonal epidemics, but little is known about their interaction with human airway cells. In this study, we determined cytopathology, replication, and progeny virion release from human airwa
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009936 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009936 (2021)
While Entamoeba histolytica (Eh)-induced pro-inflammatory responses are critical in disease pathogenesis, the downstream signaling pathways that subsequently dampens inflammation and the immune response remains unclear. Eh in contact with macrophages
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009631 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009631 (2021)
Herpes simplex virus 1 (HSV1) infects the stratified epithelia of the epidermis, oral or genital mucosa, where the main cell type is the keratinocyte. Here we have used nTERT human keratinocytes to generate a CRISPR-Cas9 knockout (KO) of the primary