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Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009936 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009936 (2021)
While Entamoeba histolytica (Eh)-induced pro-inflammatory responses are critical in disease pathogenesis, the downstream signaling pathways that subsequently dampens inflammation and the immune response remains unclear. Eh in contact with macrophages
Autor:
Gough G. Au, Angela R. Harrison, Glenn A. Marsh, Gregory W. Moseley, Stephen M. Rawlinson, Cassandra T. David, Megan Dearnley, Diane Green, Shawn Todd
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009636 (2021)
PLoS Pathogens, Vol 17, Iss 6, p e1009636 (2021)
Many viruses target signal transducers and activators of transcription (STAT) 1 and 2 to antagonise antiviral interferon signalling, but targeting of signalling by other STATs/cytokines, including STAT3/interleukin 6 that regulate processes important
Autor:
Anouk Sarr, Carsten Terjung, Gabriele Schmuck, David D. Ekale, Daniel Kulke, Lucien Rufener, Vincent N. Tanya, Germanus S. Bah, John Graham-Brown, Nicolas H. Bayang, Helena Fieseler, Ralph Krebber, Steffen Hahnel, Benjamin L. Makepeace, Youssouf M. Mfopit, Sebastian Schneckener, Martin Glenschek-Sieberth, Henrietta F. Ngangyung
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009601 (2021)
PLOS PATHOGENS
PLoS Pathogens, Vol 17, Iss 6, p e1009601 (2021)
PLOS PATHOGENS
Onchocerciasis (river blindness), caused by the filarial worm Onchocerca volvulus, is a neglected tropical disease mostly affecting sub-Saharan Africa and is responsible for >1.3 million years lived with disability. Current control relies almost enti
Autor:
Yueyue Duan, Junwu Ma, Qi Wang, Zhang Keshan, Zixiang Zhu, Xiangtao Liu, Zhang Wei, Zheng Haixue, Fan Yang, Weijun Cao, Yang Yang
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 3, p e1009366 (2021)
PLoS Pathogens, Vol 17, Iss 3, p e1009366 (2021)
The negative regulation of antiviral immune responses is essential for the host to maintain homeostasis. Jumonji domain-containing protein 6 (JMJD6) was previously identified with a number of functions during RNA virus infection. Upon viral RNA recog
Autor:
Peng Zhang, Ze Hong, Juanjuan Zhu, Jin-fu Xu, Haiyang Hu, Ye Cui, Huansha Yu, Dong Qian, Chenhui Li, Quanyi Wang, Chen Wang, Lele Zhang, Mingxing Cheng, Wei Meng, Yi Sun
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 3, p e1009401 (2021)
PLoS Pathogens, Vol 17, Iss 3, p e1009401 (2021)
The cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) has emerged as a fundamental component fueling the anti-pathogen immunity. Because of its pivotal role in initiating innate immune response, the activity of cGAS must be tightly fine-t
Autor:
Melissa A. Brown, Richard Longnecker, Cooper K. Hayes, Douglas R. Wilcox, Yuchen Yang, Grace K. Coleman
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 2, p e1009285 (2021)
PLoS Pathogens, Vol 17, Iss 2, p e1009285 (2021)
Herpes simplex virus encephalitis (HSE) is the most common cause of sporadic viral encephalitis, and despite targeted antiviral therapy, outcomes remain poor. Although the innate immune system is critical for restricting herpes simplex virus type I (
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 2, p e1009211 (2021)
PLoS Pathogens, Vol 17, Iss 2, p e1009211 (2021)
The mitochondrion is critical for the survival of apicomplexan parasites. Several major anti-parasitic drugs, such as atovaquone and endochin-like quinolones, act through inhibition of the mitochondrial electron transport chain at the coenzyme Q:cyto
Autor:
J. Pintado-Silva, J. Veloz, St Patrick Reid, Rafael Fenutria, Kenneth A. Stapleford, Ana Fernandez-Sesma, L. Carrau, D. Figueroa, Jacob S. Yount, Margarita V. Rangel, Uma Potla, T. Mutetwa, L. Zhang, Dabeiba Bernal-Rubio, Sebastian Aguirre, Tongtong Zhu, Laurence G. Webb
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 10, p e1008999 (2020)
PLoS Pathogens, Vol 16, Iss 10, p e1008999 (2020)
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus known to cause epidemics resulting in predominantly symptomatic infections, which in rare cases cause long term debilitating arthritis and arthralgia. Significant progress has been made in unde
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 10, p e1008529 (2020)
PLoS Pathogens, Vol 16, Iss 10, p e1008529 (2020)
Biofilm-based infections are difficult to treat due to their inherent resistance to antibiotic treatment. Discovering new approaches to enhance antibiotic efficacy in biofilms would be highly significant in treating many chronic infections. Exposure
Autor:
Diamond R. Guy, James L. McGrath, Edward M. Schwarz, Alec T. Salminen, Hani A. Awad, Elysia A Masters, Stephanie P. Hao, Steven R. Gill, Karen L. de Mesy Bentley, Ann L. Gill, Chad A. Galloway
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 10, p e1008988 (2020)
PLoS Pathogens, Vol 16, Iss 10, p e1008988 (2020)
Staphylococcus aureus infection of bone is challenging to treat because it colonizes the osteocyte lacuno-canalicular network (OLCN) of cortical bone. To elucidate factors involved in OLCN invasion and identify novel drug targets, we completed a hypo