Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nigel, M Hooper"'
Autor:
Isobel J Whitehouse, Deborah Brown, Herbert Baybutt, Abigail B Diack, Katherine A B Kellett, Pedro Piccardo, Jean C Manson, Nigel M Hooper
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159119 (2016)
The cellular prion protein (PrPC) has been proposed to play an important role in the pathogenesis of Alzheimer's disease. In cellular models PrPC inhibited the action of the β-secretase BACE1 on wild type amyloid precursor protein resulting in a red
Externí odkaz:
https://doaj.org/article/661eb766a5da451a8aa047e01b1089fe
Autor:
Isobel J Whitehouse, J Scott Miners, Elizabeth B C Glennon, Patrick G Kehoe, Seth Love, Katherine A B Kellett, Nigel M Hooper
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e59554 (2013)
The cellular prion protein (PrP(C)) has been implicated in the development of Alzheimer's disease (AD). PrP(C) decreases amyloid-β (Aβ) production, which is involved in AD pathogenesis, by inhibiting β-secretase (BACE1) activity. Contactin 5 (CNTN
Externí odkaz:
https://doaj.org/article/ee16e95ab5754226969dbd39ff64f1cc
Autor:
Elizabeth B C Glennon, Isobel J Whitehouse, J Scott Miners, Patrick G Kehoe, Seth Love, Katherine A B Kellett, Nigel M Hooper
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78806 (2013)
Bridging integrator 1 (BIN1) has been implicated in sporadic Alzheimer's disease (AD) by a number of genome wide association studies (GWAS) in a variety of populations. Here we measured BIN1 in frontal cortex samples from 24 sporadic AD and 24 age-ma
Externí odkaz:
https://doaj.org/article/ef52b105705747f99d93a0f22f859fb6
Autor:
Victoria Lewis, Isobel J Whitehouse, Herbert Baybutt, Jean C Manson, Steven J Collins, Nigel M Hooper
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31754 (2012)
There is increasing evidence of molecular and cellular links between Alzheimer's disease (AD) and prion diseases. The cellular prion protein, PrP(C), modulates the post-translational processing of the AD amyloid precursor protein (APP), through its i
Externí odkaz:
https://doaj.org/article/08e189dc9f87415ca7e578f29a71edff
Autor:
Nigel M. Hooper, J Scott Miners, Patrick G. Kehoe, Isobel J. Whitehouse, Seth Love, Katherine A.B. Kellett, Elizabeth B. C. Glennon
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 4, p e59554 (2013)
PLoS ONE, Vol 8, Iss 4, p e59554 (2013)
The cellular prion protein (PrP(C)) has been implicated in the development of Alzheimer's disease (AD). PrP(C) decreases amyloid-beta (Abeta) production, which is involved in AD pathogenesis, by inhibiting beta-secretase (BACE1) activity. Contactin 5
Autor:
Isobel J. Whitehouse, Jean Manson, Victoria Lewis, Steven J. Collins, Herbert Baybutt, Nigel M. Hooper
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 2, p e31754 (2012)
Lewis, V, Whitehouse, I J, Baybutt, H, Manson, J C, Collins, S J & Hooper, N M 2012, ' Cellular Prion Protein Expression Is Not Regulated by the Alzheimer's Amyloid Precursor Protein Intracellular Domain ', PLoS ONE, vol. 7, no. 2, ARTN e31754 . https://doi.org/10.1371/journal.pone.0031754
PLoS ONE, Vol 7, Iss 2, p e31754 (2012)
Lewis, V, Whitehouse, I J, Baybutt, H, Manson, J C, Collins, S J & Hooper, N M 2012, ' Cellular Prion Protein Expression Is Not Regulated by the Alzheimer's Amyloid Precursor Protein Intracellular Domain ', PLoS ONE, vol. 7, no. 2, ARTN e31754 . https://doi.org/10.1371/journal.pone.0031754
There is increasing evidence of molecular and cellular links between Alzheimer's disease (AD) and prion diseases. The cellular prion protein, PrPC, modulates the posttranslational processing of the AD amyloid precursor protein (APP), through its inhi