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Autor:
J. P. Jones, William Parker, Caroline J. Smith, Zacharoula Konsoula, John Poulton, Jasmine Cendejas Hernandez, Navneet Suda
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders. We had previously postulated that acetaminophen exposure early in life, if combined with
Autor:
Cassandra M. Wilkinson, Tiffany F. C. Kung, Frederick Colbourne, Christine A. Dirks, Glen C. Jickling
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252584 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252584 (2021)
Intracerebral hemorrhage (ICH) is a devastating insult with few effective treatments. Edema and raised intracranial pressure contribute to poor outcome after ICH. Glibenclamide blocks the sulfonylurea 1 transient receptor potential melastatin 4 (Sur1
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258800 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258800 (2021)
Background Diabetes mellitus (DM) and chronic kidney disease (CKD) are common causes of morbidity and mortality. Flaxseed contains several bioactive compounds that have been shown to possess anti-inflammatory and antioxidative properties. The aim of
Autor:
Jingxue Nai, Zhiping Li, Meiyan Yang, Siyu Ma, Xingguo Mei, Zhenbo Yang, Jinbang Zhang, Yang Yang, Jiaxin Li, Yumei Zhao, Yue Gao, Chunsheng Gao, Wei Gong, Hui Li, Fanglin Yu, Yu Li Wang
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0250670 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250670 (2021)
We developed a novel preparative method for nanoparticle albumin-bound (nab) paclitaxel with high drug loading, which was based on improved paclitaxel solubility in polyethylene glycol (PEG) and self-assembly of paclitaxel in PEG with albumin powders
Autor:
Oleksandr Maximyuk, Oleg Krishtal, Artur Romanov, D.S. Isaev, Murat Oz, Gregory L. Holmes, O Netsyk, Olha Zapukhliak
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0240074 (2021)
PLoS ONE, Vol 16, Iss 3, p e0240074 (2021)
Cholinergic modulation of hippocampal network function is implicated in multiple behavioral and cognitive states. Activation of nicotinic and muscarinic acetylcholine receptors affects neuronal excitability, synaptic transmission and rhythmic oscilla
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
Despite the need for safe and effective postoperative analgesia in neonates, research regarding pain management in neonatal rodents is relatively limited. Here, we investigate whether sustained release buprenorphine (Bup SR) effectively attenuates th
Autor:
Junhyung Kim, Gi-Hyeok Yang, Jangmi Lee, Seongsung Kwak, Won-ho Kang, Mi-Sun Park, Chang-Hoon Rhee, Woo-Chan Son
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256869 (2021)
PLoS ONE
PLoS ONE
Human serum albumin (HSA) has been widely used as a pharmaceutical excipient in Botulinum toxin serotype A (BoNT/A) products that are indicated for use in therapeutics and cosmetics. However, HSA as a human-derived material has some concerns, such as
Autor:
Ric M. Procyshyn, William G. Honer, Jessica W. Y. Yuen, Lurdes Tse, Alasdair M. Barr, Heidi N. Boyda
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0246211 (2021)
PLoS ONE
PLoS ONE
Background The second generation antipsychotic drugs represent the most common form of pharmacotherapy for schizophrenia disorders. It is now well established that most of the second generation drugs cause metabolic side-effects. Risperidone and its
Autor:
Muhammad Manko, John Idoko, Kasimu Umar Adoke, Adamu Abdullahi, Abdullahi Mohammed, Surajo Mohammed Aminu, Sani Abubakar, Sani Ibrahim, Yawale Iliyasu, Halimatu Sadiya Musa, Khalid Zahir Shah, Ahmed Adamu, Aishatu Maude Suleiman, Mohammed Faruk, Abdulmumini Hassan Rafindadi, Cheh Agustin Awasum, Rakiya Saidu, Abdullahi Jibril Randawa, Atara Ntekim
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245581 (2021)
PLoS ONE
BASE-Bielefeld Academic Search Engine
PLoS ONE
BASE-Bielefeld Academic Search Engine
Evasion of apoptosis is associated with treatment resistance and metastasis in colorectal cancer (CRC). Various cellular processes are associated with evasion of apoptosis. These include overexpression of pro-apoptotic proteins (including p53 and PD-
Autor:
Yasutoshi Hatsuda, Katsuhito Nagai, Sachiko Omotani, Michiaki Myotoku, Shuhei Fukuno, Yoshikazu Ryuno, Yoshihito Iwanami, Hiroki Konishi
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0259400 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0259400 (2021)
BackgroundThe use of enteral nutrients plays a highly important role in accurate nutrition management, but limited information is currently available on the cautionary points of semi-solid enteral nutrients.AimIn this study, we examined whether the p