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Autor:
Christian Vanhove, Karel Deblaere, Benedicte Descamps, Tom Boterberg, Giorgio Hallaert, Julie Bolcaen, Filip De Vos, Caroline Van den Broecke, Ingeborg Goethals
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248193 (2021)
PLOS ONE
PLoS ONE
PLOS ONE
PLoS ONE
Objective We investigated the potential of [18F]fluorodeoxyglucose ([18F]FDG) and [18F]Fluoromethylcholine ([18F]FCho) PET, compared to contrast-enhanced MRI, for the early detection of treatment response in F98 glioblastoma (GB) rats. Methods When G
Autor:
Se-min Choi, Hyun Ho Jeong, Jungtaek Park, Kyoung Ho Choi, Joo Suk Oh, Kiwook Kim, Young Min Oh
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0253328 (2021)
PLoS ONE
PLoS ONE
It has been reported that valproic acid (VPA) combined with therapeutic hypothermia can improve survival and neurologic outcomes in a rat asphyxial cardiac arrest model. However, neuroprotective mechanisms of such combined treatment of valproic acid
Autor:
Ashok Prabhu, Judith Huettemeister, Leif-Hendrik Boldt, Sandra C. Klaucke, Frank R. Heinzel, Philipp Lacour, Florian Blaschke, Abdul Shokor Parwani, Lars Bullinger, Sanzio Dimai, Harald Stachelscheid, Felix Hohendanner, Jan Kruse, Burkert Pieske, Lukas Semmler
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255976 (2021)
PLoS ONE
PLoS ONE
Background Cardiac injury associated with cytokine release frequently occurs in SARS-CoV-2 mediated coronavirus disease (COVID19) and mortality is particularly high in these patients. The mechanistic role of the COVID19 associated cytokine-storm for
Autor:
Maiko Ikeda, Tomio Andoh, Takahisa Goto, Tomoyuki Miyazaki, Ryo Niikura, Takahiro Mihara, Akiko Doi
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248113 (2021)
PLoS ONE
PLoS ONE
Immature neurons dominantly express the Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) rather than the K+-Cl- cotransporter isoform 2 (KCC2). The intracellular chloride ion concentration ([Cl-]i) is higher in immature neurons than in mature neurons; the
Autor:
Ningyong Xu, Viktoriya Pastukh, Mikhail Alexeyev, Troy Stevens, Dhananjay T. Tambe, Linn Ayers
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250095 (2021)
PLoS ONE
PLoS ONE
Collective migration of endothelial cells is important for wound healing and angiogenesis. During such migration, each constituent endothelial cell coordinates its magnitude and direction of migration with its neighbors while retaining intercellular
Autor:
Nasrullah Jan, Arshad Khan, Hassan Shah, Safiullah Khan, Ahsan Ali, Asadullah Madni, Muhammad Abdur Rahim, Abdul Jabar
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258141 (2021)
PLoS ONE
PLoS ONE
The present study is associated with the development of proliposomes and liposomal derived gel for enhanced solubility and permeability of diacerein. Proliposomes were developed by thin film hydration method and converted into the liposomal derived g
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250126 (2021)
PLoS ONE
PLoS ONE
Amino acid metabolism plays an important role in controlling blood pressure by regulating the production of NO and ROS. The present study examined amino acid levels in the serum of Dahl SS rats and SS.13BN rats fed a low or high salt diet. We observe
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0246019 (2021)
PLoS ONE
PLoS ONE
With population growth and aging, more and more patients with cerebral infarction have varying degrees of disability. ATP-sensitive potassium (KATP) channels regulate many cellular functions by coupling metabolic status with cell membrane electrical
Autor:
Han-Jung Chae, Myong-Ja Chung, Jong-Sik Jin, In-Yeong Kang, Hwa-Young Lee, Seon-Ah Park, Geum-Hwa Lee, The-Hiep Hoang
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250354 (2021)
PLoS ONE
PLoS ONE
Constipation is a common condition that affects individuals of all ages, and prolonged constipation needs to be prevented to avoid potential complications and reduce the additional stress on individuals with pre-medical conditions. This study aimed t
Autor:
Swaha Satpathy, Arjun Patra, Bharti Ahirwar, Muhammad Delwar Hussain, Mohsin Kazi, Mohammed S. Aldughaim
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0240068 (2021)
PLoS ONE
PLoS ONE
Pueraria tuberosa (Roxb. ex Willd.) DC., known as Indian Kudzu belongs to family Fabaceae and it is solicited as “Rasayana” drugs in Ayurveda. In the present study, we analyzed the efficacy of an ethyl acetate fraction from the tuber extract of P