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Autor:
J. P. Jones, William Parker, Caroline J. Smith, Zacharoula Konsoula, John Poulton, Jasmine Cendejas Hernandez, Navneet Suda
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders. We had previously postulated that acetaminophen exposure early in life, if combined with
Autor:
Cassandra M. Wilkinson, Tiffany F. C. Kung, Frederick Colbourne, Christine A. Dirks, Glen C. Jickling
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252584 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252584 (2021)
Intracerebral hemorrhage (ICH) is a devastating insult with few effective treatments. Edema and raised intracranial pressure contribute to poor outcome after ICH. Glibenclamide blocks the sulfonylurea 1 transient receptor potential melastatin 4 (Sur1
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
Despite the need for safe and effective postoperative analgesia in neonates, research regarding pain management in neonatal rodents is relatively limited. Here, we investigate whether sustained release buprenorphine (Bup SR) effectively attenuates th
Autor:
Ric M. Procyshyn, William G. Honer, Jessica W. Y. Yuen, Lurdes Tse, Alasdair M. Barr, Heidi N. Boyda
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0246211 (2021)
PLoS ONE
PLoS ONE
Background The second generation antipsychotic drugs represent the most common form of pharmacotherapy for schizophrenia disorders. It is now well established that most of the second generation drugs cause metabolic side-effects. Risperidone and its
Autor:
Yasutoshi Hatsuda, Katsuhito Nagai, Sachiko Omotani, Michiaki Myotoku, Shuhei Fukuno, Yoshikazu Ryuno, Yoshihito Iwanami, Hiroki Konishi
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0259400 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0259400 (2021)
BackgroundThe use of enteral nutrients plays a highly important role in accurate nutrition management, but limited information is currently available on the cautionary points of semi-solid enteral nutrients.AimIn this study, we examined whether the p
Autor:
Ashok Prabhu, Judith Huettemeister, Leif-Hendrik Boldt, Sandra C. Klaucke, Frank R. Heinzel, Philipp Lacour, Florian Blaschke, Abdul Shokor Parwani, Lars Bullinger, Sanzio Dimai, Harald Stachelscheid, Felix Hohendanner, Jan Kruse, Burkert Pieske, Lukas Semmler
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255976 (2021)
PLoS ONE
PLoS ONE
Background Cardiac injury associated with cytokine release frequently occurs in SARS-CoV-2 mediated coronavirus disease (COVID19) and mortality is particularly high in these patients. The mechanistic role of the COVID19 associated cytokine-storm for
Autor:
Ningyong Xu, Viktoriya Pastukh, Mikhail Alexeyev, Troy Stevens, Dhananjay T. Tambe, Linn Ayers
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250095 (2021)
PLoS ONE
PLoS ONE
Collective migration of endothelial cells is important for wound healing and angiogenesis. During such migration, each constituent endothelial cell coordinates its magnitude and direction of migration with its neighbors while retaining intercellular
Autor:
Nasrullah Jan, Arshad Khan, Hassan Shah, Safiullah Khan, Ahsan Ali, Asadullah Madni, Muhammad Abdur Rahim, Abdul Jabar
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258141 (2021)
PLoS ONE
PLoS ONE
The present study is associated with the development of proliposomes and liposomal derived gel for enhanced solubility and permeability of diacerein. Proliposomes were developed by thin film hydration method and converted into the liposomal derived g
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0246019 (2021)
PLoS ONE
PLoS ONE
With population growth and aging, more and more patients with cerebral infarction have varying degrees of disability. ATP-sensitive potassium (KATP) channels regulate many cellular functions by coupling metabolic status with cell membrane electrical
Autor:
Swaha Satpathy, Arjun Patra, Bharti Ahirwar, Muhammad Delwar Hussain, Mohsin Kazi, Mohammed S. Aldughaim
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0240068 (2021)
PLoS ONE
PLoS ONE
Pueraria tuberosa (Roxb. ex Willd.) DC., known as Indian Kudzu belongs to family Fabaceae and it is solicited as “Rasayana” drugs in Ayurveda. In the present study, we analyzed the efficacy of an ethyl acetate fraction from the tuber extract of P