Zobrazeno 1 - 10
of 73
pro vyhledávání: ''
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
Despite the need for safe and effective postoperative analgesia in neonates, research regarding pain management in neonatal rodents is relatively limited. Here, we investigate whether sustained release buprenorphine (Bup SR) effectively attenuates th
Autor:
Ric M. Procyshyn, William G. Honer, Jessica W. Y. Yuen, Lurdes Tse, Alasdair M. Barr, Heidi N. Boyda
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0246211 (2021)
PLoS ONE
PLoS ONE
Background The second generation antipsychotic drugs represent the most common form of pharmacotherapy for schizophrenia disorders. It is now well established that most of the second generation drugs cause metabolic side-effects. Risperidone and its
Autor:
Ashok Prabhu, Judith Huettemeister, Leif-Hendrik Boldt, Sandra C. Klaucke, Frank R. Heinzel, Philipp Lacour, Florian Blaschke, Abdul Shokor Parwani, Lars Bullinger, Sanzio Dimai, Harald Stachelscheid, Felix Hohendanner, Jan Kruse, Burkert Pieske, Lukas Semmler
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255976 (2021)
PLoS ONE
PLoS ONE
Background Cardiac injury associated with cytokine release frequently occurs in SARS-CoV-2 mediated coronavirus disease (COVID19) and mortality is particularly high in these patients. The mechanistic role of the COVID19 associated cytokine-storm for
Autor:
Maria do Socorro de Sousa Cartágenes, José Osvaldo Barbosa Neto, João Batista Santos Garcia, Lyvia Maria Rodrigues de Sousa Gomes, Rayanne Luiza Tajra Mualem Araújo, Nicolau Gregori Czeczko
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245194 (2021)
PLoS ONE
PLoS ONE
Pharmacological treatment of osteoarthritis is still inadequate due to the low efficacy of the drugs used. Dexmedetomidine via the intra-articular (i.a.) route might be an option for the treatment of osteoarthritis-associated pain. The present study
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257012 (2021)
PLoS ONE
PLoS ONE
Sodium carboxymethyl starch (CMS-Na), a kind of food additive with high degree of substitution, is also known as a prebiotic. The aim of this study was to determine the effect of CMS-Na on defecation. Constipated mouse model was prepared by loperamid
Autor:
Nashwa W. Yassa, Doaa A. Ghareeb, Sofia Khalil, Samar R. Saleh, Maha A. El Demellawy, Mohamed M. El-Sayed
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0237929 (2020)
PLoS ONE, Vol 15, Iss 8, p e0237929 (2020)
BackgroundNeuroinflammation causes neurodegenerative conditions like Alzheimer's disease (AD). Ipriflavone (IP), therapeutic compound to postmenopausal osteoporosis, has limited estrogenic activity and is accounted as AChE inhibitor. The developing o
Autor:
Sumio Hirata, Junji Saruwatari, Hiroki Ito, Ryota Tanaka, Kazuaki Taguchi, Mika Mori, Masaki Fukunaga, Keishi Yamasaki, Masaki Otagiri, Yuki Narita, Toru Maruyama, Daisuke Kadowaki, Satomi Hagiwara, Hiroshi Watanabe
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0233925 (2020)
PLoS ONE, Vol 15, Iss 6, p e0233925 (2020)
It is important to calculate the drug removal by hemodialysis (HD) for drug dosing regimens in HD patients. However, there are limited and inconsistent information about the dialyzability of drugs by HD. Therefore, the aim of our study is to evaluate
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0235046 (2020)
PLoS ONE, Vol 15, Iss 6, p e0235046 (2020)
Post-ictal emergence of slow wave EEG (electroencephalogram) activity and burst-suppression has been associated with the therapeutic effects of the electroconvulsive therapy (ECT), indicating that mere “cerebral silence” may elicit antidepressant
Autor:
Toshio Mochizuki, Tomochika Maoka, Seiji Hashimoto, Takao Koike, Tetsuya Kawata, Takashi Shigematsu
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0242332 (2020)
PLoS ONE
PLoS ONE
We have reported previously that renal hemodynamic abnormalities exist in the prediabetic stage of type II diabetic rats. At this prediabetic stage these rats have hyperinsulinemia, insulin resistance and metabolic syndrome. It is well known that ins
Autor:
Shay Henry Hornfeld, Alexey Vanichkin, Irit Gil-Ad, Abraham Weizman, Konstantin Bloch, Pnina Vardi, Shira Dar
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227879 (2020)
PLoS ONE
PLoS ONE
Accumulating evidence suggests that Alzheimer's disease is associated with brain insulin resistance, as are some other types of dementia. Intranasal insulin administration has been suggested as a potential approach to overcoming brain insulin resista