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Autor:
Zsófia Spisák, András Czurkó, Gabriella Nyitrai, Dávid Gajári, Pálma Diószegi, Tamás Z. Kincses, Tamás Spisák
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0198265 (2018)
PLoS ONE, Vol 13, Iss 5, p e0198265 (2018)
Bilateral common carotid artery occlusion (BCCAo) in the rat is a widely used animal model of vascular dementia and a valuable tool for preclinical pharmacological drug testing, although the varying degrees of acute focal ischemic lesions it induces
Autor:
Seung Baik, Kwang Ho You, Kwanjin Park, Hwancheol Son, Jae-Seung Paick, Inyoung Sun, Soo Woong Kim, Sang Jun Chun, Min Chul Cho, Juhyun Park, Chu Hong Park, Sung Yong Cho, Hyeon Jeong
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 3, p e0213586 (2019)
PLoS ONE, Vol 14, Iss 3, p e0213586 (2019)
We evaluated whether chronic administration of LIMK2-inhibitors could improve erectile function by alleviating CVOD through suppressing cavernosal fibrosis in a rat model of cavernosal nerve crush-injury (CNCI). Forty-two 12-week-old rats were equall
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 4, p e0187473 (2018)
PLoS ONE, Vol 13, Iss 4, p e0187473 (2018)
Pain is a sensory experience of a complex physiological nature in which is not only involved the nervous system. Among its many features is the development of chronic pain that is more complicated to treat because of the central somatization processe
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 9, p e0203782 (2018)
PLoS ONE, Vol 13, Iss 9, p e0203782 (2018)
Pathological synchronization in the basal ganglia network has been considered an important component of Parkinson's disease pathophysiology. An established treatment for some patients with Parkinson's disease is deep brain stimulation, in which a ton
Autor:
Kristen C. Hunn, Leigh M. Jacobs, Tally M. Largent-Milnes, Chelsea Jarvis, Nathan B. Arkwright, Thomas P. Davis, Margaret E. Tome, Charles P. Schaefer
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 2, p e0192340 (2018)
PLoS ONE, Vol 13, Iss 2, p e0192340 (2018)
The rates of opioid prescription and use have continued to increase over the last few decades resulting in a greater number of opioid tolerant patients. Treatment of acute pain from surgery and injury is a clinical challenge for these patients. Sever
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205372 (2018)
PLoS ONE
PLoS ONE
Development and maturation of submandibular salivary glands are influenced by intrauterine diabetic environment. Several studies investigated the effects of diabetes on the salivary glands. However, the effects of maternal diabetes on the submandibul
A fully automated image analysis method to quantify lung fibrosis in the bleomycin-induced rat model
Autor:
Shanon Seger, Anna K. Stalder, Oliver Nayler, Enrico Vezzali, Peter M.A. Groenen, Manuel Stritt, Patrick Hess
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193057 (2018)
PLoS ONE
PLoS ONE
Intratracheal administration of bleomycin induces fibrosis in the lung, which is mainly assessed by histopathological grading that is subjective. Current literature highlights the need of reproducible and quantitative pulmonary fibrosis analysis. If
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190039 (2018)
PLoS ONE
PLoS ONE
Burn-induced neuromuscular dysfunction may contribute to long-term morbidity; therefore, it is imperative to develop novel treatments. The present study investigated whether erythropoietin (EPO) administration attenuates burn-induced motor neuron apo
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191032 (2018)
PLoS ONE
PLoS ONE
Transient receptor potential vanilloid type 1 (TRPV1) is a polymodal receptor channel that responds to multiple types of stimuli, such as heat, acid, mechanical pressure and some vanilloids. Capsaicin is the most commonly used vanilloid to stimulate
Autor:
Martin F. Rath, Michael C. Kelly, Lynne A. Holtzclaw, Matthew W. Kelley, David C. Klein, Steven L. Coon, Joseph C. Mays
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205883 (2018)
Mays, J C, Kelly, M C, Coon, S L, Holtzclaw, L, Rath, M F, Kelley, M W & Klein, D C 2018, ' Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression ', PLOS ONE, vol. 13, no. 10, e0205883 . https://doi.org/10.1371/journal.pone.0205883
PLoS ONE
Mays, J C, Kelly, M C, Coon, S L, Holtzclaw, L, Rath, M F, Kelley, M W & Klein, D C 2018, ' Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression ', PLOS ONE, vol. 13, no. 10, e0205883 . https://doi.org/10.1371/journal.pone.0205883
PLoS ONE
The vertebrate pineal gland is dedicated to the production of the hormone melatonin, which increases at night to influence circadian and seasonal rhythms. This increase is associated with dramatic changes in the pineal transcriptome. Here, single-cel