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Publikováno v:
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258939 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258939 (2021)
Urethane, an acute laboratory anesthetic, produces distinct neurophysiological and physiological effects creating an effective model of the dynamics of natural sleep. As a model of both sleep-like neurophysiological activity and the downstream periph
Autor:
Maria do Socorro de Sousa Cartágenes, José Osvaldo Barbosa Neto, João Batista Santos Garcia, Lyvia Maria Rodrigues de Sousa Gomes, Rayanne Luiza Tajra Mualem Araújo, Nicolau Gregori Czeczko
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245194 (2021)
PLoS ONE
PLoS ONE
Pharmacological treatment of osteoarthritis is still inadequate due to the low efficacy of the drugs used. Dexmedetomidine via the intra-articular (i.a.) route might be an option for the treatment of osteoarthritis-associated pain. The present study
Autor:
S. Tiffany Donaldson, Antonio Alves, Corey Calhoun, Victoria Woytowicz, Briana Mason, Latifa Pina, Roshninder Kanda, Curtis Dunn
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0247707 (2021)
PLoS ONE, Vol 16, Iss 3, p e0247707 (2021)
Adolescent psychostimulant abuse has been on the rise over the past decade. This trend has demonstrable ramifications on adolescent behavior and brain morphology, increasing risk for development of addiction during adolescence and in later adulthood.
Autor:
Paola Marcolongo, Federica Pessina, Fabio Fusi, Maria Frosini, Elena Dreassi, Beatrice Gorelli, Valeria Francardi, Massimo Valoti, Paolo Fiorenzani, Daniela Giustarini, Maurizio Botta, Simona Saponara, Alessandra Gamberucci
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0233788 (2020)
PLoS ONE, Vol 15, Iss 5, p e0233788 (2020)
In pre-hypertension, moderate control of blood pressure (BP) can be obtained by a nutritional approach. The effects of a diet enriched with defatted larvae of the mealworm Tenebrio molitor (Coleoptera: Tenebrionidae) (TM) endowed with ACE inhibitory
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0226918 (2019)
PLoS ONE, Vol 14, Iss 12, p e0226918 (2019)
Recently, extensive efforts have been made to understand the importance of the extra-renal uric acid (UA) excretion pathways and their contribution to UA-related diseases. However, the method typically used to measure UA concentrations in the intesti
Autor:
Nastaren Abad, Alfred N. Fonteh, Xianghong Arakaki, Michael G. Harrington, Shiri Taron, David Lichtstein, Lorena Aparicio, Robert Cowan, Samuel C. Grant, Noah B. Gross
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0218041 (2019)
PLoS ONE, Vol 14, Iss 6, p e0218041 (2019)
There is strong evidence that neuronal hyper-excitability underlies migraine, and may or may not be preceded by cortical spreading depression. However, the mechanisms for cortical spreading depression and/or migraine are not established. Previous stu
Autor:
Jia Ning Foong, Abdullah Rasedee, Chaw Yee Beh, Jhi Biau Foo, Abdul Rahman Omar, Chee Wun How, Latifah Saiful Yazan, Gayathri Thevi Selvarajah
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219285 (2019)
PLoS ONE
PLoS ONE
Nanomedicine is an emerging area in the medical field, particularly in the treatment of cancers. Nanostructured lipid carrier (NLC) was shown to be a good nanoparticulated carrier for the delivery of tamoxifen (TAM). In this study, the tamoxifen-load
Autor:
Isadora Prado Cano, Carlos Ferreira dos Santos, Flavio Augusto Cardoso de Faria, Tânia Mary Cestari, Bella Luna Colombini-Ishikiriama, Adriana Maria Calvo, Walter L. Siqueira, Thiago José Dionísio
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217030 (2019)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE
Renin-angiotensin system (RAS) systemically or locally collaborates with tissue homeostasis, growth and development, which has been extensively studied for its pharmacological implications. This study was primarily aimed at finding and characterizing
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220473 (2019)
PLoS ONE
Absi, M, Eid, B G, Ashton, N, Hart, G & Gurney, A M 2019, ' Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels : Evidence for an endothelium-independent mechanism ', PLoS ONE, vol. 14, no. 8, e0220473 . https://doi.org/10.1371/journal.pone.0220473
PLoS ONE
Absi, M, Eid, B G, Ashton, N, Hart, G & Gurney, A M 2019, ' Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels : Evidence for an endothelium-independent mechanism ', PLoS ONE, vol. 14, no. 8, e0220473 . https://doi.org/10.1371/journal.pone.0220473
Simvastatin reduces pulmonary arterial pressure and right ventricular hypertrophy in animal models of pulmonary arterial hypertension (PAH) and is thought to restore endothelial dysfunction. In vivo effects of drugs are complicated by several factors
Autor:
Shanmugasundaram Natesan, Robert J. Christy, Jaideep Banerjee, Nicole L. Wrice, Shanmuganathan Seetharaman
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217965 (2019)
PLoS ONE
PLoS ONE
Infection control is necessary for improved burn wound regeneration. In this study contact burn wounds were induced on the dorsum of the rats and were infected with Pseudomonas aeruginosa (107cfu/ml of saline) and left overnight (12-14 hours) to esta