Zobrazeno 1 - 10
of 84
pro vyhledávání: ''
Autor:
Marco Andrey Cipriani Frade, Lúcia Helena Faccioli, Guilherme Ferreira Caetano, Claudia da Silva Bitencourt, Marcio Fronza, Irmgard Merfort, Francisco Wanderley Garcia Paula-Silva, Marcel Nani Leite, Thiago Antônio Moretti de Andrade
Publikováno v:
PLoS ONE
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE, Vol 9, Iss 11, p e112297 (2014)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE, Vol 9, Iss 11, p e112297 (2014)
Hyaluronidases are enzymes that degrade hyaluronan an important constituent of the extracellular matrix. They have been used as a spreading agent, improving the absorption of drugs and facilitating the subcutaneous infusion of fluids. Here, we invest
Autor:
Regina P. Markus, Daiane Gil Franco
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 9, p e106332 (2014)
PLoS ONE, Vol 9, Iss 9, p e106332 (2014)
The constitutive activation of nuclear factor-κB (NF-κB), a key transcription factor involved in neuroinflammation, is essential for the survival of neurons in situ and of cerebellar granule cells in culture. Melatonin is known to inhibit the activ
Autor:
Clara García-Mompó, Carmen Sandi, Juan Nacher, Stamatina Tzanoulinou, Vandana Veenit, Esther Castillo-Gómez
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e94666 (2014)
Plos One
PLoS ONE, Vol 9, Iss 4, p e94666 (2014)
Plos One
Stress during childhood and adolescence is a risk factor for psychopathology. Alterations in γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain, have been found following stress exposure and fear experiences and are often
Autor:
Pasquina Marzola, Marco Diana, Benedetta Mazzanti, Saturnino Spiga, Paola Quaranta, Biancamaria Longoni, Franco Mosca, Giovanna Mulas, Sara Antonini, M. Curcio
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e94783 (2014)
PLoS ONE, Vol 9, Iss 4, p e94783 (2014)
Graft vascularization is a crucial step to obtain stable normoglycemia in pancreatic islet transplantation. Endothelial progenitor cells (EPCs) contribute to neoangiogenesis and to the revascularization process during ischaemic events and play a key
Autor:
Wenyi Li, Ying Yang, Xiaoyan Zhang, Jun Xu, Jian Yang, Yujie Deng, Pengfei Lv, Hongli Zhang, Jian Huang
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e87254 (2014)
PLoS ONE, Vol 9, Iss 2, p e87254 (2014)
Autophagy is a conserved process in eukaryotes required for metabolism and is involved in diverse diseases. To investigate autophagy in skeletal muscle under hyperglycemia status, we established two hyperglycemia-rat models that differ in their circu
Autor:
Scott T. Lee, Matthew Ryals, Michael D. Nguyen, Ashley E. Ross, B. Jill Venton, Vishesh I. Choudhry
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87165 (2014)
PLoS ONE
PLoS ONE
Adenosine is a neuroprotective agent that inhibits neuronal activity and modulates neurotransmission. Previous research has shown adenosine gradually accumulates during pathologies such as stroke and regulates neurotransmission on the minute-to-hour
Autor:
Paige S. Davies, Elizabeth Droke, Alan J. Young, Gareth E. Davies, Yueshan Hu, Dustin Nowotny, Erik A. Ehli, Timothy J. Soundy
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93310 (2014)
PLoS ONE
PLoS ONE
Olanzapine is a first line medication for the treatment of schizophrenia, but it is also one of the atypical antipsychotics carrying the highest risk of weight gain. Metformin was reported to produce significant attenuation of antipsychotic-induced w
Autor:
Tien Chun Tsai, Wen Tai Chiu, Chun Wei Wu, Sheng Hsiang Lin, Ching Lin Tsai, Che Ming Lin, Jia Jin Jason Chen
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89293 (2014)
PLoS ONE
PLoS ONE
Dopaminergic PC12 cells can synthesize and release dopamine, providing a good cellular model for investigating dopamine regulation. Optogenetic stimulation of channelrhodopsin-2 provides high spatial and temporal precision for selective stimulation a
Autor:
Tianjian Liu, Jingxin Li, Ailin Xiao, Linlin Xu, Zhen Lei, Xiaoyu Li, Ning Yang, Junhan Zhao, Nannan Ning
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87627 (2014)
PLoS ONE
PLoS ONE
Chloroquine (CQ), a bitter tasting drug widely used in treatment of malaria, is associated gastrointestinal side effects including nausea or diarrhea. In the present study, we investigated the effect of CQ on electrolyte transport in rat ileum using
Autor:
Andries Kalsbeek, Roger A.H. Adan, José K. van den Heuvel, Eric Fliers, Leslie Eggels, Susanne E. la Fleur
Publikováno v:
PLoS ONE
PLoS ONE, 9(1). Public Library of Science
PLoS ONE, Vol 9, Iss 1, p e87729 (2014)
PLoS One, 9(1). Public Library of Science
PLoS ONE, 9(1). Public Library of Science
PLoS ONE, Vol 9, Iss 1, p e87729 (2014)
PLoS One, 9(1). Public Library of Science
ObjectiveLeptin resistance is a common hallmark of obesity. Rats on a free-choice high-fat high-sugar (fcHFHS) diet are resistant to peripherally administered leptin. The aim of this study was to investigate feeding responses to central leptin as wel