Zobrazeno 1 - 2
of 2
pro vyhledávání: '"David Lyden"'
Autor:
Kevin C. De Braganca, Jill M. Kolesar, Yasmin Khakoo, Tanya M. Trippett, Kim Kramer, Shakeel Modak, Stephen Gilheeney, Brian H. Kushner, Oren J. Becher, Jason T. Huse, Nai-Kong V. Cheung, David Lyden, Nathan E. Millard, Sofia Haque, Ira J. Dunkel, Ivan Spasojevic
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178593 (2017)
PLoS ONE
PLoS ONE
The PI3K/Akt/mTOR signaling pathway is aberrantly activated in various pediatric tumors. We conducted a phase I study of the Akt inhibitor perifosine in patients with recurrent/refractory pediatric CNS and solid tumors. This was a standard 3+3 open-l
Autor:
Hannah K. Lederman, Shahin Rafii, Rosandra N. Kaplan, Stefano Rivella, Stephen B. Doty, Dimitris Skokos, April S. Chan, Kristian Jensen, David Lyden
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7955 (2009)
PLoS ONE
PLoS ONE
Background The bone-bone marrow interface is an area of the bone marrow microenvironment in which both bone remodeling cells, osteoblasts and osteoclasts, and hematopoietic cells are anatomically juxtaposed. The close proximity of these cells natural