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Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0207750 (2018)
PLoS ONE, Vol 13, Iss 11, p e0207750 (2018)
N-(4-fluorophenyl)-N'-phenyl-N"-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine [ASP2905] is a potent and selective inhibitor of the potassium voltage-gated channel subfamily H member 3 (KCNH3) that was originally identified in our laboratory. K
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0207210 (2018)
PLoS ONE, Vol 13, Iss 11, p e0207210 (2018)
Type 2 diabetes (T2D) is a complex metabolic disease associated with alterations in glucose, lipid and protein metabolism. In order to characterize the biochemical phenotype of the Zucker diabetic fatty (ZDF) rat, the most common animal model for the
Autor:
Xin Zhao, Dengyun Xia, Jinge Yuan, Li Chu, Yongxue Chen, Yingying Zhang, Jun Li, Senming Zhao, Yanxin Cheng, Hong Li, Jianping Zhang, Ran Duan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 10, p e0203602 (2018)
PLoS ONE, Vol 13, Iss 10, p e0203602 (2018)
In order to determine the role of the adrenergic system in bupivacaine-induced cardiotoxicity, a series of experiments were performed. In an animal experiment, male Sprague-Dawley (SD) rats under chloral hydrate anesthesia received intravenous bupiva
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 10, p e0205869 (2018)
PLoS ONE, Vol 13, Iss 10, p e0205869 (2018)
For over a century, it has been speculated that the vestibular system transmits information about self-motion to the striatum. There have been inconsistent reports of such a connection, and interest in the subject has been increased by the experiment
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 10, p e0206152 (2018)
PLoS ONE, Vol 13, Iss 10, p e0206152 (2018)
Previous studies have shown that the CB1 receptor antagonist reverses steatohepatitis and its related features of metabolic syndrome, such as obesity and type 2 diabetes. However, the beneficial effects of CB1 receptor blockade on hepatic steatosis a
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 10, p e0206306 (2018)
PLoS ONE, Vol 13, Iss 10, p e0206306 (2018)
The aim of this study was done to determine whether dexamethasone treatment prevents posthemorrhagic hydrocephalus (PHH) development and attenuates brain damage after severe IVH in newborn rats. Severe IVH was induced by injecting; 100 μL of blood i
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 9, p e0205016 (2018)
PLoS ONE, Vol 13, Iss 9, p e0205016 (2018)
The dynorphin/kappa opioid receptor (DYN/KOR) system appears to be a key mediator of the behavioral effects of chronic exposure to alcohol. Although KOR opioid receptor antagonists have been shown to decrease stress-related behaviors in animal models
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202979 (2018)
The long-term use of proton pump inhibitors (PPIs) has been shown to increase the risk of cardiovascular mortality, however the molecular mechanisms are unknown. Superoxide has been implicated in the regulation of nerve growth factor (NGF), a mediato
Autor:
Gilles Gargala, Jean Jacques Ballet, Liqianhai Towledahong, Loïc Favennec, Jie Bai, Xin Liu, Arnaud François, Laetitia Le Goff, Phillipe Ducrotte
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2018, 13 (5), pp.e0198377. ⟨10.1371/journal.pone.0198377⟩
PLoS ONE, Vol 13, Iss 5, p e0198377 (2018)
PLoS ONE, 2018, 13 (5), pp.e0198377. ⟨10.1371/journal.pone.0198377⟩
PLoS ONE, Public Library of Science, 2018, 13 (5), pp.e0198377. ⟨10.1371/journal.pone.0198377⟩
PLoS ONE, Vol 13, Iss 5, p e0198377 (2018)
PLoS ONE, 2018, 13 (5), pp.e0198377. ⟨10.1371/journal.pone.0198377⟩
Somatostatins are proteins that are involved in gastrointestinal function. However, little is known with regard to somatostatin receptor subtype (SSTR) expression changes that occur in the jejunum during low-grade inflammation and during subsequent o
Autor:
Zsófia Spisák, András Czurkó, Gabriella Nyitrai, Dávid Gajári, Pálma Diószegi, Tamás Z. Kincses, Tamás Spisák
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0198265 (2018)
PLoS ONE, Vol 13, Iss 5, p e0198265 (2018)
Bilateral common carotid artery occlusion (BCCAo) in the rat is a widely used animal model of vascular dementia and a valuable tool for preclinical pharmacological drug testing, although the varying degrees of acute focal ischemic lesions it induces