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Autor:
Anjali Vivek, Jared Wahl, Todd W. Vanderah, Thomas P. Davis, Kathryn L. Kellohen, Seph M. Palomino, Vani Verkhovsky, Tally M. Largent-Milnes, Erika Liktor-Busa, Kiera T. Blawn, Beth M Wiese
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0227463 (2020)
PLoS ONE, Vol 15, Iss 5, p e0227463 (2020)
Disruption of blood-brain barrier integrity and dramatic failure of brain ion homeostasis including fluctuations of pH occurs during cortical spreading depression (CSD) events associated with several neurological disorders, including migraine with au
Autor:
Eva Pokorna, Libor Janousek, Tomáš Urban, František Duška, Petr Waldauf, V Dzupa, Adéla Krajčová, Milada Halačová, Kateřina Jiroutková
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 10, p e0217254 (2019)
PLoS ONE, Vol 14, Iss 10, p e0217254 (2019)
IntroductionPropofol causes a profound inhibition of fatty acid oxidation (FAO) and reduces spare electron transfer chain (ETC) capacity in a range of human and rodent cells and tissues – a feature that might be related to the pathogenesis of Propo
Publikováno v:
PLoS ONE
PLOS ONE
PLoS ONE, Vol 14, Iss 12, p e0225788 (2019)
PLOS ONE
PLoS ONE, Vol 14, Iss 12, p e0225788 (2019)
Melatonin has potential neuroprotective capabilities after neonatal hypoxia-ischemia (HI), but long-term effects have not been investigated. We hypothesized that melatonin treatment directly after HI could protect against early and delayed brain inju
Autor:
Nastaren Abad, Alfred N. Fonteh, Xianghong Arakaki, Michael G. Harrington, Shiri Taron, David Lichtstein, Lorena Aparicio, Robert Cowan, Samuel C. Grant, Noah B. Gross
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0218041 (2019)
PLoS ONE, Vol 14, Iss 6, p e0218041 (2019)
There is strong evidence that neuronal hyper-excitability underlies migraine, and may or may not be preceded by cortical spreading depression. However, the mechanisms for cortical spreading depression and/or migraine are not established. Previous stu
Autor:
Jia Ning Foong, Abdullah Rasedee, Chaw Yee Beh, Jhi Biau Foo, Abdul Rahman Omar, Chee Wun How, Latifah Saiful Yazan, Gayathri Thevi Selvarajah
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219285 (2019)
PLoS ONE
PLoS ONE
Nanomedicine is an emerging area in the medical field, particularly in the treatment of cancers. Nanostructured lipid carrier (NLC) was shown to be a good nanoparticulated carrier for the delivery of tamoxifen (TAM). In this study, the tamoxifen-load
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0238223 (2020)
PLoS ONE, Vol 15, Iss 8, p e0238223 (2020)
Being delivered as a low birthweight (LBW) infant is a risk factor for elevated blood pressure and future problems with cardiovascular and cerebellar diseases. Although premature babies are reported to have low numbers of nephrons, some unclear quest
Autor:
Shohreh Issazadeh-Navikas, Michal K. Oklinski, Tae-Hwan Kwon, Angelique Corthals, Robert Bockermann, Agnete Larsen, Søren Nielsen, Anne Skøttrup Mørkholt, John Nieland, Jette G. K. Nieland
Publikováno v:
Mørkholt, A S, Oklinski, M K, Larsen, A, Bockermann, R, Issazadeh-Navikas, S, Nieland, J G K, Kwon, T-H, Corthals, A, Nielsen, S & Nieland, J D V 2020, ' Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents ', PLoS ONE, vol. 15, no. 6, pp. e0234493 . https://doi.org/10.1371/journal.pone.0234493
PLoS ONE
Mørkholt, A S, Oklinski, M K, Larsen, A, Bockermann, R, Issazadeh-Navikas, S, Nieland, J G K, Kwon, T-H, Corthals, A, Nielsen, S & Nieland, J D V 2020, ' Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents ', PLOS ONE, vol. 15, no. 6, e0234493 . https://doi.org/10.1371/journal.pone.0234493
PLoS ONE, Vol 15, Iss 6, p e0234493 (2020)
Mørkholt, A S, Oklinski, M K, Larsen, A, Bockermann, R, Issazadeh-Navikas, S, Nieland, J G K, Kwon, T H, Corthals, A, Nielsen, S & Nieland, J D V 2020, ' Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents ', PLOS ONE, vol. 15, no. 6, e0234493 . https://doi.org/10.1371/journal.pone.0234493
PLoS ONE
Mørkholt, A S, Oklinski, M K, Larsen, A, Bockermann, R, Issazadeh-Navikas, S, Nieland, J G K, Kwon, T-H, Corthals, A, Nielsen, S & Nieland, J D V 2020, ' Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents ', PLOS ONE, vol. 15, no. 6, e0234493 . https://doi.org/10.1371/journal.pone.0234493
PLoS ONE, Vol 15, Iss 6, p e0234493 (2020)
Mørkholt, A S, Oklinski, M K, Larsen, A, Bockermann, R, Issazadeh-Navikas, S, Nieland, J G K, Kwon, T H, Corthals, A, Nielsen, S & Nieland, J D V 2020, ' Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents ', PLOS ONE, vol. 15, no. 6, e0234493 . https://doi.org/10.1371/journal.pone.0234493
Multiple sclerosis (MS) is a neurodegenerative disease characterized by demyelination and inflammation. Dysregulated lipid metabolism and mitochondrial dysfunction are hypothesized to play a key role in MS. Carnitine Palmitoyl Transferase 1 (CPT1) is
Autor:
Yong Fang Zhu, Zhi Wang, Danny Ma, Jesse Sidhu, Gireesh Seesankar, Ramesh Zacharias, Vikas Parihar, Natalie Zacal, Natalka Parzei, Katja Linher-Melville, Gurmit Singh, Manu Sharma, Ayesha Shahid
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234176 (2020)
PLoS ONE
PLoS ONE
Chronic neuropathic pain (NP) is a growing clinical problem for which effective treatments, aside from non-steroidal anti-inflammatory drugs and opioids, are lacking. Cannabinoids are emerging as potentially promising agents to manage neuroimmune eff
Autor:
Kristen C. Hunn, Leigh M. Jacobs, Tally M. Largent-Milnes, Chelsea Jarvis, Nathan B. Arkwright, Thomas P. Davis, Margaret E. Tome, Charles P. Schaefer
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 2, p e0192340 (2018)
PLoS ONE, Vol 13, Iss 2, p e0192340 (2018)
The rates of opioid prescription and use have continued to increase over the last few decades resulting in a greater number of opioid tolerant patients. Treatment of acute pain from surgery and injury is a clinical challenge for these patients. Sever
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205372 (2018)
PLoS ONE
PLoS ONE
Development and maturation of submandibular salivary glands are influenced by intrauterine diabetic environment. Several studies investigated the effects of diabetes on the salivary glands. However, the effects of maternal diabetes on the submandibul