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Autor:
Daniel R. Ambruso, Natalie J. Briones, Angelina F. Baroffio, John R. Murphy, Alexander D. Tran, Katherine Gowan, Bridget Sanford, Michael Ellison, Kenneth L. Jones
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN). The clinical use of IFN-γ has been driven by the finding that its administration to patie
Autor:
Guanghao Qin, Fang He, Hongda Zhang, Emmanuel Eric Pazo, Guangzheng Dai, Qingchi Yao, Wei He, Ling Xu, Tiezhu Lin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 2, p e0263587 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263587 (2022)
Aim To evaluate the association between the value of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to high-density lipoprotein ratio (MHR) and the development of retinal artery occlusion (RAO) and retinal vein occ
Autor:
Katie Bechman, Mark Yates, Kirsty Mann, Deepak Nagra, Laura-Jane Smith, Andy I. Rutherford, Amit Patel, Jimstan Periselneris, David Walder, Richard J. B. Dobson, Zeljko Kraljevic, James H. T. Teo, William Bernal, Richard Barker, James B. Galloway, Sam Norton
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0261142 (2022)
PLoS ONE, Vol 17, Iss 1, p e0261142 (2022)
Background The Covid-19 pandemic in the United Kingdom has seen two waves; the first starting in March 2020 and the second in late October 2020. It is not known whether outcomes for those admitted with severe Covid were different in the first and sec
Autor:
Parvin Kumar, Miranda Stiernborg, Anna Fogdell-Hahn, Kristoffer Månsson, Tomas Furmark, Daniel Berglind, Philippe A. Melas, Yvonne Forsell, Catharina Lavebratt
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0263173 (2022)
PLoS ONE
PLoS ONE
Mobility disability (MD) refers to substantial limitations in life activities that arise because of movement impairments. Although MD is most prevalent in older individuals, it can also affect younger adults. Increasing evidence suggests that inflamm
Autor:
Masanori A. Murayama, Erika Takada, Kenji Takai, Nagisa Arimitsu, Jun Shimizu, Tomoko Suzuki, Noboru Suzuki
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0260838 (2022)
PLoS ONE, Vol 17, Iss 1, p e0260838 (2022)
The immune checkpoint molecules such as PD-L1 and PD-L2 have a substantial contribution to cancer immunotherapy including breast cancer. Microarray expression profiling identified several molecular subtypes, namely luminal-type (with a good-prognosis
Autor:
Richard Wargodsky, Philip Dela Cruz, John LaFleur, David Yamane, Justin Sungmin Kim, Ivy Benjenk, Eric Heinz, Obinna Ome Irondi, Katherine Farrar, Ian Toma, Tristan Jordan, Jennifer Goldman, Timothy A. McCaffrey
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0261679 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE
Infection with the SARS-CoV2 virus can vary from asymptomatic, or flu-like with moderate disease, up to critically severe. Severe disease, termed COVID-19, involves acute respiratory deterioration that is frequently fatal. To understand the highly va
Autor:
Jurandir Tomaz de Miranda, Fabiana de Andrade Bringel, Ana Paula Pereira Velosa, Verônica Protocevich, Sandra de Morais Fernezlian, Pedro Leme Silva, Vera Luiza Capelozzi, Monica Beatriz Mathor, Walcy Rosolia Teodoro
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262532 (2022)
PLoS ONE
PLoS ONE
This study aimed to report the effects of different doses of ionizing radiation on inflammatory and repair stage of human skin graft adherence in Nude mice wounds. Animals were divided into transplanted with irradiated human skin grafts (IHSG) at 25
Autor:
Sophia Sarpong-Kumankomah, Katherine B. Knox, Michael E. Kelly, Gary Hunter, Bogdan Popescu, Helen Nichol, Karen Kopciuk, Henry Ntanda, Jürgen Gailer
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0262160 (2022)
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0262160 (2022)
Advanced analytical methods play an important role in quantifying serum disease biomarkers. The problem of separating thousands of proteins can be reduced by analyzing for a ‘sub-proteome’, such as the ‘metalloproteome’, defined as all protei
Autor:
Takuya Mori, Hiroaki Tanaka, Sota Deguchi, Yoshihito Yamakoshi, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Takahiro Toyokawa, Shigeru Lee, Kazuya Muguruma, Masaichi Ohira
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262455 (2022)
PLoS ONE
PLoS ONE
Nivolumab, an immune checkpoint blocker, has been approved for advanced gastric cancer (GC), but predictive factors of nivolumab’s efficacy in patients with GC, especially immune cells such as tissue-resident memory T cells or those forming tertiar
Autor:
Shoh Sasaki, Kensaku Nishihira, Atsushi Yamashita, Tomomi Fujii, Kenji Onoue, Yoshihiko Saito, Kinta Hatakeyama, Yoshisato Shibata, Yujiro Asada, Chiho Ohbayashi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0262413 (2022)
PLoS ONE, Vol 17, Iss 1, p e0262413 (2022)
Activation of the classical complement pathway plays a major role in regulating atherosclerosis progression, and it is believed to have both proatherogenic and atheroprotective effects. This study focused on C1q, the first protein in the classical pa