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Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262549 (2022)
PLoS ONE
PLoS ONE
Background Cytotoxic effects of radiation play an important role in the treatment of head and neck cancer. However, irradiation is known to lead to the migration of various cancer cells, including those of head and neck cancer. Recently, fibroblasts
Autor:
Yuya Fujita, Atsushi Kawakami, Haruki Matsumoto, Shuhei Yoshida, Jumpei Temmoku, Tomoyuki Asano, Shuzo Sato, Kohei Yokose, Eiji Suzuki, Toru Yago, Naoki Matsuoka, Makiko Yashiro-Furuya, Kiyoshi Migita, Hiroshi Watanabe
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0260254 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0260254 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
BackgroundRheumatoid arthritis (RA) is a heterogeneous inflammatory disease. Both anti-citrullinated peptide antibodies (ACPA) and inflammatory cytokines play an important role in the development of RA. The aim of this study was to investigate the as
Autor:
Kiyoko Takane, Yoko Hikiba, Chi Zhu, Yoichi Furukawa, Kiyoshi Yamaguchi, Makoto Hirata, Shin Maeda, Tsuneo Ikenoue, Xun Liu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257090 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257090 (2021)
Isocitrate dehydrogenase 1 and 2 (IDH1/2) mutations and their key effector 2-hydroxyglutarate (2-HG) have been reported to promote oncogenesis in various human cancers. To elucidate molecular mechanism(s) associated with IDH1/2 mutations, we establis
Publikováno v:
PLoS ONE, 16(8):e0253698. Public Library of Science
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0253698 (2021)
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0253698 (2021)
PLoS ONE, Vol 16, Iss 8 (2021)
Introduction Neutrophil extracellular traps (NETs) are DNA scaffolds enriched with antimicrobial proteins. NETs have been implicated in the development of various diseases, such as cardiovascular disease. Here, we investigate the association of demog
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE, Vol 16, Iss 8, p e0255639 (2021)
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE, Vol 16, Iss 8, p e0255639 (2021)
This study was aimed at exploring whether latent tuberculosis infection (LTBI) contributes to the pathogenesis of immune-mediated inflammatory diseases in a TB endemic setting. We screened 198 rheumatoid arthritis (RA) patients with tuberculin skin t
Autor:
Duangdao Wichadakul, Keerati Joyjamras, Nongyao Nonpanya, Pithi Chanvorachote, Kittipong Sanookpan, Boonchoo Sritularak, Chatchai Chaotham
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0254929 (2021)
PLoS ONE, Vol 16, Iss 8, p e0254929 (2021)
In searching for novel targeted therapeutic agents for lung cancer treatment, norcycloartocarpin from Artocarpus gomezianus was reported in this study to promisingly interacted with Akt and exerted the apoptosis induction and epithelial-to-mesenchyma
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254783 (2021)
PLoS ONE, Vol 16, Iss 7, p e0254783 (2021)
An array of isoforms of the nuclear estrogen receptor alpha (ER-α) protein contribute to heterogeneous response in breast cancer (BCa); yet, a single-cell analysis tool that distinguishes the full-length ER-α66 protein from the activation function-
Autor:
Frédéric de Blay, Virginie Doyen, Olivier Michel, Hiep Tran Thi Mong, Thanh Le Chi, Phuong Thi Ngoe Huynh, Francis Corazza, Hoa Nhu Thi, Carine Truyens
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0253887 (2021)
PLoS ONE, Vol 16, Iss 7, p e0253887 (2021)
Background IgE characterizes the humoral response of allergic sensitization but less is known about what modulates its function and why some patients present clinical symptoms for a given IgE level and others do not. An IgE response also occurs durin
Autor:
Hal E. Broxmeyer, Elizabeth A. Williamson, Sarah C. Glover, Austin Kirby, Yilianys Pride, Maegan L. Capitano, Aruna S. Jaiswal, Gayathri Srinivasan, Daniel D Mais, Robert Hromas, Fatemah G. Amlashi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0252805 (2021)
PLoS ONE, Vol 16, Iss 7, p e0252805 (2021)
Chemokines are small proteins that promote leukocyte migration during development, infection, and inflammation. We and others isolated the unique chemokine CCL21, a potent chemo-attractant for naïve T-cells, naïve B-cells, and immature dendritic ce
Autor:
Antônio Lacerda Filho, André Lopes Saraiva, Rodrigo Rodrigues Franco, Allisson Benatti Justino, Maria de Fátima Leite, Andressa França, Rodrigo M. Florentino, Foued Salmen Espindola, Matheus de Castro Fonseca
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0250394 (2021)
PLoS ONE, Vol 16, Iss 7, p e0250394 (2021)
Plant species from Annonaceae are commonly used in traditional medicine to treat various cancer types. This study aimed to investigate the antiproliferative potential of an alkaloid and acetogenin-rich fraction from the fruit peel of Annona crassiflo