Zobrazeno 1 - 10
of 1 374
pro vyhledávání: ''
Autor:
Kiyoko Takane, Yoko Hikiba, Chi Zhu, Yoichi Furukawa, Kiyoshi Yamaguchi, Makoto Hirata, Shin Maeda, Tsuneo Ikenoue, Xun Liu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257090 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257090 (2021)
Isocitrate dehydrogenase 1 and 2 (IDH1/2) mutations and their key effector 2-hydroxyglutarate (2-HG) have been reported to promote oncogenesis in various human cancers. To elucidate molecular mechanism(s) associated with IDH1/2 mutations, we establis
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254783 (2021)
PLoS ONE, Vol 16, Iss 7, p e0254783 (2021)
An array of isoforms of the nuclear estrogen receptor alpha (ER-α) protein contribute to heterogeneous response in breast cancer (BCa); yet, a single-cell analysis tool that distinguishes the full-length ER-α66 protein from the activation function-
Autor:
Hal E. Broxmeyer, Elizabeth A. Williamson, Sarah C. Glover, Austin Kirby, Yilianys Pride, Maegan L. Capitano, Aruna S. Jaiswal, Gayathri Srinivasan, Daniel D Mais, Robert Hromas, Fatemah G. Amlashi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0252805 (2021)
PLoS ONE, Vol 16, Iss 7, p e0252805 (2021)
Chemokines are small proteins that promote leukocyte migration during development, infection, and inflammation. We and others isolated the unique chemokine CCL21, a potent chemo-attractant for naïve T-cells, naïve B-cells, and immature dendritic ce
Autor:
Antônio Lacerda Filho, André Lopes Saraiva, Rodrigo Rodrigues Franco, Allisson Benatti Justino, Maria de Fátima Leite, Andressa França, Rodrigo M. Florentino, Foued Salmen Espindola, Matheus de Castro Fonseca
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0250394 (2021)
PLoS ONE, Vol 16, Iss 7, p e0250394 (2021)
Plant species from Annonaceae are commonly used in traditional medicine to treat various cancer types. This study aimed to investigate the antiproliferative potential of an alkaloid and acetogenin-rich fraction from the fruit peel of Annona crassiflo
Autor:
Ki Eun Maeng, Lauren Greenberg, Madhusudana N. Shampur, Jun-Young Lee, Richard Franka, Cheol Min Kim, Modupe O. V. Osinubi, Sun Ju Keum, Soo Young Lee, Ji Min Seo, Hyunjoo Lee, Jung Sun Ahn, Kye Sook Yi, Minsoo Kim, Ji-Young Shin, Pan Kyeom Kim, Min Joo Choo, Charles E. Rupprecht
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0256779 (2021)
PLoS ONE, Vol 16, Iss 9, p e0256779 (2021)
Post-exposure prophylaxis (PEP) is highly effective in preventing disease progression of rabies when used in timely and appropriate manner. The key treatment for PEP is infiltration of rabies immune globulin (RIG) into lesion site after bite exposure
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254853 (2021)
PLoS ONE, Vol 16, Iss 7, p e0254853 (2021)
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the western world. In previous studies, various proportion of patients was found to carry CD11b+ or CD11c+ B cells whose presence was an unfavourable prognostic factor. The exact mec
Autor:
N. Max Schabla, Patrick C. Swanson
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258683 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258683 (2021)
The development of B and T lymphocytes critically depends on RAG1/2 endonuclease activity to mediate antigen receptor gene assembly by V(D)J recombination. Although control of RAG1/2 activity through cell cycle- and ubiquitin-dependent degradation of
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0252118 (2021)
PLoS ONE, Vol 16, Iss 5, p e0252118 (2021)
Reactive microglia are suggested to be involved in neurological disorders, and the mechanisms underlying microglial activity may provide insights into therapeutic strategies for neurological diseases. Microglia produce immunological responses to vari
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0250805 (2021)
PLoS ONE, Vol 16, Iss 5, p e0250805 (2021)
A FLAG tag consisting of DYKDDDDK is an epitope tag that is frequently and widely used to detect recombinant proteins of interest. In this study, we performed a CRISPR-based genetic screening to identify factors involved in the detection of a FLAG-ta
Autor:
E Savchenko, A. V. Revishchin, D Shamadykova, Ekaterina Yu. Rybalkina, Galina Pavlova, Nadezhda N. Kust, Dmitry Y. Panteleev
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258289 (2021)
PLoS ONE
PLoS ONE
The glial cell line‐derived neurotrophic factor (GDNF) is involved in the survival of dopaminergic neurons. Besides, GDNF can also induce axonal growth and creation of new functional synapses. GDNF potential is promising for translation to treat di