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Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0246019 (2021)
PLoS ONE
PLoS ONE
With population growth and aging, more and more patients with cerebral infarction have varying degrees of disability. ATP-sensitive potassium (KATP) channels regulate many cellular functions by coupling metabolic status with cell membrane electrical
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0247890 (2021)
PLoS ONE
PLoS ONE
Objective This study aimed to monitor the secretion of serotonin and melatonin in the blood serum of rats in the presence of rice bran (RB), and Sarcodon aspratus (S) extracts for sleep promotion. Background Sleep is a natural physiological phenomeno
Autor:
Nicola Beltraminelli, Paul R. Pentel, Amy Saykao, Thomas Thisted, Zuzanna Biesova, Stéphanie Fallot, Stephen Horrigan, Steve Fuller, Darryl Sampey, Bin Zhou, Michael D. Raleigh, Matthew W. Kalnik, Mark G. LeSage
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254247 (2021)
PLoS ONE
PLoS ONE
Use of nicotine-specific monoclonal antibodies (mAbs) to sequester and reduce nicotine distribution to brain has been proposed as a therapeutic approach to treat nicotine addiction (the basis of tobacco use disorder). A series of monoclonal antibodie
Autor:
Nashwa W. Yassa, Doaa A. Ghareeb, Sofia Khalil, Samar R. Saleh, Maha A. El Demellawy, Mohamed M. El-Sayed
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0237929 (2020)
PLoS ONE, Vol 15, Iss 8, p e0237929 (2020)
BackgroundNeuroinflammation causes neurodegenerative conditions like Alzheimer's disease (AD). Ipriflavone (IP), therapeutic compound to postmenopausal osteoporosis, has limited estrogenic activity and is accounted as AChE inhibitor. The developing o
Autor:
Victor E. Arana-Chavez, Alyne Simões, Cíntia Yuki Fukuoka, Hugo Passos Vicari, Ujjal K. Bhawal, Carla Renata Sipert, Yoshimitsu Abiko
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0236727 (2020)
PLoS ONE, Vol 15, Iss 8, p e0236727 (2020)
Low-power laser irradiation (LPLI) is clinically used to modulate inflammation, proliferation and apoptosis. However, its molecular mechanisms are still not fully understood. This study aimed to describe the effects of LPLI upon inflammatory, apoptot
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0232413 (2020)
PLoS ONE, Vol 15, Iss 5, p e0232413 (2020)
Background Acute myocardial infarction (AMI) remains the most common cause of morbidity and mortality worldwide. The present study was directed to investigate the beneficial effects of benfotiamine pre- and post-treatments in isoproterenol (ISO)-indu
Autor:
Toshio Mochizuki, Tomochika Maoka, Seiji Hashimoto, Takao Koike, Tetsuya Kawata, Takashi Shigematsu
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0242332 (2020)
PLoS ONE
PLoS ONE
We have reported previously that renal hemodynamic abnormalities exist in the prediabetic stage of type II diabetic rats. At this prediabetic stage these rats have hyperinsulinemia, insulin resistance and metabolic syndrome. It is well known that ins
Autor:
Jamil Awad Shibli, Geysica Kauane dos Reis Ribeiro, Josuel Siqueira Azarias, Tamires Szemereske Miranda, Marta Ferreira Bastos, Roberto Puertas Garcia, Fernando de Souza Malta
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237660 (2020)
PLoS ONE
PLoS ONE
This study evaluated the influence of type 2 diabetes mellitus on bone loss, bone repair and cytokine production in hyperglycemic rats, treated or not with metformin. The animals were distributed as follow: Non-Hyperglycemic (NH), Non Hyperglycemic w
Autor:
Kristina Cechova, Petr Svoboda, Hana Ujcikova, Miroslava Vosahlikova, Michal Jágr, Lenka Roubalova
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231721 (2020)
PLoS ONE
PLoS ONE
Opioid addiction is recognized as a chronic relapsing brain disease resulting from repeated exposure to opioid drugs. Cellular and molecular mechanisms underlying the ability of organism to return back to the physiological norm after cessation of dru
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0226918 (2019)
PLoS ONE, Vol 14, Iss 12, p e0226918 (2019)
Recently, extensive efforts have been made to understand the importance of the extra-renal uric acid (UA) excretion pathways and their contribution to UA-related diseases. However, the method typically used to measure UA concentrations in the intesti