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Autor:
Byung Kook Lee, Najmiddin Mamadjonov, Chun Song Youn, In Seok Jeong, Yong Il Min, Hyoung Youn Lee, Tag Heo, Yong Hun Jung, Kyung Woon Jeung
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0249794 (2021)
PLoS ONE, Vol 16, Iss 4, p e0249794 (2021)
Several studies have suggested that sympathetic overstimulation causes deleterious effects in septic shock. A previous study suggested that pralidoxime exerted a pressor effect through a mechanism unrelated to the sympathetic nervous system; this eff
Autor:
Jirawan Thongbunchoo, Ketsaraporn Nammultriputtar, Jarinthorn Teerapornpuntakit, Kornkamon Lertsuwan, Narattaphol Charoenphandhu, Natnicha Tannop, Supanan Nanthawuttiphan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0234009 (2020)
PLoS ONE, Vol 15, Iss 5, p e0234009 (2020)
One of the potential contributing factors for iron overload-induced osteoporosis is the iron toxicity on bone forming cells, osteoblasts. In this study, the comparative effects of Fe3+ and Fe2+ on osteoblast differentiation and mineralization were st
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0230238 (2020)
PLoS ONE, Vol 15, Iss 3, p e0230238 (2020)
Social withdrawal in the sub-chronic phencyclidine (PCP) rat model, a behavioral correlate of the negative symptoms of schizophrenia, results from deficits in brain endocannabinoid transmission. As cannabis intake has been shown to affect negatively
Autor:
Kyung-Hyun Kim, Geum-Lan Hong, Da-Young Jung, Shanika Karunasagara, Ju-Young Jung, Kyoungwon Cho
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0236879 (2020)
PLoS ONE
PLoS ONE
Benign prostatic hyperplasia (BPH) is a progressive pathological condition associated with proliferation of prostatic tissues, prostate enlargement, and lower-urinary tract symptoms. However, the mechanism underlying the pathogenesis of BPH is unclea
Autor:
Yves Henrotin, Sonia Escaich, Sébastien Pirson, Carelli Claude, R. Montjean, Raffaello Paolini, Thibaut Neutelings, Vetu Christelle
Publikováno v:
PLoS ONE
PLOS ONE
PLoS ONE, Vol 15, Iss 4, p e0231240 (2020)
PLOS ONE
PLoS ONE, Vol 15, Iss 4, p e0231240 (2020)
Objective REG-O3 is a 24-aminoacid chimeric peptide combining a sequence derived from growth hormone (GH) and an analog of somatostatin (SST), molecules displaying cartilage repair and anti-inflammatory properties, respectively. This study aimed to i
Autor:
Eva Pokorna, Libor Janousek, Tomáš Urban, František Duška, Petr Waldauf, V Dzupa, Adéla Krajčová, Milada Halačová, Kateřina Jiroutková
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 10, p e0217254 (2019)
PLoS ONE, Vol 14, Iss 10, p e0217254 (2019)
IntroductionPropofol causes a profound inhibition of fatty acid oxidation (FAO) and reduces spare electron transfer chain (ETC) capacity in a range of human and rodent cells and tissues – a feature that might be related to the pathogenesis of Propo
Autor:
Lin Zhao, Wei Wang, Xin-Xin Yang, Yunkun Zhang, Xian-Sheng Meng, Yong-Rui Bao, Li Tianjiao, Wang Shuai
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248700 (2021)
PLoS ONE
PLoS ONE
As a traditional Chinese medicine (TCM) with a usage history of over 2,000 years in China, Spica Schizonepetae possesses definite clinical activity in the treatment of non-small cell lung cancer (NSCLC). However, its active ingredients and mechanism
Publikováno v:
PLoS ONE
PLOS ONE
PLoS ONE, Vol 14, Iss 12, p e0225788 (2019)
PLOS ONE
PLoS ONE, Vol 14, Iss 12, p e0225788 (2019)
Melatonin has potential neuroprotective capabilities after neonatal hypoxia-ischemia (HI), but long-term effects have not been investigated. We hypothesized that melatonin treatment directly after HI could protect against early and delayed brain inju
Autor:
Yuliia Holota, Natalia Dzyubenko, Liudmyla Ostapchenko, Izumi Kaji, I. Vareniuk, Tetiana Serhiychuk, Liudmyla Zakordonets, Viktoria Stetska, Ganna Tolstanova, Taisa Dovbynchuk, Tetiana Chervinska
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 8, p e0220642 (2019)
PLoS ONE, Vol 14, Iss 8, p e0220642 (2019)
Epidemiological studies revealed that antibiotics exposure increases a risk of inflammatory bowel diseases (IBD) development. It remained largely unknown how antibiotic-induced dysbiosis confers the risk for enhanced inflammatory response. The aim of
Autor:
Jia Ning Foong, Abdullah Rasedee, Chaw Yee Beh, Jhi Biau Foo, Abdul Rahman Omar, Chee Wun How, Latifah Saiful Yazan, Gayathri Thevi Selvarajah
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219285 (2019)
PLoS ONE
PLoS ONE
Nanomedicine is an emerging area in the medical field, particularly in the treatment of cancers. Nanostructured lipid carrier (NLC) was shown to be a good nanoparticulated carrier for the delivery of tamoxifen (TAM). In this study, the tamoxifen-load