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Publikováno v:
PLoS ONE
Dysregulation of calcium homeostasis has been hypothesized to play a role in Alzheimer’s disease (AD) pathogenesis. Increased calcium levels can impair axonal transport, disrupt synaptic transmission, and ultimately lead to cell death. Given the po
Autor:
Yung-Cheng Huang, Shu-Meng Hsu, Feng-Shiun Shie, Young-Ji Shiao, Li-Jung Chao, Hui-Wen Chen, Heng-Hsiang Yao, Meng An Chien, Chung-Chih Lin, Huey-Jen Tsay
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0260966 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE
Diabetes is a risk factor for Alzheimer’s disease (AD), a chronic neurodegenerative disease. We and others have shown prediabetes, including hyperglycemia and obesity induced by high fat and high sucrose diets, is associated with exacerbated amyloi
Autor:
Jurandir Tomaz de Miranda, Fabiana de Andrade Bringel, Ana Paula Pereira Velosa, Verônica Protocevich, Sandra de Morais Fernezlian, Pedro Leme Silva, Vera Luiza Capelozzi, Monica Beatriz Mathor, Walcy Rosolia Teodoro
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262532 (2022)
PLoS ONE
PLoS ONE
This study aimed to report the effects of different doses of ionizing radiation on inflammatory and repair stage of human skin graft adherence in Nude mice wounds. Animals were divided into transplanted with irradiated human skin grafts (IHSG) at 25
Autor:
Sophia Sarpong-Kumankomah, Katherine B. Knox, Michael E. Kelly, Gary Hunter, Bogdan Popescu, Helen Nichol, Karen Kopciuk, Henry Ntanda, Jürgen Gailer
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0262160 (2022)
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0262160 (2022)
Advanced analytical methods play an important role in quantifying serum disease biomarkers. The problem of separating thousands of proteins can be reduced by analyzing for a ‘sub-proteome’, such as the ‘metalloproteome’, defined as all protei
Autor:
Jamie-Lee M. Thompson, Daniel W. D. West, Thomas M. Doering, Boris P. Budiono, Sarah J. Lessard, Lauren G. Koch, Steven L. Britton, Nuala M. Byrne, Matthew A. Brown, Kevin J. Ashton, Vernon G. Coffey
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0261723 (2022)
PLoS ONE, Vol 17, Iss 1, p e0261723 (2022)
Skeletal muscle atrophy is a physiological response to disuse, aging, and disease. We compared changes in muscle mass and the transcriptome profile after short-term immobilization in a divergent model of high and low responders to endurance training
Autor:
Tomoka Igata, Hiroshi Tanaka, Kan Etoh, Seonghyeon Hong, Naoki Tani, Tomoaki Koga, Mitsuyoshi Nakao
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262488 (2022)
PLoS ONE
PLoS ONE
Cellular senescence is accompanied by metabolic and epigenomic remodeling, but the transcriptional mechanism of this process is unclear. Our previous RNA interference-based screen of chromatin factors found that lysine methyltransferases including SE
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0262223 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE, Vol 17, Iss 1, p e0262223 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)
Contact lens usage has contributed to increased incidence rates of Acanthamoeba keratitis (AK), a serious corneal infection that can lead to blindness. Since symptoms associated with AK closely resemble those incurred by bacterial or fungal keratitis
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0255860 (2021)
PLoS ONE, Vol 16, Iss 11, p e0255860 (2021)
The molecular mechanisms underlying morphological diversity in retinal cell types are poorly understood. We have previously reported that several members of the Copine family of Ca-dependent membrane adaptors are expressed in Retinal Ganglion Cells a
Autor:
Ann-Kathrin Vlacil, Sebastian Bänfer, Ralf Jacob, Nicole Trippel, Istemi Kuzu, Bernhard Schieffer, Karsten Grote
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0260181 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0260181 (2021)
Due to its increasing production, durability and multiple applications, plastic is a material we encounter every day. Small plastic particles from the μm to the mm range are classified as microplastics and produced for cosmetic and medical products,
Autor:
Hong Ki Min, JeongWon Choi, Seon-Yeong Lee, A. Ram Lee, Byung-Moo Min, Mi-La Cho, Sung-Hwan Park
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE, Vol 17, Iss 1, p e0262183 (2022)
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0262183 (2022)
PLoS ONE
Purpose Spondyloarthritis (SpA) is a systemic inflammatory arthritis mediated mainly by interleukin (IL)-17. The vitronectin-derived bioactive peptide, VnP-16, exerts an anti-osteoporotic effect via β1 and αvβ3 integrin signaling. SpA is associate