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Autor:
Yung-Cheng Huang, Shu-Meng Hsu, Feng-Shiun Shie, Young-Ji Shiao, Li-Jung Chao, Hui-Wen Chen, Heng-Hsiang Yao, Meng An Chien, Chung-Chih Lin, Huey-Jen Tsay
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0260966 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE
Diabetes is a risk factor for Alzheimer’s disease (AD), a chronic neurodegenerative disease. We and others have shown prediabetes, including hyperglycemia and obesity induced by high fat and high sucrose diets, is associated with exacerbated amyloi
Autor:
Jamie-Lee M. Thompson, Daniel W. D. West, Thomas M. Doering, Boris P. Budiono, Sarah J. Lessard, Lauren G. Koch, Steven L. Britton, Nuala M. Byrne, Matthew A. Brown, Kevin J. Ashton, Vernon G. Coffey
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0261723 (2022)
PLoS ONE, Vol 17, Iss 1, p e0261723 (2022)
Skeletal muscle atrophy is a physiological response to disuse, aging, and disease. We compared changes in muscle mass and the transcriptome profile after short-term immobilization in a divergent model of high and low responders to endurance training
Autor:
Demiana H. Hanna, Gamal R. Saad
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258115 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258115 (2021)
Purpose This study aims to prepare folic acid coated tin oxide nanoparticles (FA-SnO2 NPs) for specifically targeting human ovarian cancer cells with minimum side effects against normal cells. Methods The prepared FA-SnO2 NPs were characterized by FT
Autor:
Heba M. I. Abdallah, Sally A. El Awdan, Rehab F. Abdel-Rahman, Abdel Razik H. Farrag, Rasha M. Allam
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0258998 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE, Vol 17, Iss 1, p e0258998 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)
Hepatocellular carcinoma (HCC) is one of the most burdened tumors worldwide, with a complex and multifactorial pathogenesis. Current treatment approaches involve different molecular targets. Phytochemicals have shown considerable promise in the preve
Autor:
Naama E. Toledano Furman, Cecilia Martin, Karthik S. Prabhakara, Henry W. Caplan, Soheil Zorofchian, Charles S. Cox, Scott D. Olson, Hasen Xue
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251601 (2021)
PLoS ONE, Vol 16, Iss 5, p e0251601 (2021)
Traumatic brain injury (TBI) causes both physical disruption of the blood brain barrier (BBB) and altered immune responses that can lead to significant secondary brain injury and chronic inflammation within the central nervous system (CNS). Cell ther
Autor:
Etsuro Ito, Taka Nakahara, Tohru Yoshioka, Kohji Hotta, Yutaka Shindo, Mai Mochizuki, Yuki Arimura, Kotaro Oka, Ryu Yamanaka
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251356 (2021)
PLoS ONE, Vol 16, Iss 5, p e0251356 (2021)
Elucidating the mechanisms underlying human pain sensation requires the establishment of an in vitro model of pain reception comprising human cells expressing pain-sensing receptors and function properly as neurons. Human dental pulp stem cells (hDPS
Autor:
Neel K. Krishna, Alice L. Werner, Kaitlyn G. Jackson, Adrianne I. Enos, Marshall J. Glesby, Magdielis Gregory Rivera, Pamela S. Hair, Turaj Vazifedan, Brittany P. Lassiter, Alana C. Sampson, Frank A. Lattanzio, Kenji M. Cunnion
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0259133 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)
Acute lung injury (ALI) often causes severe trauma that may progress to significant morbidity and mortality. ALI results from a combination of the underlying clinical condition of the patient (e.g., inflammation) with a secondary insult such as viral
Autor:
E Savchenko, A. V. Revishchin, D Shamadykova, Ekaterina Yu. Rybalkina, Galina Pavlova, Nadezhda N. Kust, Dmitry Y. Panteleev
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258289 (2021)
PLoS ONE
PLoS ONE
The glial cell line‐derived neurotrophic factor (GDNF) is involved in the survival of dopaminergic neurons. Besides, GDNF can also induce axonal growth and creation of new functional synapses. GDNF potential is promising for translation to treat di
Autor:
Muhammad Manko, John Idoko, Kasimu Umar Adoke, Adamu Abdullahi, Abdullahi Mohammed, Surajo Mohammed Aminu, Sani Abubakar, Sani Ibrahim, Yawale Iliyasu, Halimatu Sadiya Musa, Khalid Zahir Shah, Ahmed Adamu, Aishatu Maude Suleiman, Mohammed Faruk, Abdulmumini Hassan Rafindadi, Cheh Agustin Awasum, Rakiya Saidu, Abdullahi Jibril Randawa, Atara Ntekim
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245581 (2021)
PLoS ONE
BASE-Bielefeld Academic Search Engine
PLoS ONE
BASE-Bielefeld Academic Search Engine
Evasion of apoptosis is associated with treatment resistance and metastasis in colorectal cancer (CRC). Various cellular processes are associated with evasion of apoptosis. These include overexpression of pro-apoptotic proteins (including p53 and PD-
Autor:
Ashok Prabhu, Judith Huettemeister, Leif-Hendrik Boldt, Sandra C. Klaucke, Frank R. Heinzel, Philipp Lacour, Florian Blaschke, Abdul Shokor Parwani, Lars Bullinger, Sanzio Dimai, Harald Stachelscheid, Felix Hohendanner, Jan Kruse, Burkert Pieske, Lukas Semmler
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255976 (2021)
PLoS ONE
PLoS ONE
Background Cardiac injury associated with cytokine release frequently occurs in SARS-CoV-2 mediated coronavirus disease (COVID19) and mortality is particularly high in these patients. The mechanistic role of the COVID19 associated cytokine-storm for