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Autor:
Jamie-Lee M. Thompson, Daniel W. D. West, Thomas M. Doering, Boris P. Budiono, Sarah J. Lessard, Lauren G. Koch, Steven L. Britton, Nuala M. Byrne, Matthew A. Brown, Kevin J. Ashton, Vernon G. Coffey
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0261723 (2022)
PLoS ONE, Vol 17, Iss 1, p e0261723 (2022)
Skeletal muscle atrophy is a physiological response to disuse, aging, and disease. We compared changes in muscle mass and the transcriptome profile after short-term immobilization in a divergent model of high and low responders to endurance training
Autor:
Tomoka Igata, Hiroshi Tanaka, Kan Etoh, Seonghyeon Hong, Naoki Tani, Tomoaki Koga, Mitsuyoshi Nakao
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262488 (2022)
PLoS ONE
PLoS ONE
Cellular senescence is accompanied by metabolic and epigenomic remodeling, but the transcriptional mechanism of this process is unclear. Our previous RNA interference-based screen of chromatin factors found that lysine methyltransferases including SE
Autor:
Demiana H. Hanna, Gamal R. Saad
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258115 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258115 (2021)
Purpose This study aims to prepare folic acid coated tin oxide nanoparticles (FA-SnO2 NPs) for specifically targeting human ovarian cancer cells with minimum side effects against normal cells. Methods The prepared FA-SnO2 NPs were characterized by FT
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258157 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258157 (2021)
Eimeria parasites cause enteric disease in livestock and the closely related Cyclospora cayetanensis causes human disease. Oocysts of these coccidian parasites undergo maturation (sporulation) before becoming infectious. Here, we assessed transcripti
Autor:
Kiyoko Takane, Yoko Hikiba, Chi Zhu, Yoichi Furukawa, Kiyoshi Yamaguchi, Makoto Hirata, Shin Maeda, Tsuneo Ikenoue, Xun Liu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257090 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257090 (2021)
Isocitrate dehydrogenase 1 and 2 (IDH1/2) mutations and their key effector 2-hydroxyglutarate (2-HG) have been reported to promote oncogenesis in various human cancers. To elucidate molecular mechanism(s) associated with IDH1/2 mutations, we establis
Autor:
Christel Rousseaux, Paolo Spagnolo, Silvia Speca, Caroline Dubuquoy, Pierre Desreumaux, Philippe Chavatte
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257281 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257281 (2021)
The development of more effective, better tolerated drug treatments for progressive pulmonary fibrosis (of which idiopathic pulmonary fibrosis is the most common and severe form) is a research priority. The peroxisome proliferator-activated receptor
Autor:
Xavier Manière, Nicole C. McKnight, Patricia Richard, Lucie Kozlowski, Hélène Guillorit, Patrice Garnier, Antoine Danchin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE, Vol 16, Iss 8, p e0253216 (2021)
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE, Vol 16, Iss 8, p e0253216 (2021)
Growing evidence suggests that human gut bacteria, which comprise the microbiome, are linked to several neurodegenerative disorders. An imbalance in the bacterial population in the gut of Parkinson’s disease (PD) and Alzheimer’s disease (AD) pati
Autor:
Hirohisa Kusuhara, Noritaka Isogai, Takeshi Teramura, William J. Landis, Shinichi Asamura, Ananth S. Murthy, Yu Sueyoshi, Narihiko Hirano, Robin Jacquet
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0253149 (2021)
PLoS ONE, Vol 16, Iss 7, p e0253149 (2021)
A major obstacle for tissue engineering ear-shaped cartilage is poorly developed tissue comprising cell-scaffold constructs. To address this issue, bioresorbable scaffolds of poly-ε-caprolactone (PCL) and polyglycolic acid nanofibers (nanoPGA) were
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0260252 (2021)
PLoS ONE, Vol 16, Iss 11, p e0260252 (2021)
High grade glioma is one of the deadliest human cancers with a median survival rate of only one year following diagnosis. The highly motile and invasive nature of high grade glioma makes it difficult to completely remove surgically. Therefore, increa
Autor:
Nadezda V. Volkova, Simone Bertolini, Anton Gartner, Peter J. Campbell, Moritz Gerstung, Bin Wang, Víctor González-Huici, Bettina Meier
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258269 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258269 (2021)
Ionizing radiation (IR) is widely used in cancer therapy and accidental or environmental exposure is a major concern. However, little is known about the genome-wide effects IR exerts on germ cells and the relative contribution of DNA repair pathways