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pro vyhledávání: ''
Autor:
Abdel-wahab A. Alsenosy, Kadry M. Sadek, Shaker A. Mousa, Ahmed Sayed-Ahmed, Safinaz A. Ibrahim, Mustafa S. Atta, Ali H. El-Far, Soad K. Al Jaouni
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222410 (2019)
PLoS ONE
PLoS ONE
Oxidative stresses intensify the progression of diabetes-related behavioural changes and testicular injuries. Graviola (Annona muricata), a small tree of the Annonaceae family, has been investigated for its protective effects against diabetic complic
Autor:
Shohreh Issazadeh-Navikas, Michal K. Oklinski, Tae-Hwan Kwon, Angelique Corthals, Robert Bockermann, Agnete Larsen, Søren Nielsen, Anne Skøttrup Mørkholt, John Nieland, Jette G. K. Nieland
Publikováno v:
Mørkholt, A S, Oklinski, M K, Larsen, A, Bockermann, R, Issazadeh-Navikas, S, Nieland, J G K, Kwon, T-H, Corthals, A, Nielsen, S & Nieland, J D V 2020, ' Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents ', PLoS ONE, vol. 15, no. 6, pp. e0234493 . https://doi.org/10.1371/journal.pone.0234493
PLoS ONE
Mørkholt, A S, Oklinski, M K, Larsen, A, Bockermann, R, Issazadeh-Navikas, S, Nieland, J G K, Kwon, T-H, Corthals, A, Nielsen, S & Nieland, J D V 2020, ' Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents ', PLOS ONE, vol. 15, no. 6, e0234493 . https://doi.org/10.1371/journal.pone.0234493
PLoS ONE, Vol 15, Iss 6, p e0234493 (2020)
Mørkholt, A S, Oklinski, M K, Larsen, A, Bockermann, R, Issazadeh-Navikas, S, Nieland, J G K, Kwon, T H, Corthals, A, Nielsen, S & Nieland, J D V 2020, ' Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents ', PLOS ONE, vol. 15, no. 6, e0234493 . https://doi.org/10.1371/journal.pone.0234493
PLoS ONE
Mørkholt, A S, Oklinski, M K, Larsen, A, Bockermann, R, Issazadeh-Navikas, S, Nieland, J G K, Kwon, T-H, Corthals, A, Nielsen, S & Nieland, J D V 2020, ' Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents ', PLOS ONE, vol. 15, no. 6, e0234493 . https://doi.org/10.1371/journal.pone.0234493
PLoS ONE, Vol 15, Iss 6, p e0234493 (2020)
Mørkholt, A S, Oklinski, M K, Larsen, A, Bockermann, R, Issazadeh-Navikas, S, Nieland, J G K, Kwon, T H, Corthals, A, Nielsen, S & Nieland, J D V 2020, ' Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents ', PLOS ONE, vol. 15, no. 6, e0234493 . https://doi.org/10.1371/journal.pone.0234493
Multiple sclerosis (MS) is a neurodegenerative disease characterized by demyelination and inflammation. Dysregulated lipid metabolism and mitochondrial dysfunction are hypothesized to play a key role in MS. Carnitine Palmitoyl Transferase 1 (CPT1) is
Autor:
Thiago Berti Kirsten, Maria Martha Bernardi, Luciano Freitas Felício, Renato Corrêa Viana Casarin
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197060 (2018)
PLoS ONE
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Autism is characterized by social deficits, communication abnormalities, and repetitive behaviors. The risk factors appear to include genetic and environmental conditions, such as prenatal infections and maternal dietary factors. Previous investigati
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203837 (2018)
PLoS ONE
PLoS ONE
Countless neurodegenerative diseases are associated with perverse multiple targets of cyclic nucleotide signalling, hastening neuronal death. Cilostazol, a phosphodiesterase-III inhibitor, exerts neuroprotective effects against sundry models of neuro
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 3, p e0172784 (2017)
PLoS ONE, Vol 12, Iss 3, p e0172784 (2017)
Blood brain barrier (BBB) disruption is a key mechanism of subarachnoid hemorrhage (SAH)-induced brain injury. This study examined the mechanism of iron-induced BBB disruption after SAH and investigated the potential therapeutic effect of iron chelat
Autor:
Jennifer C. Arnold, Mark A. Cantu, Nicoleta L. Bugnariu, Ella A. Kasanga, Evan V. Papa, Michael F. Salvatore, Vicki A. Nejtek
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188538 (2017)
PLoS ONE
PLoS ONE
Identifying lifestyle strategies and allied neurobiological mechanisms that reduce aging-related motor impairment is imperative, given the accelerating number of retirees and increased life expectancy. A physically active lifestyle prior to old age c
Autor:
Laura R. Hinds, Lauren E. Chun, Matthew J. Hartsock, Robert L. Spencer, Elizabeth R. Woodruff, Jennifer A. Christensen
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175075 (2017)
PLoS ONE
PLoS ONE
Recent studies support plasticity in adult brain white matter structure and myelination in response to various experiential factors. One possible contributor to this plasticity may be activity-dependent modulation of serum- and glucocorticoid-inducib
Autor:
Mandar Deshpande, Xiao Ping Yang, Suresh S. Palaniyandi, Rajarajan Amirthalingam Thandavarayan, Guodong Pan, Vishal R. Mali, Jiang Xu
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163158 (2016)
PLoS ONE
PLoS ONE
Aldehyde dehydrogenase (ALDH) 2 is a mitochondrial isozyme of the heart involved in the metabolism of toxic aldehydes produced from oxidative stress. We hypothesized that hyperglycemia-mediated decrease in ALDH2 activity may impair mitochondrial resp
Autor:
Wei Lu, Zhuang-Li Hu, Shi-Ying Yuan, Jue Liu, Li-Hong Long, Jian-Guo Chen, Hai-Yun Zhou, Lan Ni, Jun Zhou, Yi Wang, Fang Wang
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0159513 (2016)
PLoS ONE
PLoS ONE
Chronic stress induces altered energy metabolism and plays important roles in the etiology of depression, in which the glucocorticoid negative feedback is disrupted due to imbalanced glucocorticoid receptor (GR) functions. The mechanism underlying th
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0182895 (2017)
PLoS ONE, Vol 12, Iss 8, p e0182895 (2017)
Impaired protein clearance likely increases the risk of protein accumulation disorders including Alzheimer's disease (AD). Protein degradation through the proteasome pathway decreases with age and in AD brains, and the Aβ42 peptide has been shown to