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Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198808 (2018)
To assess the effects of a topical anaesthetic (TA) and buccal meloxicam (BM) on behaviour, maximum wound temperature and wound morphology following amputation dehorning of beef calves, 50 unweaned Hereford calves were randomly allocated to: (1) sham
Autor:
Klaus Hoeffler, Judith Rohde, Peter Braubach, Anatol Ciubotaru, Axel Haverich, Doris Hoeltig, Norman Zinne, Marcus Krueger, Taufiek Konrad Rajab, Erin C. Boyle, Christian Biancosino, Burkhard Tuemmler, Karl-Heinz Waldmann
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193168 (2018)
PLoS ONE
PLoS ONE
The emergence of multi-drug resistant bacteria threatens to end the era of antibiotics. Drug resistant bacteria have evolved mechanisms to overcome antibiotics at therapeutic doses and further dose increases are not possible due to systemic toxicity.
Autor:
Tatsuo Nakamura, Yoshiki Shionoya, Katsuhisa Sunada, Keiji Shigeno, Michitaka Honda, Akira Nakada
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189297 (2017)
PLoS ONE
PLoS ONE
This study aimed to determine whether nerve regeneration by means of an artificial nerve conduit is promoted by ethanol-induced cervical sympathetic ganglion block (CSGB) in a canine model. This study involved two experiments-in part I, the authors e
Autor:
Laura A. Cagle, Lisa M. Franzi, Angela L. Linderholm, Jerold A. Last, Jason Y. Adams, Richart W. Harper, Nicholas J. Kenyon
Publikováno v:
PloS one, vol 12, iss 11
PLoS ONE
Cagle, LA; Franzi, LM; Linderholm, AL; Last, JA; Adams, JY; Harper, RW; et al.(2017). Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model. PLoS ONE, 12(11). doi: 10.1371/journal.pone.0187419. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9448m1d8
PLoS ONE, Vol 12, Iss 11, p e0187419 (2017)
PLoS ONE
Cagle, LA; Franzi, LM; Linderholm, AL; Last, JA; Adams, JY; Harper, RW; et al.(2017). Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model. PLoS ONE, 12(11). doi: 10.1371/journal.pone.0187419. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9448m1d8
PLoS ONE, Vol 12, Iss 11, p e0187419 (2017)
Background Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to red
Autor:
Alain Bel, Virginie Le Rolle, Jean-Luc Bonnet, Alfredo Hernandez, H. M. Romero-Ugalde, Philippe Mabo, Christine Henry, Guy Carrault
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2017, 12 (10), pp.e0186068. 〈10.1371/journal.pone.0186068〉
PLoS ONE, 2017, 12 (10), pp.e0186068. ⟨10.1371/journal.pone.0186068⟩
PLoS ONE, Public Library of Science, 2017, 12 (10), pp.e0186068. ⟨10.1371/journal.pone.0186068⟩
PLoS ONE, Vol 12, Iss 10, p e0186068 (2017)
PLoS ONE, Public Library of Science, 2017, 12 (10), pp.e0186068. 〈10.1371/journal.pone.0186068〉
PLoS ONE, 2017, 12 (10), pp.e0186068. ⟨10.1371/journal.pone.0186068⟩
PLoS ONE, Public Library of Science, 2017, 12 (10), pp.e0186068. ⟨10.1371/journal.pone.0186068⟩
PLoS ONE, Vol 12, Iss 10, p e0186068 (2017)
International audience; Vagus nerve stimulation (VNS) is an established adjunctive therapy for pharmacologically refractory epilepsy and depression and is currently in active clinical research for other applications. In current clinical studies, VNS
Autor:
Chiu Yen Chung, Ren Shyang Guo, Navneet Kumar Dubey, Chin-Fu Chen, Meng Huang Wu, Wei Bin Hsu, Ming Hung Shih, Kuo Ti Peng, Wen-Fu Lee, Tsung-Jen Huang, Meng Yow Hsieh, Chung-Sheng Shi, Tsai Yu Lin, Chang Jhih Cai, Chung Hang Wong
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 10, p e0186784 (2017)
PLoS ONE, Vol 12, Iss 10, p e0186784 (2017)
This study evaluates the sustained analgesic effect of ketorolac-eluting thermosensitive biodegradable hydrogel in the plantar incisional pain model of the rat hind-paw. A ketorolac-embedded 2, 2'-Bis (2-oxazolin) (BOX) linking methoxy-poly(ethylene
Autor:
Lise Vlerick, Nick Van Laeken, Chris Baeken, Ingeborgh Polis, Kathelijne Peremans, Filip De Vos, Robrecht Dockx, Jimmy Saunders
Publikováno v:
PLoS ONE
PLOS ONE
PLoS ONE, Vol 12, Iss 9, p e0185362 (2017)
PLOS ONE
PLoS ONE, Vol 12, Iss 9, p e0185362 (2017)
Background Currently, the rat has been a useful animal model in brain stimulation research. Nevertheless, extrapolating results from rodent repetitive Transcranial Magnetic Stimulation (rTMS) research to humans contains several hurdles. This suggests
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 9, p e0184911 (2017)
PLoS ONE, Vol 12, Iss 9, p e0184911 (2017)
Anesthesia for mice is commonly performed through the injection of parenteral agents via the intraperitoneal (IP) route. Variability in anesthetic sensitivities has been noted in mice resulting in inconsistencies in anesthetic depth and/or mortality.
Autor:
Megan O'Reilly, Po-Yin Cheung, Joseph LaBossiere, Georg M. Schmölzer, Tze-Fun Lee, Shaun Cowan, David L. Bigam, Elliott S Li
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 1, p e0146524 (2016)
PLoS ONE, Vol 11, Iss 1, p e0146524 (2016)
BACKGROUND:End-tidal CO2 (ETCO2), partial pressure of exhaled CO2 (PECO2), and volume of expired CO2 (VCO2) can be continuously monitored non-invasively to reflect pulmonary ventilation and perfusion status. Although ETCO2 ≥14 mmHg has been shown t
Autor:
Kao-Ping Chang, Jwu-Lai Yeh, Su-Shin Lee, Sheng-Hua Wu, Hui-Min David Wang, Chung-Sheng Lai, Chee-Yin Chai, Shu-Hung Huang, Aij-Lie Kwan, Sin-Daw Lin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0137563 (2015)
PLoS ONE, Vol 10, Iss 9, p e0137563 (2015)
Burn-induced neuropathic pain is complex, and fat grafting has reportedly improved neuropathic pain. However, the mechanism of fat grafting in improving neuropathic pain is unclear. Previous investigations have found that neuroinflammation causes neu