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Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 1, p e0244244 (2021)
PLoS ONE, Vol 16, Iss 1, p e0244244 (2021)
Dietary interventions such as intermittent fasting and the ketogenic diet have demonstrated neuroprotective effects in various models of neurological insult. However, there has been a lack of evaluation of these interventions from a surgical perspect
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245553 (2021)
PLoS ONE
PLoS ONE
ObjectiveTo evaluate the effect of an intra-articular (IA) administration of triamcinolone hexacetonide, compared with saline.Patients and methodsForty (N = 40) hip joints were randomly assigned to a treatment group (THG, n = 20, receiving IA triamci
Autor:
Maria do Socorro de Sousa Cartágenes, José Osvaldo Barbosa Neto, João Batista Santos Garcia, Lyvia Maria Rodrigues de Sousa Gomes, Rayanne Luiza Tajra Mualem Araújo, Nicolau Gregori Czeczko
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245194 (2021)
PLoS ONE
PLoS ONE
Pharmacological treatment of osteoarthritis is still inadequate due to the low efficacy of the drugs used. Dexmedetomidine via the intra-articular (i.a.) route might be an option for the treatment of osteoarthritis-associated pain. The present study
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255155 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 8 (2021)
Use of normothermic ex vivo lung perfusion (EVLP) was adopted in clinical practice to assess the quality of marginal donor lungs. Subnormothermic perfusion temperatures are in use among other solid organs to improve biochemical, clinical and immunolo
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231090 (2020)
PLoS ONE
PLoS ONE
Sevoflurane and isoflurane are among the most commonly used general anesthetics for children including infants, but their impact on metabolism, especially on blood glucose level, in children is not well understood. We investigated the impacts of anes
Autor:
Sherreen G. Batts, Lee‐Ann M Murata, Thornton S. Mu, Aaron J. Clark, Catherine F. T. Uyehara, Amy M. Becker
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 10, p e0223604 (2019)
PLoS ONE, Vol 14, Iss 10, p e0223604 (2019)
IntroductionWhile extracorporeal membrane oxygenation (ECMO) is effective in preventing further hypoxemia and maintains blood flow in endotoxin-induced shock, ECMO alone does not reverse the hypotension. In this study, we tested whether concurrent va
Evaluation of the effects of differences in silicone hardness on rat model of lumbar spinal stenosis
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251464 (2021)
PLoS ONE, Vol 16, Iss 5, p e0251464 (2021)
Lumbar spinal stenosis (LSS), one of the most commonly reported spinal disorders, can cause loss of sensation and dyskinesia. In currently used animal models of LSS, the spinal cord is covered entirely with a silicone sheet, or block-shaped silicone
Autor:
M. Maas, Reinout A. Bem, Gustavo Matute-Bello, Jenny Juschten, Nicole P. Juffermans, Job B. M. van Woensel, Sarah A. Ingelse
Publikováno v:
PLoS ONE
PLoS ONE, 14(1):e0210172. Public Library of Science
Ingelse, S A, Juschten, J, Maas, M A W, Matute-Bello, G, Juffermans, N P, van Woensel, J B M & Bem, R A 2019, ' Fluid restriction reduces pulmonary edema in a model of acute lung injury in mechanically ventilated rats ', PLoS ONE, vol. 14, no. 1, e0210172 . https://doi.org/10.1371/journal.pone.0210172
PLoS ONE, Vol 14, Iss 1, p e0210172 (2019)
PLoS ONE, 14(1):e0210172. Public Library of Science
Ingelse, S A, Juschten, J, Maas, M A W, Matute-Bello, G, Juffermans, N P, van Woensel, J B M & Bem, R A 2019, ' Fluid restriction reduces pulmonary edema in a model of acute lung injury in mechanically ventilated rats ', PLoS ONE, vol. 14, no. 1, e0210172 . https://doi.org/10.1371/journal.pone.0210172
PLoS ONE, Vol 14, Iss 1, p e0210172 (2019)
Experimental acute lung injury models are often used to increase our knowledge on the acute respiratory distress syndrome (ARDS), however, existing animal models often do not take into account the impact of specific fluid strategies on the developmen
Autor:
Leonie Dreher, Hermann Reichenspurner, Helga Vitzhum, Jack Martin, Marisa Jelinek, D. Biermann, Heimo Ehmke, Alexander P. Schwoerer, S. Westhofen
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214513 (2019)
BackgroundUnloading of failing hearts by left ventricular assist devices induces an extensive cardiac remodeling which may lead to a reversal of the initial phenotype-or to its deterioration. The mechanisms underlying these processes are unclear.Hypo
Autor:
David L. Bigam, A. M. James Shapiro, Jordan J. Nostedt, Aducio Thiesen, Jessica Hopkins, Sunita Ghosh, Tom Churchill, Benjamin Adam, Darren H. Freed, Mackenzie C. Lees
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220786 (2019)
PLoS ONE
PLoS ONE
BackgroundNormothermic machine perfusion (NMP) of liver grafts donated after circulatory death (DCD) has shown promise in large animal and clinical trials. Following procurement, initial flush with a cold preservation solution is the standard of care