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Autor:
Banchob Sripa, Piti Ungarreevittaya, Chadamas Sakonsinsiri, Raynoo Thanan, Chawalit Pairojkul, Prakasit Sa Ngiamwibool, Sitthichai Iamsaard, Pirawan Poosekeaw
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0259075 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0259075 (2021)
Cholangiocarcinoma (CCA) is a group of heterogenous malignancies arising from bile duct epithelium with distinct pathological features. Adaptor proteins have implicated in cell proliferation, migration, and invasion of different cancer cells. The obj
Autor:
Michael F. Press, Dennis J. Slamon, Joan S. Brugge, Sara A. Hurvitz, Jason J. Zoeller, Judy Dering, Laura M. Selfors
Publikováno v:
PLoS ONE
PloS one, vol 16, iss 5
PLoS ONE, Vol 16, Iss 5, p e0251163 (2021)
PloS one, vol 16, iss 5
PLoS ONE, Vol 16, Iss 5, p e0251163 (2021)
Our previous pre-clinical work defined BCL-2 induction as a critical component of the adaptive response to lapatinib-mediated inhibition of HER2. To determine whether a similar BCL-2 upregulation occurs in lapatinib-treated patients, we evaluated gen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254853 (2021)
PLoS ONE, Vol 16, Iss 7, p e0254853 (2021)
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the western world. In previous studies, various proportion of patients was found to carry CD11b+ or CD11c+ B cells whose presence was an unfavourable prognostic factor. The exact mec
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0250109 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250109 (2021)
Idiopathic pulmonary fibrosis (IPF) and lung cancer share common risk factors, epigenetic and genetic alterations, the activation of similar signaling pathways and poor survival. The aim of this study was to examine the gene expression profiles of st
Autor:
Martin J. Hoogduijn, Elena G Arias-Salgado, Ana Merino, Sander S. Korevaar, Ana Montes-Worboys, Maria Molina-Molina, Carla C. Baan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0248415 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE, 16(3 March):e0248415. Public Library of Science
PLoS ONE, Vol 16, Iss 3, p e0248415 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE, 16(3 March):e0248415. Public Library of Science
© 2021 Merino et al.
[Background]: Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with limited treatment options in which the telomere shortening is a strong predictive factor of poor prognosis. Mesenchymal stromal cells (MSC
[Background]: Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with limited treatment options in which the telomere shortening is a strong predictive factor of poor prognosis. Mesenchymal stromal cells (MSC
Autor:
Douglas V. N. P. Oliveira, Guy Wayne Novotny, Claus Høgdall, Estrid Høgdall, Joanna Lopacinska-Jørgensen
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0255142 (2021)
Lopacinska-Jørgensen, J, Oliveira, D V N P, Novotny, G W, Høgdall, C K & Høgdall, E V 2021, ' Integrated microRNA and mRNA signatures associated with overall survival in epithelial ovarian cancer ', Plos One, vol. 16, no. 7 July, e0255142, pp. 1-15 . https://doi.org/10.1371/journal.pone.0255142
PLoS ONE
Lopacinska-Jørgensen, J, Oliveira, D V N P, Novotny, G W, Høgdall, C K & Høgdall, E V 2021, ' Integrated microRNA and mRNA signatures associated with overall survival in epithelial ovarian cancer ', Plos One, vol. 16, no. 7 July, e0255142, pp. 1-15 . https://doi.org/10.1371/journal.pone.0255142
PLoS ONE
Ovarian cancer (OC), the eighth-leading cause of cancer-related death among females worldwide, is mainly represented by epithelial OC (EOC) that can be further subdivided into four subtypes: serous (75%), endometrioid (10%), clear cell (10%), and muc
Autor:
Shu Ching Yang, Nan Haw Chow, Hung Wen Tsai, Yi Lin Chen, Wan Li Chen, Yi Chia Cheng, Ming Ching Lin, Chung Liang Ho, Wu Chou Su, Chien Chung Lin
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257152 (2021)
PLoS ONE
PLoS ONE
Approximately 5–7% of non–small cell lung cancer (NSCLC) cases harbor an anaplastic lymphoma kinase (ALK) fusion gene and may benefit from ALK inhibitor therapy. To detect ALK fusion genes, we developed a novel test using reverse transcription po
Autor:
Ashok Prabhu, Judith Huettemeister, Leif-Hendrik Boldt, Sandra C. Klaucke, Frank R. Heinzel, Philipp Lacour, Florian Blaschke, Abdul Shokor Parwani, Lars Bullinger, Sanzio Dimai, Harald Stachelscheid, Felix Hohendanner, Jan Kruse, Burkert Pieske, Lukas Semmler
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255976 (2021)
PLoS ONE
PLoS ONE
Background Cardiac injury associated with cytokine release frequently occurs in SARS-CoV-2 mediated coronavirus disease (COVID19) and mortality is particularly high in these patients. The mechanistic role of the COVID19 associated cytokine-storm for
Autor:
Kyoung Min Moon, Mi Jung Kwon, Young Wha Koh, Il Hwan Oh, Intazur Rahaman, Eun Kyung Kim, Kyueng-Whan Min, So Myoung Kim, So Won Kim, Byoung Kwan Son, Dong-Hoon Kim
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0245075 (2021)
PLoS ONE
PLoS ONE
High expression of glucose transporter family members, which augment glucose uptake and glycolytic flux, has been shown to play a pivotal role in the proliferation and survival of tumor cells, contributing to the energy supply, biosynthesis and homeo
Autor:
Marat S. Pavlyukov, L. I. Patrushev, Mikhail I. Shakhparonov, Alina M. Gamisoniya, Ksenia Anufrieva, Ksenia V. Morozova, T. F. Kovalenko, Lyudmila A. Ozolinya, Mikhail Yu. Bobrov, Yulia E. Dobrokhotova
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 1, p e0243093 (2021)
PLoS ONE, Vol 16, Iss 1, p e0243093 (2021)
The processed pseudogene PTENP1 is involved in the regulation of the expression of the PTEN and acts as a tumor suppressor in many types of malignances. In our previous study we showed that PTENP1 methylation is present not only in tumor, but also in