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Autor:
Takeshi Nakajima, Emi Kubo, Hideyuki Takeshima, Takayoshi Kishino, Yukio Kuniyoshi, Hiroyasu Igaki, Naoko Hattori, Satoshi Yamashita, Hidetsugu Nakazato, Yuji Tachimori, Toshikazu Ushijima
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147372 (2016)
PLoS ONE
PLoS ONE
The SWI/SNF chromatin remodeling complex is frequently inactivated by somatic mutations of its various components in various types of cancers, and also by aberrant DNA methylation. However, its somatic mutations and aberrant methylation in esophageal
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168229 (2016)
PLoS ONE
PLoS ONE
Introduction MicroRNAs are essential regulators of gene expression at the post-transcriptional level. Their expression is altered in cancer tissues, and evaluation of these alterations is considered a promising tool used to diagnose and identify prog
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148223 (2016)
PLoS ONE
PLoS ONE
Objectives Multidrug resistance-related protein 1 (MRP1) overexpression is a well acknowledged predictor of poor response to chemotherapy, but MRP1 also correlated to better prognosis in some reports, especially for patients not pretreated with chemo
Autor:
Patrick Baum, Steven S. Pullen, Heike Zimdahl, Martin Gerl, Franziska Wiech, Claudia Eisele, Ramona Schmid, Denis Delic, Richard Urquhart
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150154 (2016)
PLoS ONE
PLoS ONE
MicroRNAs (miRNAs) are short non-coding RNA species which are important post-transcriptional regulators of gene expression and play an important role in the pathogenesis of diabetic nephropathy. miRNAs are present in urine in a remarkably stable form
Autor:
Wenlou Liu, Shoulin Wang, Chao Wang, Zhan Zhang, Ziyu Wu, Yun Wang, Huanqiang Wang, Wei Zhang, Hengsen Xu
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168351 (2016)
PLoS ONE
PLoS ONE
Derlin-1 is overexpressed in various types of solid tumors and has an important function in cancer progression. However, its expression pattern in and association with the clinicopathological characteristics of human bladder cancer remain unclear. In
Autor:
Benjamin A. Neely, Maciek Sasinowski, Laura A. Marlow, Thomas Kislinger, Yunee Kim, Dariya I. Malyarenko, Richard R. Drake, Christopher E. Wilkins, Julius O. Nyalwidhe, John A. Copland, Alexandr Ignatchenko, Heather Sasinowska
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154074 (2016)
PLoS ONE
PLoS ONE
Renal cell carcinoma comprises 2 to 3% of malignancies in adults with the most prevalent subtype being clear-cell RCC (ccRCC). This type of cancer is well characterized at the genomic and transcriptomic level and is associated with a loss of VHL that
Autor:
Ryne C. Ramaker, Deborah L. Della Manna, Dongquan Chen, Sara J. Cooper, Gurudatta Naik, Sunil Sudarshan, Shi Wei, Tiffiny Cooper, Amy Zhao, Arjun S. Guru, Eddy S. Yang, Brittany N. Lasseigne, Guru Sonpavde, Pooja Ghatalia, Richard M. Myers
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160924 (2016)
PLoS ONE
PLoS ONE
Kinases are therapeutically actionable targets. Kinase inhibitors targeting vascular endothelial growth factor receptors (VEGFR) and mammalian target of rapamycin (mTOR) improve outcomes in metastatic clear cell renal cell carcinoma (ccRCC), but are
Autor:
Agatha S. Rosa, Cristiane A. Villela-Nogueira, Arlete Fernandes, Natalia M. Araujo, Christian Niel, Oscar C. Araujo, Vera Lucia Pannain
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153796 (2016)
PLoS ONE
PLoS ONE
Hepatocellular carcinoma (HCC) is the second most common cause of cancer mortality worldwide. Most cases of HCC are associated with cirrhosis related to chronic hepatitis B virus or hepatitis C virus infections. Hypermethylation of promoter regions i
Autor:
Paul S. Meltzer, Marbin Pineda, Sean Davis, J. Keith Killian, Yaroslav Teper, Rebecca Sorber, Sandra Burkett, Abisola Abisoye-Ogunniyan, Holger Pflicke, Satyajit Ray, Joshua J. Waterfall, Matt R. McCord, Udo Rudloff
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149833 (2016)
PLoS ONE
PLoS ONE
The genetic profile of human pancreatic cancers harbors considerable heterogeneity, which suggests a possible explanation for the pronounced inefficacy of single therapies in this disease. This observation has led to a belief that custom therapies ba
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162502 (2016)
PLoS ONE
PLoS ONE
Objective Ezrin and p130Cas are structural proteins with an important role in signaling pathways and have been shown to promote cancer dissemination. We previously reported on overexpression of both ezrin and p130Cas in breast carcinoma effusions com