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Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0230622 (2020)
PLoS ONE, Vol 15, Iss 3, p e0230622 (2020)
Background Circulating tumor DNA (ctDNA) is cell-free DNA that is released into peripheral blood by tumor cells. ctDNA harbors somatic mutations and mutant ctDNA obtained from blood can be used as a biomarker in advanced non-small cell lung cancer (N
Autor:
J.M. Galbis, Javier Alcácer, José Javier Martín de Llano, María Oliver, Carmen Carda, Manuel de la Mata, María Sancho-Tello, Julian Carretero, Lara Milian, Carlos Camps
Publikováno v:
PLoS ONE
PLoS One
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-FISABIO. Repositorio Institucional de Producción Científica
instname
PLoS ONE, Vol 15, Iss 2, p e0228909 (2020)
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
PLoS One
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-FISABIO. Repositorio Institucional de Producción Científica
instname
PLoS ONE, Vol 15, Iss 2, p e0228909 (2020)
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
Background/Objective Patients with non-small cell lung cancer (NSCLC) develop resistance to antitumor agents by mechanisms that involve the epithelial-to-mesenchymal transition (EMT). This necessitates the development of new complementary drugs, e.g.
Autor:
Yusuke Tsuruda, Taro Tobo, Yosuke Kuroda, Shotaro Kuramitsu, Koshi Mimori, Shinya Kidogami, Qingjiang Hu, Masaki Mori, Shuhei Ito, Takaaki Masuda, Sho Nambara, Eiji Oki, Masami Ueda, Kuniaki Sato
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0241140 (2020)
PLoS ONE
PLoS ONE
BackgroundPeritoneal dissemination (PD) frequently occurs in gastric cancer (GC) and is incurable. In this study, we aimed to identify novel PD-associated genes and clarify their clinical and biological significance in GC.Materials and methodsWe iden
Autor:
Debu Tripathy, Naoto T. Ueno, Kumiko Kida, Darren W. Davis, Diane D. Liu, James M. Reuben, Carlos H. Barcenas, Takeo Fujii, Minjeong Park, Vicente Valero, Mariana Chavez-MacGregor, Fanny Le Du, Weiguo Wu
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229903 (2020)
PLoS ONE
PLoS ONE
BackgroundTumor cells with a mesenchymal phenotype and/or cancer stem-like cells (CSCs) are known to contribute to metastasis and drug resistance. Circulating tumor cells (CTCs) undergoing epithelial-mesenchymal transition (EMT) and CTCs reflecting a
Autor:
Yasuo Iwadate, Ryuya Yamanaka, Atsushi Kawaguchi, Azusa Hayano, Hiroaki Hondoh, Junya Fukai, Yasuo Takashima, Koji Kajiwara
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229577 (2020)
PLoS ONE
PLoS ONE
MicroRNAs (miRNAs) inhibit protein function by silencing the translation of target mRNAs. However, in primary central nervous system lymphoma (PCNSL), the expression and functions of miRNAs are inadequately known. Here, we examined the expression of
Autor:
Dong M. Shin, Jeanne Kowalski, Ashok Reddy Dinasarapu, Conor E. Steuer, Sandra Seby, Xu Wang, Mihir R. Patel, Nabil F. Saba, Zhuo Georgia Chen, Kelly R. Magliocca, Christopher C. Griffith, Mark W. El-Deiry, Michael E. Zwick, Zhaohui S. Qin, Bhakti Dwivedi
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238497 (2020)
PLoS ONE
PLoS ONE
Human papilloma virus (HPV) causes a subset of head and neck squamous cell carcinomas (HNSCC) of the oropharynx. We combined targeted DNA- and genome-wide RNA-sequencing to identify genetic variants and gene expression signatures respectively from pa
Autor:
Arindam Maitra, Bidyut Roy, Sandip Ghose, Shreya Das, Partha P. Majumder, Nidhan K. Biswas, Sila Datta, Richa Singh, Anjana Mazumdar
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233058 (2020)
PLoS ONE
PLoS ONE
It is hypothesized that same driver gene mutations should be present in both oral leukoplakia and cancer tissues. So, we attempted to find out mutations at one of the driver genes, CASP8, in cancer and adjacent leukoplakia tissues. Patients (n = 27),
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243509 (2020)
PLoS ONE
PLoS ONE
ObjectiveThe carcinogenesis role ofPARP1in lung cancer is still not clear. Analysis at allelic levels cannot fully explain the function ofPARP1on lung cancer. Our study aims to further explore the relation betweenPARP1haplotypes and lung cancer.Mater
Autor:
Gunhild Mari Mælandsmo, Marta Nyakas, Erin McFadden, Patrik Wernhoff, Kari Dolven Jacobsen, Karine Flem-Karlsen, I. N. Farstad, Vivi Ann Flørenes
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 1, p e0227187 (2020)
PLoS ONE, Vol 15, Iss 1, p e0227187 (2020)
Receptor tyrosine kinase AXL is a one-pass transmembrane protein upregulated in cancers and associated with lower survival and therapy resistance. AXL can be cleaved by the A Disintegrin and Metalloproteinases (ADAM)10 and ADAM17, yielding a soluble
Autor:
Christopher Dubay, Michael J. Gough, Pippa Newell, Joanna Pucliowska, Ephraim Tang, Carlo Bifulco, Marka R. Crittenden, Terry R. Medler, Brian D. Piening, Emilio Alonso, Zeljka Jutric, Kristina H. Young, Paul D. Hansen, Venkatesh Rajamanickam, Andrew J. Gunderson, Brady Bernard
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0238380 (2020)
PLoS ONE
PLoS ONE
Pancreatic adenocarcinoma is characterized by a complex tumor environment with a wide diversity of infiltrating stromal and immune cell types that impact the tumor response to conventional treatments. However, even in this poorly responsive tumor the