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Autor:
Christopher Georg Németh, Volker Gassling, Jörg Wiltfang, Ole Ammerpohl, Christoph Röcken, Reiner Siebert
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215055 (2019)
Head and neck squamous cell carcinoma (HNSCC) affects about 700.000 individuals per year worldwide with oral squamous cell carcinoma (OSCC) as a major subcategory. Despite a comprehensive treatment concept including surgery, radiation, and chemothera
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0206423 (2018)
PLoS ONE, Vol 13, Iss 11, p e0206423 (2018)
Hepatitis A virus cellular receptor 1 (HAVCR1), which is also known as T-cell immunoglobulin and mucin domain 1 (TIM-1) is a TIM gene family member. In this study, we aimed to characterize the expression profile of HAVCR1 in GC, its prognostic value
Autor:
Hualiang Xiao, Xiaoge Zhou, Fang Liu, Huilan Rao, Qing Liu, Shigeo Nakamura, Weihua Yin, Zhe Wang, Gang Chen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 8, p e0201546 (2018)
PLoS ONE, Vol 13, Iss 8, p e0201546 (2018)
Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (EBV+ DLBCL) is typically an aggressive tumor in elderly patients. However, in a subset of young patients, EBV+ DLBCL follows a relatively indolent clinical course and exhibits a good re
Autor:
Noriteru Doi, Kiyohiko Angata, Nobuyoshi Hiraoka, Kazuaki Shimada, Yoshinori Ino, Hisashi Narimatsu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0242851 (2020)
PLoS ONE, Vol 15, Iss 11, p e0242851 (2020)
Mucin-type O-glycans are involved in cancer initiation and progression, although details of their biological and clinicopathological roles remain unclear. The aim of this study was to investigate the clinicopathological significance of β1,3-N-acetyl
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0238862 (2020)
PLoS ONE, Vol 15, Iss 9, p e0238862 (2020)
A model that recapitulates development of acquired therapeutic resistance is needed to improve oncology drug development and patient outcomes. To achieve this end, we established methods for the preparation and growth of spheroids from primary human
Autor:
Takanori Sasaki, Kei Tsuchihashi, Kazushige Koike, Hiroyoshi Hiratsuka, Tadashi Hasegawa, Kazuhiro Ogi, Shota Shimizu, Akihiro Miyazaki, Koyo Nishiyama, Takashi Sasaya, Hironari Dehari, Tomoko Sonoda, Toshihiko Torigoe
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0237465 (2020)
PLoS ONE, Vol 15, Iss 8, p e0237465 (2020)
Background Tumor-infiltrating lymphocytes include tumor-reactive lymphocytes and regulatory T-cells. However, the prognostic value of tumor-infiltrating lymphocytes in oral squamous cell carcinoma (OSCC) remains unclear. Methods We used immunohistoch
Autor:
Jiyoon Jung, Hoiseon Jeong, Woo Ho Kim, Hwa Eun Oh, Yoonjin Kwak, Eung Seok Lee, Sang-Hoon Jeong, Jung Woo Choi, Young Sik Kim, Ju Han Lee
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0236811 (2020)
PLoS ONE
PLoS ONE
In this study, we aimed to investigate the molecular biomarkers that are pivotal for the development and progression of gastric cancer (GC). We analyzed clinical specimens using RNA sequencing to identify the target genes. We found that the expressio
Autor:
Tatsuo Hata, Hiroki Shima, Takanori Morikawa, Masahiro Iseki, Takeshi Naitoh, Tomoyoshi Tachibana, Masamichi Mizuma, Hiroki Hayashi, Michiaki Unno, Fuyuhiko Motoi, Kazuhiko Igarashi, Kei Nakagawa, Yukie Suzuki, Kei Kawaguchi, Mitsuhiro Shimura, Takashi Suzuki, Takeshi Aoki, Tatsuyuki Takadate
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235904 (2020)
PLoS ONE
PLoS ONE
Pancreatic ductal adenocarcinoma is one of the most aggressive types of cancer. Certain proteins in the tumor microenvironment have attracted considerable attention owing to their association with tumor invasion and metastasis. Here, we used proteomi
Autor:
Bradford S. Hoppe, Mark V. Mishra, Caitlin Eggleston, Winter M. Thayer, John F.P. Bridges, Ellen M. Janssen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0235616 (2020)
PLoS ONE, Vol 15, Iss 7, p e0235616 (2020)
Background The Extended Prostate Cancer Index Composite (EPIC) instrument is a commonly used patient reported outcome (PRO) tool in prostate cancer clinical trials. Summary scores for EPIC subscales are calculated by averaging patient scores for attr
Autor:
Ih-Jen Su, Woei Cherng Shyu, Han Chieh Wu, Tsai-Chung Li, Hung Wen Tsai, Ting Wang, John Wang, Long Bin Jeng, Chiao Fang Teng
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234773 (2020)
PLoS ONE
PLoS ONE
Hepatocellular carcinoma (HCC) is among the leading causes of cancer-related death worldwide. Patients with hepatitis B virus (HBV) pre-S mutants in liver tissues or blood have been regarded as a high-risk population for HCC development and recurrenc