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Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217521 (2019)
PLoS ONE
PLoS ONE
BackgroundPPM1D (Protein phosphatase magnesium-dependent 1δ) is known as a damage response regulator, a part of the p53 negative feedback loop. Truncating mutations of PPM1D, resulting in overexpression, are frequently found in the blood of patients
Autor:
You Jin Chun, Jae Woo Choi, Min Hee Hong, Dongmin Jung, Hyeonju Son, Eun Kyung Cho, Young Joo Min, Sang-We Kim, Keunchil Park, Sung Sook Lee, Sangwoo Kim, Hye Ryun Kim, Byoung Chul Cho, Korean Lung Cancer Consortium (KLCC)
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224379 (2019)
PLoS ONE
PLoS ONE
The treatment of Lung adenocarcinoma (LUAD) could benefit from the incorporation of precision medicine. This study was to identify cancer-related genetic alterations by next generation sequencing (NGS) in resected LUAD samples from Korean patients an
Autor:
Eugene K. Lee, Gaurav Kaushik, Benjamin L. Woolbright, Jeffrey M. Holzbeierlein, Jill Hamilton-Reeves, John A. Taylor, Erika Abbott, Paige Martin, Ryan Didde, Shrikant Anant, Weiya Liu, Karim Pirani
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218737 (2019)
PLoS ONE
PLoS ONE
PurposeBladder cancer is a "Warburg-like" tumor characterized by a reliance on aerobic glycolysis and expression of pyruvate kinase M2 (PKM2). PKM2 oscillates between an active tetramer and an inactive dimer. We aim to further characterize PKM2, in p
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226553 (2019)
PLoS ONE
PLoS ONE
Background Pulmonary vascular endothelium is the main metabolic site for Angiotensin I-Converting Enzyme (ACE)-mediated degradation of several biologically-active peptides (angiotensin I, bradykinin, hemo-regulatory peptide Ac-SDKP). Primary lung can
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0210263 (2019)
PLoS ONE
PloS one, 14 (3
PLoS ONE
PloS one, 14 (3
Cancer progression results from a complex interplay between tumor cells and the extracellular milieu. In breast carcinoma, the stromal microenvironment has been suggested to play a major role in promoting tumor growth, progression, and invasion. The
Autor:
Elena Manuela Teodorescu, Gunna Christiansen, Shona Pedersen, Thøger Nielsen, Henrik Gregersen, Søren Risom Kristensen
Publikováno v:
PLoS ONE
Nielsen, T, Kristensen, S R, Gregersen, H, Teodorescu, E M, Christiansen, G & Pedersen, S 2019, ' Extracellular vesicle-associated procoagulant phospholipid and tissue factor activity in multiple myeloma ', PLOS ONE, vol. 14, no. 1, e0210835 . https://doi.org/10.1371/journal.pone.0210835
Nielsen, T, Kristensen, S R, Gregersen, H, Teodorescu, E M, Christiansen, G & Pedersen, S 2019, ' Extracellular vesicle-associated procoagulant phospholipid and tissue factor activity in multiple myeloma ', PLOS ONE, vol. 14, no. 1, 0210835 . https://doi.org/10.1371/journal.pone.0210835
PLoS ONE, Vol 14, Iss 1, p e0210835 (2019)
Nielsen, T, Kristensen, S R, Gregersen, H, Teodorescu, E M, Christiansen, G & Pedersen, S 2019, ' Extracellular vesicle-associated procoagulant phospholipid and tissue factor activity in multiple myeloma ', PLOS ONE, vol. 14, no. 1, e0210835 . https://doi.org/10.1371/journal.pone.0210835
Nielsen, T, Kristensen, S R, Gregersen, H, Teodorescu, E M, Christiansen, G & Pedersen, S 2019, ' Extracellular vesicle-associated procoagulant phospholipid and tissue factor activity in multiple myeloma ', PLOS ONE, vol. 14, no. 1, 0210835 . https://doi.org/10.1371/journal.pone.0210835
PLoS ONE, Vol 14, Iss 1, p e0210835 (2019)
Multiple myeloma (MM) patients have increased risk of developing venous thromboembolism, but the underlying mechanisms and the effect on the coagulation system of the disease and the current cancer therapies are not known. It is possible that cancer-
Autor:
Kazunori Nakase, Naoyuki Katayama, Rino Arakawa, Kohshi Ohishi, Masahiro Masuya, Isao Tawara, Hiroshi Miwa, Yuki Kageyama
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 12, p e0209295 (2018)
PLoS ONE, Vol 13, Iss 12, p e0209295 (2018)
CD25 is expressed on leukemic cells in 10–20% cases of acute myeloid leukemia (AML), and its expression is associated with poor prognosis. We reevaluated the relationship between CD25 expression and the leukemia-initiating cell (LIC) properties of
Autor:
Ji Kon Ryu, Jin Won Kim, Jaihwan Kim, Yong-Tae Kim, Woo Hyun Paik, Jong-Chan Lee, Jin-Hyeok Hwang, Haeryoung Kim, Sang Hyub Lee
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 12, p e0209104 (2018)
PLoS ONE, Vol 13, Iss 12, p e0209104 (2018)
Gemcitabine is a principal chemotherapeutic agent for biliary tract cancer (BTC). Expression of human equilibrative nucleoside transporter 1 (hENT1) is regarded as a potential predictive biomarker for a gemcitabine response in some cancers. This stud
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 1, p e0210399 (2019)
PLoS ONE, Vol 14, Iss 1, p e0210399 (2019)
Angiogenesis is important for the progression of cutaneous melanoma. Here, we analyzed the prognostic impact of the angiogenic factor urokinase plasminogen activator resecptor (uPAR), vascular proliferation index (VPI) and tumor necrosis as a measure
Autor:
Ismini Lasithiotaki, Eliza Tsitoura, Katerina M. Antoniou, Nikolaos Tzanakis, Katerina D. Samara, Athina Trachalaki, Irini Charalambous
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 10, p e0205242 (2018)
PLoS ONE, Vol 13, Iss 10, p e0205242 (2018)
Lung cancer (LC) remains the leading cause of cancer-related mortality. The interaction of cancer cells with their microenvironment, results in tumor escape or elimination. Alveolar macrophages (AMs) play a significant role in lung immunoregulation,