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Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0250109 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250109 (2021)
Idiopathic pulmonary fibrosis (IPF) and lung cancer share common risk factors, epigenetic and genetic alterations, the activation of similar signaling pathways and poor survival. The aim of this study was to examine the gene expression profiles of st
Autor:
Douglas V. N. P. Oliveira, Guy Wayne Novotny, Claus Høgdall, Estrid Høgdall, Joanna Lopacinska-Jørgensen
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0255142 (2021)
Lopacinska-Jørgensen, J, Oliveira, D V N P, Novotny, G W, Høgdall, C K & Høgdall, E V 2021, ' Integrated microRNA and mRNA signatures associated with overall survival in epithelial ovarian cancer ', Plos One, vol. 16, no. 7 July, e0255142, pp. 1-15 . https://doi.org/10.1371/journal.pone.0255142
PLoS ONE
Lopacinska-Jørgensen, J, Oliveira, D V N P, Novotny, G W, Høgdall, C K & Høgdall, E V 2021, ' Integrated microRNA and mRNA signatures associated with overall survival in epithelial ovarian cancer ', Plos One, vol. 16, no. 7 July, e0255142, pp. 1-15 . https://doi.org/10.1371/journal.pone.0255142
PLoS ONE
Ovarian cancer (OC), the eighth-leading cause of cancer-related death among females worldwide, is mainly represented by epithelial OC (EOC) that can be further subdivided into four subtypes: serous (75%), endometrioid (10%), clear cell (10%), and muc
Autor:
Marat S. Pavlyukov, L. I. Patrushev, Mikhail I. Shakhparonov, Alina M. Gamisoniya, Ksenia Anufrieva, Ksenia V. Morozova, T. F. Kovalenko, Lyudmila A. Ozolinya, Mikhail Yu. Bobrov, Yulia E. Dobrokhotova
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 1, p e0243093 (2021)
PLoS ONE, Vol 16, Iss 1, p e0243093 (2021)
The processed pseudogene PTENP1 is involved in the regulation of the expression of the PTEN and acts as a tumor suppressor in many types of malignances. In our previous study we showed that PTENP1 methylation is present not only in tumor, but also in
Autor:
Piet Pattyn, Charlotte Vandeputte, Lieven Depypere, Bram De Laere, Philippe Nafteux, Katleen De Preter, Steffi Oeyen, Annouck Philippron
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251052 (2021)
PLOS ONE
PLoS ONE, Vol 16, Iss 5, p e0251052 (2021)
PLOS ONE
Objective The enrichment of circulating tumor cells (CTCs) from blood provides a minimally invasive method for biomarker discovery in cancer. Longitudinal interrogation allows monitoring or prediction of therapy response, detection of minimal residua
Autor:
Krisztina Schlachter, András Kiss, Gábor Lotz, Ildikó Illyés, Milán Csengeri, Gábor Lendvai, Katalin Borka, Zsuzsa Schaff, Tímea Szekerczés, Erzsébet Szabó
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0253065 (2021)
PLoS ONE
PLoS ONE
The presence of autophagy has been indicated in cholangiocarcinoma (CC), which disease has poor prognosis and limited treatment options. Recently, CC has been classified by anatomical localization as intrahepatic (iCC), perihilar (pCC) and distal (dC
Autor:
Clara Benna, Alessandra Comparato, Salvatore Pucciarelli, Andrea Errico, Isacco Maretto, Marina Bortolami, Fabio Farinati, Umberto Cillo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0244356 (2020)
PLoS ONE, Vol 15, Iss 12, p e0244356 (2020)
The physiological role of autophagy in the progression of liver diseases is still debated. To understand the clinical relevance of autophagy in primary e secondary hepatic tumors, we analyzed the expression of mTOR (mammalian target of rapamycin), a
Autor:
J Fris, Zhaolin Xu, Gordon Flowerdew, Wenda L. Greer, Paola Marcato, Mathieu Castonguay, Drew Bethune, Akram Alwithenani, Paola A. Marignani, Daniel French, Mary MacNeil, Wojciech Morzycki, Madelaine Plourde, Harry Henteleff, Stephanie Snow, Marika Forsythe, Arik Drucker
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251080 (2021)
PLoS ONE, Vol 16, Iss 5, p e0251080 (2021)
Most lung cancer patients are diagnosed at an advanced stage, limiting their treatment options with very low response rate. Lung cancer is the most common cause of cancer death worldwide. Therapies that target driver gene mutations (e.g. EGFR, ALK, R
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0247928 (2021)
PLoS ONE, Vol 16, Iss 3, p e0247928 (2021)
In this study, we identified long non-coding RNAs (lncRNAs) associated with DNA methylation in lung adenocarcinoma (LUAD) using clinical and methylation/expression data from 184 qualified LUAD tissue samples and 21 normal lung-tissue samples from The
Autor:
Kun-Tu Yeh, Himani Kumari, Jie-Ting Low, Yu-Ming Chuang, Yin-Chen Chen, Yu-Ting Lee, Shu-Hui Lin, Wan-Hong Huang, Hongchuan Jin, Mita T. M. T. Tran, Po-Yen Hsu, Michael W.Y. Chan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0250499 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250499 (2021)
Gastric cancer is one of the leading causes of cancer death worldwide. Previous studies demonstrated that activation of STAT3 is crucial for the development and progression of gastric cancer. However, the role of STAT3 in neuronal related gene methyl
Autor:
Akinobu Taketomi, Moto Fukai, Hideki Yokoo, Toshiya Kamiyama, Kanako C. Hatanaka, Takeshi Aiyama, Yutaka Hatanaka, Tatsuya Orimo, Takanori Ohata
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239462 (2020)
PLoS ONE, Vol 15, Iss 9, p e0239462 (2020)
This study was performed to determine the clinical significance of adenomatous polyposis coli (APC)-binding protein end-binding 1 (EB1) in hepatocellular carcinoma (HCC) and to characterize its biochemical role in comparison with previous reports. We