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Autor:
Banchob Sripa, Piti Ungarreevittaya, Chadamas Sakonsinsiri, Raynoo Thanan, Chawalit Pairojkul, Prakasit Sa Ngiamwibool, Sitthichai Iamsaard, Pirawan Poosekeaw
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0259075 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0259075 (2021)
Cholangiocarcinoma (CCA) is a group of heterogenous malignancies arising from bile duct epithelium with distinct pathological features. Adaptor proteins have implicated in cell proliferation, migration, and invasion of different cancer cells. The obj
Autor:
Michael F. Press, Dennis J. Slamon, Joan S. Brugge, Sara A. Hurvitz, Jason J. Zoeller, Judy Dering, Laura M. Selfors
Publikováno v:
PLoS ONE
PloS one, vol 16, iss 5
PLoS ONE, Vol 16, Iss 5, p e0251163 (2021)
PloS one, vol 16, iss 5
PLoS ONE, Vol 16, Iss 5, p e0251163 (2021)
Our previous pre-clinical work defined BCL-2 induction as a critical component of the adaptive response to lapatinib-mediated inhibition of HER2. To determine whether a similar BCL-2 upregulation occurs in lapatinib-treated patients, we evaluated gen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254853 (2021)
PLoS ONE, Vol 16, Iss 7, p e0254853 (2021)
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the western world. In previous studies, various proportion of patients was found to carry CD11b+ or CD11c+ B cells whose presence was an unfavourable prognostic factor. The exact mec
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0250109 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250109 (2021)
Idiopathic pulmonary fibrosis (IPF) and lung cancer share common risk factors, epigenetic and genetic alterations, the activation of similar signaling pathways and poor survival. The aim of this study was to examine the gene expression profiles of st
Autor:
Douglas V. N. P. Oliveira, Guy Wayne Novotny, Claus Høgdall, Estrid Høgdall, Joanna Lopacinska-Jørgensen
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0255142 (2021)
Lopacinska-Jørgensen, J, Oliveira, D V N P, Novotny, G W, Høgdall, C K & Høgdall, E V 2021, ' Integrated microRNA and mRNA signatures associated with overall survival in epithelial ovarian cancer ', Plos One, vol. 16, no. 7 July, e0255142, pp. 1-15 . https://doi.org/10.1371/journal.pone.0255142
PLoS ONE
Lopacinska-Jørgensen, J, Oliveira, D V N P, Novotny, G W, Høgdall, C K & Høgdall, E V 2021, ' Integrated microRNA and mRNA signatures associated with overall survival in epithelial ovarian cancer ', Plos One, vol. 16, no. 7 July, e0255142, pp. 1-15 . https://doi.org/10.1371/journal.pone.0255142
PLoS ONE
Ovarian cancer (OC), the eighth-leading cause of cancer-related death among females worldwide, is mainly represented by epithelial OC (EOC) that can be further subdivided into four subtypes: serous (75%), endometrioid (10%), clear cell (10%), and muc
Autor:
Shu Ching Yang, Nan Haw Chow, Hung Wen Tsai, Yi Lin Chen, Wan Li Chen, Yi Chia Cheng, Ming Ching Lin, Chung Liang Ho, Wu Chou Su, Chien Chung Lin
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257152 (2021)
PLoS ONE
PLoS ONE
Approximately 5–7% of non–small cell lung cancer (NSCLC) cases harbor an anaplastic lymphoma kinase (ALK) fusion gene and may benefit from ALK inhibitor therapy. To detect ALK fusion genes, we developed a novel test using reverse transcription po
Autor:
Kyoung Min Moon, Mi Jung Kwon, Young Wha Koh, Il Hwan Oh, Intazur Rahaman, Eun Kyung Kim, Kyueng-Whan Min, So Myoung Kim, So Won Kim, Byoung Kwan Son, Dong-Hoon Kim
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0245075 (2021)
PLoS ONE
PLoS ONE
High expression of glucose transporter family members, which augment glucose uptake and glycolytic flux, has been shown to play a pivotal role in the proliferation and survival of tumor cells, contributing to the energy supply, biosynthesis and homeo
Autor:
Marat S. Pavlyukov, L. I. Patrushev, Mikhail I. Shakhparonov, Alina M. Gamisoniya, Ksenia Anufrieva, Ksenia V. Morozova, T. F. Kovalenko, Lyudmila A. Ozolinya, Mikhail Yu. Bobrov, Yulia E. Dobrokhotova
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 1, p e0243093 (2021)
PLoS ONE, Vol 16, Iss 1, p e0243093 (2021)
The processed pseudogene PTENP1 is involved in the regulation of the expression of the PTEN and acts as a tumor suppressor in many types of malignances. In our previous study we showed that PTENP1 methylation is present not only in tumor, but also in
Autor:
Piet Pattyn, Charlotte Vandeputte, Lieven Depypere, Bram De Laere, Philippe Nafteux, Katleen De Preter, Steffi Oeyen, Annouck Philippron
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251052 (2021)
PLOS ONE
PLoS ONE, Vol 16, Iss 5, p e0251052 (2021)
PLOS ONE
Objective The enrichment of circulating tumor cells (CTCs) from blood provides a minimally invasive method for biomarker discovery in cancer. Longitudinal interrogation allows monitoring or prediction of therapy response, detection of minimal residua
Autor:
Anthony M. Magliocco, Robert M. Wenham, Susan M McCarthy, Sachin M. Apte, Jennifer B. Permuth, Dung-Tsa Chen, Ardeshir Hakam, Johnathan M. Lancaster, Douglas C. Marchion, Daryoush Saeed-Vafa, Alexis S. Lopez, Brett M. Reid
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0256615 (2021)
PLoS ONE
PLoS ONE
Loss of stromal caveolin-1 (Cav-1) is a biomarker of a cancer-associated fibroblast (CAF) phenotype and is related to progression, metastasis, and poor outcomes in several cancers. The objective of this study was to evaluate the clinical significance