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Autor:
Michael F. Press, Dennis J. Slamon, Joan S. Brugge, Sara A. Hurvitz, Jason J. Zoeller, Judy Dering, Laura M. Selfors
Publikováno v:
PLoS ONE
PloS one, vol 16, iss 5
PLoS ONE, Vol 16, Iss 5, p e0251163 (2021)
PloS one, vol 16, iss 5
PLoS ONE, Vol 16, Iss 5, p e0251163 (2021)
Our previous pre-clinical work defined BCL-2 induction as a critical component of the adaptive response to lapatinib-mediated inhibition of HER2. To determine whether a similar BCL-2 upregulation occurs in lapatinib-treated patients, we evaluated gen
Autor:
Kyoung Min Moon, Mi Jung Kwon, Young Wha Koh, Il Hwan Oh, Intazur Rahaman, Eun Kyung Kim, Kyueng-Whan Min, So Myoung Kim, So Won Kim, Byoung Kwan Son, Dong-Hoon Kim
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0245075 (2021)
PLoS ONE
PLoS ONE
High expression of glucose transporter family members, which augment glucose uptake and glycolytic flux, has been shown to play a pivotal role in the proliferation and survival of tumor cells, contributing to the energy supply, biosynthesis and homeo
Autor:
Piet Pattyn, Charlotte Vandeputte, Lieven Depypere, Bram De Laere, Philippe Nafteux, Katleen De Preter, Steffi Oeyen, Annouck Philippron
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251052 (2021)
PLOS ONE
PLoS ONE, Vol 16, Iss 5, p e0251052 (2021)
PLOS ONE
Objective The enrichment of circulating tumor cells (CTCs) from blood provides a minimally invasive method for biomarker discovery in cancer. Longitudinal interrogation allows monitoring or prediction of therapy response, detection of minimal residua
Autor:
Sang Hoon Ahn, Hye Seung Lee, Do Joong Park, Hyung Ho Kim, Ji Won Kim, Jin Won Kim, Kui Jin Kim, Keun Wook Lee, Jieun Kim, Jiwon Koh, Ji Hea Sung, Koung Jin Suh
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252480 (2021)
PLoS ONE
PLoS ONE
Peripheral regulatory T cells (pTregs) are a highly immunosuppressive fraction of CD4+ T cells. We aimed to evaluate the clinical significance of pTregs in patients with gastric cancer and to determine the correlation between pTregs and immune cell i
Autor:
Ahmed El-Damen, Martin Götte, Sherif Abdelaziz Ibrahim, Nancy Adriana Espinoza-Sánchez, Mohamed El-Shinawi, M. A. Badawy, Sarah Atef Fahim, Sarah Hamdy Ahmed, Burkhard Greve
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0250642 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250642 (2021)
Inflammatory breast cancer (IBC) is a rare, but aggressive entity of breast carcinoma with rapid dermal lymphatic invasion in young females. It is either poorly or misdiagnosed as mastitis because of the absence of a distinct lump. Small extracellula
Autor:
Kun-Tu Yeh, Himani Kumari, Jie-Ting Low, Yu-Ming Chuang, Yin-Chen Chen, Yu-Ting Lee, Shu-Hui Lin, Wan-Hong Huang, Hongchuan Jin, Mita T. M. T. Tran, Po-Yen Hsu, Michael W.Y. Chan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0250499 (2021)
PLoS ONE, Vol 16, Iss 4, p e0250499 (2021)
Gastric cancer is one of the leading causes of cancer death worldwide. Previous studies demonstrated that activation of STAT3 is crucial for the development and progression of gastric cancer. However, the role of STAT3 in neuronal related gene methyl
Autor:
Hidemi Ito, Yuta Umezu, Genta Nagae, Satoru Takahashi, Takayoshi Umeda, Keisuke Katsushima, Ichiro Takeuchi, Miho Suzuki, Hiroyuki Aburatani, Keitaro Matsuo, Yutaka Kondo, Keiko Shinjo, Kazuo Hara, Shoji Tajima, Yusuke Okuno, Yoshiteru Murofushi, Kenji Yamao
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0233782 (2020)
PLoS ONE, Vol 15, Iss 6, p e0233782 (2020)
Despite recent advances in clinical treatment, pancreatic cancer remains a highly lethal malignancy. In order to improve the survival rate of patients with pancreatic cancer, the development of non-invasive diagnostic methods using effective biomarke
Autor:
Yusuke Tsuruda, Taro Tobo, Yosuke Kuroda, Shotaro Kuramitsu, Koshi Mimori, Shinya Kidogami, Qingjiang Hu, Masaki Mori, Shuhei Ito, Takaaki Masuda, Sho Nambara, Eiji Oki, Masami Ueda, Kuniaki Sato
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0241140 (2020)
PLoS ONE
PLoS ONE
BackgroundPeritoneal dissemination (PD) frequently occurs in gastric cancer (GC) and is incurable. In this study, we aimed to identify novel PD-associated genes and clarify their clinical and biological significance in GC.Materials and methodsWe iden
Autor:
Debu Tripathy, Naoto T. Ueno, Kumiko Kida, Darren W. Davis, Diane D. Liu, James M. Reuben, Carlos H. Barcenas, Takeo Fujii, Minjeong Park, Vicente Valero, Mariana Chavez-MacGregor, Fanny Le Du, Weiguo Wu
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229903 (2020)
PLoS ONE
PLoS ONE
BackgroundTumor cells with a mesenchymal phenotype and/or cancer stem-like cells (CSCs) are known to contribute to metastasis and drug resistance. Circulating tumor cells (CTCs) undergoing epithelial-mesenchymal transition (EMT) and CTCs reflecting a
Autor:
Yasuo Iwadate, Ryuya Yamanaka, Atsushi Kawaguchi, Azusa Hayano, Hiroaki Hondoh, Junya Fukai, Yasuo Takashima, Koji Kajiwara
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229577 (2020)
PLoS ONE
PLoS ONE
MicroRNAs (miRNAs) inhibit protein function by silencing the translation of target mRNAs. However, in primary central nervous system lymphoma (PCNSL), the expression and functions of miRNAs are inadequately known. Here, we examined the expression of