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Autor:
Nadezda V. Volkova, Simone Bertolini, Anton Gartner, Peter J. Campbell, Moritz Gerstung, Bin Wang, Víctor González-Huici, Bettina Meier
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258269 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258269 (2021)
Ionizing radiation (IR) is widely used in cancer therapy and accidental or environmental exposure is a major concern. However, little is known about the genome-wide effects IR exerts on germ cells and the relative contribution of DNA repair pathways
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251172 (2021)
PLoS ONE, Vol 16, Iss 5, p e0251172 (2021)
Within the classical eye-blink conditioning, Purkinje cells within the cerebellum are known to suppress their tonic firing rates for a well defined time period in response to the conditional stimulus after training. The temporal profile of the drop i
Autor:
Janita P Hogan, Bradford E. Peercy
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0248974 (2021)
PLoS ONE, Vol 16, Iss 4, p e0248974 (2021)
Pancreatic β cells, responsible for secreting insulin into the bloodstream and maintaining glucose homeostasis, are organized in the islets of Langerhans as clusters of electrically coupled cells. Gap junctions, connecting neighboring cells, coordin
Autor:
Kostas Pantopoulos, Edouard Charlebois
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0253475 (2021)
PLoS ONE
PLoS ONE
Hepcidin is a peptide hormone that targets the iron exporter ferroportin, thereby limiting iron entry into the bloodstream. It is generated in hepatocytes mainly in response to increased body iron stores or inflammatory cues. Iron stimulates expressi
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0245589 (2021)
PLoS ONE
PLoS ONE
Neural spike sorting is prerequisite to deciphering useful information from electrophysiological data recorded from the brain, in vitro and/or in vivo. Significant advancements in nanotechnology and nanofabrication has enabled neuroscientists and eng
Autor:
Morag A. Lewis, Karen P. Steel, Navid Banafshe, Jing Chen, Neil J. Ingham, Julia L. Crunden, Clarisse Panganiban
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258158 (2021)
PLoS ONE
PloS ONE
PLoS ONE
PloS ONE
Age-related hearing loss in humans (presbycusis) typically involves impairment of high frequency sensitivity before becoming progressively more severe at lower frequencies. Pathologies initially affecting lower frequency regions of hearing are less c
Autor:
Janelle C. Arthur, Jeremy Wang, Rachel M. Bleich, Sandra Zarmer, Kenneth W. Simpson, Belgin Dogan, Shiying Zhang
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0259141 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)
Adherent-invasive Escherichia coli (AIEC) is a pathovar linked to inflammatory bowel diseases (IBD), especially Crohn’s disease, and colorectal cancer. AIEC are genetically diverse, and in the absence of a universal molecular signature, are defined
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257318 (2021)
PLoS ONE
PLoS ONE
α-helices are deformable secondary structural components regularly observed in protein folds. The overall flexibility of an α-helix can be resolved into constituent physical deformations such as bending in two orthogonal planes and twisting along t
Autor:
Caleb E. Finch, Constantinos Sioutas, Hans Baertsch, Kristina Shkirkova, Krista Lamorie-Foote, Qinghai Liu, Michelle Connor, Todd E. Morgan, William J. Mack
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0253766 (2021)
PLoS ONE, Vol 16, Iss 7, p e0253766 (2021)
Exposure to ambient air pollution has been associated with white matter damage and neurocognitive decline. However, the mechanisms of this injury are not well understood and remain largely uncharacterized in experimental models. Prior studies have sh
Autor:
Álvaro de Jesús Ruíz-Baltazar, Claudia L. Vargas-Requena, Ericka Berenice Herrera-Ríos, Simón Yobanny Reyes-López, Jesús Alberto Garibay-Alvarado
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0246256 (2021)
PLoS ONE, Vol 16, Iss 5, p e0246256 (2021)
Progress in the manufacture of scaffolds in tissue engineering lies in the successful combination of materials such as bioceramics having properties as porosity, biocompatibility, water retention, protein adsorption, mechanical strength and biominera